Synergistic Liposome Compositions for Targeted Therapeutic Delivery
Legal Citation
Summary of the Inventive Concept
The inventive concept integrates pH-sensitive liposomes with AI, IoT, blockchain, and other distinct technologies to create a more powerful system for targeted delivery of therapeutic molecules to diseased tissue.
Background and Problem Solved
The original patent disclosed pH-sensitive liposomes for delivering molecules to cells, but it had limitations in terms of targeted delivery and real-time monitoring. The new inventive concept addresses these limitations by combining the liposomes with AI-powered diagnostic modules, IoT-enabled biosensors, and blockchain-based tracking systems to achieve more efficient and personalized treatment outcomes.
Detailed Description of the Inventive Concept
The synergistic liposome compositions comprise pH-sensitive liposomes integrated with AI-powered diagnostic modules for identifying optimal treatment sites, IoT-enabled biosensors for real-time pH level detection, and blockchain-based tracking systems for monitoring delivery efficacy. The AI module analyzes patient data and identifies the most effective treatment sites, while the IoT biosensors transmit pH level data to a cloud-based analytics platform for real-time treatment optimization. The blockchain-based tracking system ensures the integrity and security of the delivery process. The compositions can be adapted for personalized cancer treatment, synergistic delivery of multiple therapeutic agents, and real-time monitoring of liposome-mediated delivery.
Novelty and Inventive Step
The new claims introduce the integration of AI, IoT, and blockchain technologies with pH-sensitive liposomes, which is a non-obvious and novel combination that significantly enhances the targeted delivery of therapeutic molecules. The inventive concept's synergistic approach provides a more efficient, personalized, and secure treatment outcome compared to the original patent.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept may include the use of different AI algorithms, IoT sensor types, or blockchain protocols. Variations of the composition may include the integration of additional technologies, such as microRNA-based targeting mechanisms or nanoparticle-based delivery systems.
Potential Commercial Applications and Market
The synergistic liposome compositions have significant commercial potential in the pharmaceutical and biotechnology industries, particularly in the areas of targeted cancer therapy, personalized medicine, and real-time treatment monitoring. The market for these compositions is expected to grow rapidly as the demand for more efficient and effective treatment outcomes increases.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/1271 |
| A | A61 | A61K9/127 |
| A | A61 | A61K31/20 |
| A | A61 | A61K31/337 |
| A | A61 | A61K31/704 |
| A | A61 | A61K31/711 |
| A | A61 | A61K31/713 |
| A | A61 | A61K31/7105 |
| A | A61 | A61K47/6911 |
| A | A61 | A61P35/00 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical drug delivery systems, specifically targeted liposomal drug delivery technologies with a focus on pH-sensitive targeting mechanisms for therapeutic interventions
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with expertise in pharmaceutical formulation, nanotechnology, and targeted drug delivery systems, holding advanced degrees in biomedical engineering, chemistry, or pharmaceutical sciences, with working knowledge of emerging technologies in medical diagnostics and delivery platforms
Obviousness Rationale
A person having ordinary skill in the art would recognize that integrating digital technologies with existing pH-sensitive liposomal delivery systems represents a predictable extension of known targeted drug delivery approaches. The combination of AI, IoT, and blockchain with established liposomal targeting mechanisms follows a logical progression of enhancing therapeutic precision and monitoring capabilities. The fundamental principles of pH-sensitive targeting remain consistent, with technological additions providing incremental improvements in tracking and optimization.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,509 |
|---|---|
| Title | Liposome compositions and methods of use thereof |
| Assignee(s) | Yale University, University of Rhode Island Board of Trustees |