Adaptive Liposome Compositions for Niche Environments
Legal Citation
Summary of the Inventive Concept
This inventive concept discloses specialized liposome compositions and methods tailored for specific, challenging operational environments, including high-security facilities, disaster relief settings, extreme weather conditions, high-altitude environments, and high-temperature environments.
Background and Problem Solved
The original patent disclosed liposome compositions and methods for delivering molecules to cells. However, these compositions may not be suitable for specific, demanding environments where unique challenges arise. This inventive concept addresses the limitations of the original patent by adapting the liposome compositions to operate effectively in niche environments.
Detailed Description of the Inventive Concept
The new inventive concept comprises pH-sensitive liposome compositions that selectively release cargo molecules in response to a low pH microenvironment. These compositions are designed to operate in high-security facilities, disaster relief settings, extreme weather conditions, high-altitude environments, and high-temperature environments. For example, the liposome composition for high-security facilities features a secure storage container to prevent unauthorized access. The composition for disaster relief settings includes a monitoring system to track treatment efficacy. The weather-resistant packaging material in the extreme weather conditions composition ensures the liposomes remain stable. The pressure-resistant container in the high-altitude environment composition maintains the liposomes' integrity. The cooling system in the high-temperature environment composition ensures the patient's safety.
Novelty and Inventive Step
The new claims introduce novel, non-obvious adaptations of the original liposome compositions to address the unique challenges of niche environments. The inventive step lies in the specific design elements and components added to the original composition to make it functional in these environments.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include liposome compositions designed for underwater environments, space exploration, or other extreme conditions. Variations could include different types of cargo molecules, such as proteins or nucleic acids, or alternative mechanisms for triggering cargo release.
Potential Commercial Applications and Market
The adaptive liposome compositions have significant commercial potential in industries such as biotechnology, pharmaceuticals, and healthcare. Target markets include government agencies, disaster relief organizations, and companies operating in extreme environments.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K9/1271 |
| A | A61 | A61K9/127 |
| A | A61 | A61K31/20 |
| A | A61 | A61K31/337 |
| A | A61 | A61K31/704 |
| A | A61 | A61K31/711 |
| A | A61 | A61K31/713 |
| A | A61 | A61K31/7105 |
| A | A61 | A61K47/6911 |
| A | A61 | A61P35/00 |
Original Patent Information
| Patent Number | US 11,857,509 |
|---|---|
| Title | Liposome compositions and methods of use thereof |
| Assignee(s) | Yale University, University of Rhode Island Board of Trustees |