Adaptive Liposome Compositions for Niche Environments

Publication ID: 24-11857509_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Adaptive Liposome Compositions for Niche Environments,” Published Technical Disclosure No. 24-11857509_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857509_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,509.

Summary of the Inventive Concept

This inventive concept discloses specialized liposome compositions and methods tailored for specific, challenging operational environments, including high-security facilities, disaster relief settings, extreme weather conditions, high-altitude environments, and high-temperature environments.

Background and Problem Solved

The original patent disclosed liposome compositions and methods for delivering molecules to cells. However, these compositions may not be suitable for specific, demanding environments where unique challenges arise. This inventive concept addresses the limitations of the original patent by adapting the liposome compositions to operate effectively in niche environments.

Detailed Description of the Inventive Concept

The new inventive concept comprises pH-sensitive liposome compositions that selectively release cargo molecules in response to a low pH microenvironment. These compositions are designed to operate in high-security facilities, disaster relief settings, extreme weather conditions, high-altitude environments, and high-temperature environments. For example, the liposome composition for high-security facilities features a secure storage container to prevent unauthorized access. The composition for disaster relief settings includes a monitoring system to track treatment efficacy. The weather-resistant packaging material in the extreme weather conditions composition ensures the liposomes remain stable. The pressure-resistant container in the high-altitude environment composition maintains the liposomes' integrity. The cooling system in the high-temperature environment composition ensures the patient's safety.

Novelty and Inventive Step

The new claims introduce novel, non-obvious adaptations of the original liposome compositions to address the unique challenges of niche environments. The inventive step lies in the specific design elements and components added to the original composition to make it functional in these environments.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include liposome compositions designed for underwater environments, space exploration, or other extreme conditions. Variations could include different types of cargo molecules, such as proteins or nucleic acids, or alternative mechanisms for triggering cargo release.

Potential Commercial Applications and Market

The adaptive liposome compositions have significant commercial potential in industries such as biotechnology, pharmaceuticals, and healthcare. Target markets include government agencies, disaster relief organizations, and companies operating in extreme environments.

CPC Classifications

SectionClassGroup
A A61 A61K9/1271
A A61 A61K9/127
A A61 A61K31/20
A A61 A61K31/337
A A61 A61K31/704
A A61 A61K31/711
A A61 A61K31/713
A A61 A61K31/7105
A A61 A61K47/6911
A A61 A61P35/00

Field of Art

Pharmaceutical drug delivery systems, specifically liposomal compositions for targeted molecular transport, with expertise in pH-sensitive targeting mechanisms and cellular delivery techniques

Person of Ordinary Skill (PHOSITA) Profile

A skilled researcher with advanced degrees in pharmaceutical sciences, biochemistry, or biomedical engineering, possessing knowledge of liposomal drug delivery, membrane interactions, and targeted therapeutic strategies

Obviousness Rationale

A person of ordinary skill would recognize that the PTD's variations represent predictable extensions of the source patent's core liposomal delivery technology by applying known environmental adaptation strategies to the existing pH-sensitive liposome platform. The fundamental mechanism of pH-triggered cargo release remains consistent, with the PTD merely introducing contextual packaging and monitoring modifications that would be routine design considerations for a skilled practitioner. These variations represent standard engineering problem-solving approaches to expanding a base technological platform into diverse operational contexts.

Obvious Combinations & Variations

Source Patent Element
pH-triggered liposome cargo delivery mechanism using pHLIP polypeptides
PTD Variation
Adding secure storage containers and environment-specific packaging for high-security and disaster relief applications
Obviousness Reasoning
Adapting packaging for specific environments is a predictable design choice that does not alter the fundamental molecular delivery mechanism
Source Patent Element
Selective cellular targeting based on microenvironment pH
PTD Variation
Incorporating patient monitoring systems to track treatment efficacy in disaster relief settings
Obviousness Reasoning
Adding diagnostic tracking is a known technique in medical delivery systems that represents an obvious enhancement to the base technology
Source Patent Element
Liposome composition capable of membrane fusion and endocytosis
PTD Variation
Developing pressure-resistant and temperature-adaptive containers for extreme environment deployment
Obviousness Reasoning
Modifying storage containers to maintain liposome integrity in challenging conditions is a standard engineering approach with predictable outcomes
Source Patent Element
Cargo-loaded pH-sensitive liposome delivery method
PTD Variation
Expanding cargo molecule types to include proteins and nucleic acids in alternative embodiments
Obviousness Reasoning
Exploring alternative molecular payloads is an obvious iterative development for a skilled researcher familiar with drug delivery platforms
Source Patent Element
Cell membrane and endosomal compartment targeting mechanism
PTD Variation
Proposing delivery strategies for underwater, space exploration, and other extreme environments
Obviousness Reasoning
Extending delivery technologies to novel environments represents a logical progression of the base technological concept using known adaptation strategies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857509 and the disclosed variations, a person of ordinary skill in the art would find the proposed liposomal delivery adaptations obvious and non-inventive. The PTD demonstrates that the claimed environmental modifications and contextual extensions represent predictable design choices that do not rise to the level of non-obvious innovation, thereby establishing prior art that would render similar claims obvious under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,509
TitleLiposome compositions and methods of use thereof
Assignee(s)Yale University, University of Rhode Island Board of Trustees