Adaptive Liposome Compositions for Niche Environments

Publication ID: 24-11857509_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Adaptive Liposome Compositions for Niche Environments,” Published Technical Disclosure No. 24-11857509_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857509_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,509.

Summary of the Inventive Concept

This inventive concept discloses specialized liposome compositions and methods tailored for specific, challenging operational environments, including high-security facilities, disaster relief settings, extreme weather conditions, high-altitude environments, and high-temperature environments.

Background and Problem Solved

The original patent disclosed liposome compositions and methods for delivering molecules to cells. However, these compositions may not be suitable for specific, demanding environments where unique challenges arise. This inventive concept addresses the limitations of the original patent by adapting the liposome compositions to operate effectively in niche environments.

Detailed Description of the Inventive Concept

The new inventive concept comprises pH-sensitive liposome compositions that selectively release cargo molecules in response to a low pH microenvironment. These compositions are designed to operate in high-security facilities, disaster relief settings, extreme weather conditions, high-altitude environments, and high-temperature environments. For example, the liposome composition for high-security facilities features a secure storage container to prevent unauthorized access. The composition for disaster relief settings includes a monitoring system to track treatment efficacy. The weather-resistant packaging material in the extreme weather conditions composition ensures the liposomes remain stable. The pressure-resistant container in the high-altitude environment composition maintains the liposomes' integrity. The cooling system in the high-temperature environment composition ensures the patient's safety.

Novelty and Inventive Step

The new claims introduce novel, non-obvious adaptations of the original liposome compositions to address the unique challenges of niche environments. The inventive step lies in the specific design elements and components added to the original composition to make it functional in these environments.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include liposome compositions designed for underwater environments, space exploration, or other extreme conditions. Variations could include different types of cargo molecules, such as proteins or nucleic acids, or alternative mechanisms for triggering cargo release.

Potential Commercial Applications and Market

The adaptive liposome compositions have significant commercial potential in industries such as biotechnology, pharmaceuticals, and healthcare. Target markets include government agencies, disaster relief organizations, and companies operating in extreme environments.

CPC Classifications

SectionClassGroup
A A61 A61K9/1271
A A61 A61K9/127
A A61 A61K31/20
A A61 A61K31/337
A A61 A61K31/704
A A61 A61K31/711
A A61 A61K31/713
A A61 A61K31/7105
A A61 A61K47/6911
A A61 A61P35/00

Original Patent Information

Patent NumberUS 11,857,509
TitleLiposome compositions and methods of use thereof
Assignee(s)Yale University, University of Rhode Island Board of Trustees