Personalized Congenital Diarrhea Disorder Management Systems

Publication ID: 24-11857510_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Congenital Diarrhea Disorder Management Systems,” Published Technical Disclosure No. 24-11857510_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857510_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,510.

Summary of the Inventive Concept

A next-generation approach to managing congenital diarrhea disorder, leveraging advanced technologies such as gene editing, personalized nutrition, and wearable devices to provide tailored treatment and prevention strategies.

Background and Problem Solved

The original patent, 'Methods and compositions for treating congenital diarrhea disorder,' demonstrated the efficacy of proanthocyanidin polymer compositions in treating diarrhea associated with congenital diarrhea disorder. However, this approach has limitations, including the need for parenteral nutrition and the lack of personalized treatment options. The new inventive concept addresses these limitations by introducing a suite of innovative solutions that integrate cutting-edge technologies to provide more effective and personalized management of congenital diarrhea disorder.

Detailed Description of the Inventive Concept

The new inventive concept encompasses a range of innovative solutions, including a system for personalized gut microbiome modulation, a method for predicting the likelihood of developing congenital diarrhea disorder, a wearable device for monitoring and managing the disorder, a personalized nutrition and supplementation plan, and a method for gene editing in stem cells to correct genetic mutations associated with the disorder. These solutions leverage advanced technologies such as probiotics, gene editing, and wearable devices to provide tailored treatment and prevention strategies. For example, the system for personalized gut microbiome modulation uses a probiotic composition tailored to the subject's specific gut microbiome profile, administered in a synergistic manner with a proanthocyanidin polymer composition to enhance efficacy. The wearable device for monitoring and managing congenital diarrhea disorder in infants tracks changes in stool consistency and frequency, providing valuable insights for healthcare providers.

Novelty and Inventive Step

The new claims introduce a paradigm shift in the management of congenital diarrhea disorder, moving from a one-size-fits-all approach to personalized, tailored solutions that integrate advanced technologies. The inventive concept's novelty lies in its ability to combine cutting-edge technologies to provide a comprehensive management system, addressing the limitations of the original patent and providing a more effective and sustainable approach to treating congenital diarrhea disorder.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of artificial intelligence and machine learning algorithms to analyze gut microbiome data and predict disease susceptibility, or the development of implantable devices for continuous monitoring and management of congenital diarrhea disorder. Variations could include the use of different types of probiotics or gene editing technologies, or the integration of additional sensors and data analytics modules into the wearable device.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the healthcare industry, particularly in the areas of pediatrics and gastroenterology. The market for congenital diarrhea disorder management solutions is expected to grow as the prevalence of the disorder increases, and the inventive concept's personalized and tailored approach is likely to appeal to healthcare providers and patients seeking more effective and sustainable treatment options.

CPC Classifications

SectionClassGroup
A A61 A61K31/353
A A61 A61K9/0095
A A61 A61K9/28
A A61 A61K9/48
A A61 A61P1/04
A A61 A61P1/12

Field of Art

Medical biotechnology focusing on gastrointestinal disorders, specifically congenital diarrheal disorders (CDD), with expertise in pharmaceutical compositions, personalized medicine, and therapeutic interventions for pediatric patients

Person of Ordinary Skill (PHOSITA) Profile

A medical researcher or biotechnologist with advanced degree (PhD/MD), specialized knowledge in pediatric gastroenterology, familiarity with genetic disorders, proanthocyanidin therapies, and emerging personalized medicine technologies

Obviousness Rationale

A PHOSITA would recognize that the published technical disclosure represents a natural progression of the source patent's core therapeutic approach, extending the proanthocyanidin polymer treatment for congenital diarrheal disorders through predictable technological advancements in personalized medicine, genetic analysis, and monitoring technologies

Obvious Combinations & Variations

Source Patent Element
Method of treating secretory diarrhea using proanthocyanidin polymer composition
PTD Variation
Personalized gut microbiome modulation system combining probiotics with proanthocyanidin polymer
Obviousness Reasoning
Combining known therapeutic agents with personalized microbiome analysis represents a predictable optimization of existing treatment strategies, using standard techniques in precision medicine
Source Patent Element
Treatment method for infant subjects with congenital diarrheal disorders
PTD Variation
Wearable device for monitoring stool consistency and disease progression
Obviousness Reasoning
Development of monitoring technologies for pediatric patients is a logical extension of existing treatment protocols, representing an obvious technological improvement using standard sensor and data analytics techniques
Source Patent Element
Treatment of secretory diarrhea associated with specific genetic conditions
PTD Variation
Gene editing method using CRISPR-Cas9 to correct genetic mutations
Obviousness Reasoning
Application of emerging gene editing technologies to address genetic root causes of disorders is a foreseeable progression in precision medical interventions, utilizing well-established molecular biology techniques
Source Patent Element
Proanthocyanidin polymer composition for treating diarrheal disorders
PTD Variation
Personalized nutrition and supplementation plan integrating targeted composition administration
Obviousness Reasoning
Tailoring nutritional interventions to specific patient profiles represents a predictable refinement of existing therapeutic approaches, using standard nutritional and pharmaceutical customization techniques
Source Patent Element
Method of treating infants with congenital diarrheal disorders
PTD Variation
Genetic marker and microbiome analysis for predicting disease susceptibility
Obviousness Reasoning
Developing predictive diagnostic approaches using genetic and microbiome data is a natural progression in personalized medical diagnostics, representing an obvious application of standard genomic and microbiological analysis techniques
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857510 and the published technical disclosure, a person having ordinary skill in the art would find the claimed variations obvious, as they represent predictable technological extensions utilizing standard techniques in personalized medicine, genetic analysis, and therapeutic intervention for congenital diarrheal disorders, thereby rendering subsequent claims obvious under 35 U.S.C. ยง 103

Original Patent Information

Patent NumberUS 11,857,510
TitleMethods and compositions for treating congenital diarrhea disorder
Assignee(s)NAPO PHARMACEUTICALS, INC.