Intelligent Pharmaceutical Systems for Personalized Medicine

Publication ID: 24-11857512_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Pharmaceutical Systems for Personalized Medicine,” Published Technical Disclosure No. 24-11857512_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857512_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,512.

Summary of the Inventive Concept

The present inventive concept integrates pharmaceutical compositions comprising venglustat with distinct technologies such as AI, IoT, blockchain, and machine learning to create a new, more powerful system for personalized medicine, enabling real-time monitoring, adaptive dosing, and secure data management.

Background and Problem Solved

The original patent disclosed pharmaceutical compositions comprising venglustat, but lacked the ability to adapt to individual patient needs, ensure data integrity, and provide real-time feedback. The new inventive concept addresses these limitations by combining venglustat with innovative technologies to create a more effective and efficient system.

Detailed Description of the Inventive Concept

The new inventive concept comprises a pharmaceutical composition comprising venglustat, in free base or pharmaceutically acceptable salt form, integrated with an AI-powered dosing controller, IoT-enabled devices, blockchain-based secure data storage, and machine learning algorithms. The AI-powered dosing controller adjusts dosing regimens based on patient-specific factors and real-time health data. The IoT-enabled devices track patient adherence and provide real-time feedback to healthcare providers. The blockchain-based secure data storage ensures data integrity and confidentiality for patient health records. The machine learning algorithm predicts optimal dosing regimens based on patient genomics and medical history.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious in its integration of venglustat with AI, IoT, blockchain, and machine learning technologies to create a personalized medicine system that adapts to individual patient needs, ensuring real-time monitoring, adaptive dosing, and secure data management.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of other AI algorithms, different IoT devices, or alternative blockchain platforms. Additionally, the inventive concept could be adapted for use with other pharmaceutical compositions or therapeutic agents.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of personalized medicine, precision health, and digital therapeutics. The target market includes pharmaceutical companies, healthcare providers, and patients seeking more effective and efficient treatment options.

CPC Classifications

SectionClassGroup
A A61 A61K31/439
A A61 A61K9/0053
A A61 A61K9/2009
A A61 A61K9/2013
A A61 A61K9/2018
A A61 A61K9/2095
A A61 A61K9/485
A A61 A61K9/4833
A A61 A61K9/4858
A A61 A61K9/4866

Field of Art

Pharmaceutical formulation and personalized medicine technologies, specifically focusing on drug delivery systems, patient monitoring, and adaptive pharmaceutical interventions

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in pharmaceutical sciences, biomedical engineering, or related fields, possessing expertise in drug formulation, digital health technologies, data analytics, and interdisciplinary medical technology integration

Obviousness Rationale

A PHOSITA would recognize that integrating digital monitoring and adaptive technologies with pharmaceutical compositions represents a predictable evolution of personalized medicine. The source patent's pharmaceutical composition of venglustat provides a foundational technology that naturally invites technological augmentation through digital health innovations. The proposed variations represent logical extensions of existing pharmaceutical and digital health paradigms, utilizing well-established technologies to enhance drug delivery and patient management.

Obvious Combinations & Variations

Source Patent Element
Pharmaceutical composition comprising venglustat in free base or salt form
PTD Variation
AI-powered dosing controller that adjusts dosing regimens based on patient-specific factors
Obviousness Reasoning
Personalized medicine approaches are well-known, and adapting dosing based on individual patient data represents a predictable application of existing digital health technologies
Source Patent Element
Oral pharmaceutical composition with specific manufacturing process
PTD Variation
IoT-enabled devices tracking patient adherence and providing real-time healthcare provider feedback
Obviousness Reasoning
Patient monitoring technologies are standard in modern medical practice, and integrating them with pharmaceutical delivery represents an obvious technological progression
Source Patent Element
Pharmaceutical composition with specific excipients and formulation
PTD Variation
Blockchain-based secure data storage ensuring patient health record confidentiality
Obviousness Reasoning
Data security and privacy technologies are standard in healthcare, and applying blockchain to medical record management is a known technique with predictable results
Source Patent Element
Venglustat pharmaceutical composition for therapeutic intervention
PTD Variation
Machine learning algorithm predicting optimal dosing regimens based on patient genomics and medical history
Obviousness Reasoning
Predictive analytics in personalized medicine are well-established, and applying machine learning to dosing optimization represents a standard technological approach
Source Patent Element
Pharmaceutical composition with specific manufacturing parameters
PTD Variation
Cloud-based analytics platform providing real-time insights on patient response and treatment efficacy
Obviousness Reasoning
Remote health monitoring and data analytics are standard technologies in modern medical practice, representing a predictable extension of existing pharmaceutical delivery systems
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857512 and the published technical disclosure, a person having ordinary skill in the art would find the proposed variations of integrating AI, IoT, blockchain, and machine learning technologies with pharmaceutical compositions to be obvious extensions of existing technological capabilities. The combination represents a predictable application of known digital health technologies to pharmaceutical delivery systems, rendering potential patent claims covering such integrations obvious and thus unpatentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,512
TitlePharmaceutical compositions comprising venglustat
Assignee(s)Genzyme Corporation