Neurotherapeutic Applications of Antiviral Compounds
Legal Citation
Summary of the Inventive Concept
The present inventive concept leverages the core technology of the original patent to develop novel therapeutic approaches for treating neurological disorders, neuroinflammation, neurodegenerative diseases, and anxiety disorders, thereby expanding the scope of the original invention.
Background and Problem Solved
The original patent disclosed compounds and compositions useful for treating coronavirus-associated diseases. However, the patent did not explore the potential of these compounds in addressing neurological disorders. The present inventive concept addresses this limitation by applying the core technology to develop novel therapeutic approaches for neurological disorders, thereby providing a new avenue for treatment.
Detailed Description of the Inventive Concept
The inventive concept involves the use of compounds represented by Formula I, which exhibit antiviral and/or anti-inflammatory effects on neurological cells. These compounds can be administered via various routes, including nasal sprays, to prevent neuroinflammation and treat neurodegenerative diseases. The compounds can also be formulated with neuroprotective agents to enhance their therapeutic efficacy. Furthermore, the inventive concept encompasses the use of nanoparticle formulations and transcranial magnetic stimulation devices to deliver the compounds to the brain, thereby enhancing their bioavailability and therapeutic effect.
Novelty and Inventive Step
The present inventive concept is novel and non-obvious over the original patent because it applies the core technology to an entirely new field of neurological disorders, which was not contemplated in the original patent. The inventive concept involves the identification of new therapeutic applications, new routes of administration, and new formulations, which are not obvious from the original patent.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept may involve the use of different compounds, different routes of administration, or different formulations. For example, the compounds may be administered orally or intravenously, or they may be formulated with other neuroprotective agents or anti-inflammatory compounds. Additionally, the inventive concept may be adapted for use in treating other neurological disorders, such as Parkinson's disease or Alzheimer's disease.
Potential Commercial Applications and Market
The present inventive concept has significant commercial potential in the field of neurological disorders, which is a large and growing market. The inventive concept may be developed into novel therapeutic products, such as nasal sprays or nanoparticle formulations, which could be marketed to pharmaceutical companies or healthcare providers. The market potential is substantial, given the high incidence and prevalence of neurological disorders, and the lack of effective treatments for these disorders.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K31/122 |
| A | A61 | A61K9/0053 |
| A | A61 | A61K9/0095 |
| A | A61 | A61K9/127 |
| A | A61 | A61K9/2009 |
| A | A61 | A61K9/2013 |
| A | A61 | A61K9/2018 |
| A | A61 | A61K9/2054 |
| A | A61 | A61K9/2095 |
| A | A61 | A61K9/282 |
| A | A61 | A61K9/2833 |
| A | A61 | A61K9/4833 |
| A | A61 | A61K9/4858 |
| A | A61 | A61K9/4866 |
| A | A61 | A61K31/198 |
| A | A61 | A61K31/222 |
| A | A61 | A61K31/381 |
| A | A61 | A61K31/40 |
| A | A61 | A61K31/422 |
| A | A61 | A61K31/433 |
| A | A61 | A61K31/454 |
| A | A61 | A61K31/513 |
| A | A61 | A61K31/536 |
| A | A61 | A61K36/30 |
| A | A61 | A61P31/14 |
| A | A61 | A61K2236/51 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical chemistry and drug delivery systems, specifically focused on antiviral compounds and neurological therapeutic interventions, with expertise in molecular formulation, drug targeting, and neurological disease treatment
Person of Ordinary Skill (PHOSITA) Profile
A researcher with advanced degrees in pharmaceutical sciences or medicinal chemistry, possessing knowledge of drug repurposing, neurological disease mechanisms, and advanced drug delivery technologies
Obviousness Rationale
A PHOSITA would recognize the natural extension of the source patent's antiviral compounds into neurological applications based on the known anti-inflammatory and cellular protective properties of the original compounds. The disclosed neurotherapeutic variations represent predictable applications of the core molecular technology, utilizing standard pharmaceutical engineering techniques for expanding therapeutic uses. The PTD demonstrates routine scientific exploration of a compound's potential by investigating alternative disease targets and delivery mechanisms.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,517 |
|---|---|
| Title | Compounds for treating corona virus infection |
| Assignee(s) | NLC Pharma Ltd |