Neurotherapeutic Applications of Antiviral Compounds

Publication ID: 24-11857517_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Neurotherapeutic Applications of Antiviral Compounds,” Published Technical Disclosure No. 24-11857517_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857517_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,517.

Summary of the Inventive Concept

The present inventive concept leverages the core technology of the original patent to develop novel therapeutic approaches for treating neurological disorders, neuroinflammation, neurodegenerative diseases, and anxiety disorders, thereby expanding the scope of the original invention.

Background and Problem Solved

The original patent disclosed compounds and compositions useful for treating coronavirus-associated diseases. However, the patent did not explore the potential of these compounds in addressing neurological disorders. The present inventive concept addresses this limitation by applying the core technology to develop novel therapeutic approaches for neurological disorders, thereby providing a new avenue for treatment.

Detailed Description of the Inventive Concept

The inventive concept involves the use of compounds represented by Formula I, which exhibit antiviral and/or anti-inflammatory effects on neurological cells. These compounds can be administered via various routes, including nasal sprays, to prevent neuroinflammation and treat neurodegenerative diseases. The compounds can also be formulated with neuroprotective agents to enhance their therapeutic efficacy. Furthermore, the inventive concept encompasses the use of nanoparticle formulations and transcranial magnetic stimulation devices to deliver the compounds to the brain, thereby enhancing their bioavailability and therapeutic effect.

Novelty and Inventive Step

The present inventive concept is novel and non-obvious over the original patent because it applies the core technology to an entirely new field of neurological disorders, which was not contemplated in the original patent. The inventive concept involves the identification of new therapeutic applications, new routes of administration, and new formulations, which are not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may involve the use of different compounds, different routes of administration, or different formulations. For example, the compounds may be administered orally or intravenously, or they may be formulated with other neuroprotective agents or anti-inflammatory compounds. Additionally, the inventive concept may be adapted for use in treating other neurological disorders, such as Parkinson's disease or Alzheimer's disease.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the field of neurological disorders, which is a large and growing market. The inventive concept may be developed into novel therapeutic products, such as nasal sprays or nanoparticle formulations, which could be marketed to pharmaceutical companies or healthcare providers. The market potential is substantial, given the high incidence and prevalence of neurological disorders, and the lack of effective treatments for these disorders.

CPC Classifications

SectionClassGroup
A A61 A61K31/122
A A61 A61K9/0053
A A61 A61K9/0095
A A61 A61K9/127
A A61 A61K9/2009
A A61 A61K9/2013
A A61 A61K9/2018
A A61 A61K9/2054
A A61 A61K9/2095
A A61 A61K9/282
A A61 A61K9/2833
A A61 A61K9/4833
A A61 A61K9/4858
A A61 A61K9/4866
A A61 A61K31/198
A A61 A61K31/222
A A61 A61K31/381
A A61 A61K31/40
A A61 A61K31/422
A A61 A61K31/433
A A61 A61K31/454
A A61 A61K31/513
A A61 A61K31/536
A A61 A61K36/30
A A61 A61P31/14
A A61 A61K2236/51

Field of Art

Pharmaceutical chemistry and drug delivery systems, specifically focused on antiviral compounds and neurological therapeutic interventions, with expertise in molecular formulation, drug targeting, and neurological disease treatment

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in pharmaceutical sciences or medicinal chemistry, possessing knowledge of drug repurposing, neurological disease mechanisms, and advanced drug delivery technologies

Obviousness Rationale

A PHOSITA would recognize the natural extension of the source patent's antiviral compounds into neurological applications based on the known anti-inflammatory and cellular protective properties of the original compounds. The disclosed neurotherapeutic variations represent predictable applications of the core molecular technology, utilizing standard pharmaceutical engineering techniques for expanding therapeutic uses. The PTD demonstrates routine scientific exploration of a compound's potential by investigating alternative disease targets and delivery mechanisms.

Obvious Combinations & Variations

Source Patent Element
Compounds with antiviral properties represented by Formula I
PTD Variation
Application of Formula I compounds to neurological disorder treatment
Obviousness Reasoning
Predictable extension of known compound's cellular interaction mechanisms to neurological contexts, leveraging inherent anti-inflammatory properties
Source Patent Element
Coronavirus treatment method using specific molecular structures
PTD Variation
Nasal spray delivery for neuroinflammation prevention
Obviousness Reasoning
Known pharmaceutical technique of adapting drug delivery routes, representing a standard design choice for improving compound bioavailability
Source Patent Element
Base molecular compound with potential systemic interactions
PTD Variation
Nanoparticle formulation for enhanced brain targeting
Obviousness Reasoning
Well-established pharmaceutical engineering approach for improving drug penetration, representing a known technique for expanding compound utility
Source Patent Element
Compounds with potential cellular interaction capabilities
PTD Variation
Combination with neuroprotective agents for enhanced therapeutic effect
Obviousness Reasoning
Routine pharmaceutical optimization strategy of combining complementary therapeutic agents to improve overall treatment efficacy
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857517, a person having ordinary skill in the art would find the neurotherapeutic applications and delivery mechanisms disclosed herein to be obvious variations of the original antiviral compound technology. The present disclosure represents a predictable application of known molecular structures to alternative therapeutic contexts, utilizing standard pharmaceutical engineering techniques that would be apparent to a skilled practitioner in the field.

Original Patent Information

Patent NumberUS 11,857,517
TitleCompounds for treating corona virus infection
Assignee(s)NLC Pharma Ltd