Novel Applications of Compounds for Treating Diverse Diseases
Legal Citation
Summary of the Inventive Concept
This inventive concept expands the therapeutic scope of compounds originally designed for treating coronavirus-associated diseases to address unmet needs in chronic obstructive pulmonary disease, skin conditions, gastrointestinal disorders, neurodegenerative diseases, and ocular diseases.
Background and Problem Solved
The original patent disclosed compounds effective against coronavirus-associated diseases. However, there remains a significant unmet need for effective treatments in various other disease areas. This inventive concept bridges this gap by applying the core technology to new therapeutic applications, leveraging the compounds' potential to address diverse diseases.
Detailed Description of the Inventive Concept
The inventive concept involves administering compounds represented by Formula I, wherein R1-R6 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and carbonyl, to patients suffering from chronic obstructive pulmonary disease, skin conditions, gastrointestinal disorders, neurodegenerative diseases, or ocular diseases. The compounds' unique properties enable them to interact with specific biological targets, leading to therapeutic benefits in these disease areas.
Novelty and Inventive Step
The novelty of this inventive concept lies in the unexpected application of the compounds to new disease areas, beyond their original indication for coronavirus-associated diseases. The inventive step is the recognition of the compounds' potential to address diverse diseases, which was not obvious from the original patent.
Alternative Embodiments and Variations
Alternative embodiments of this inventive concept may involve modifying the compounds' structures, adjusting dosing regimens, or combining them with other therapeutic agents to enhance efficacy or minimize side effects. Variations may include using different formulations, such as topical creams or oral tablets, to target specific disease areas.
Potential Commercial Applications and Market
This inventive concept has significant commercial potential, as it addresses unmet needs in multiple disease areas, including chronic obstructive pulmonary disease, skin conditions, gastrointestinal disorders, neurodegenerative diseases, and ocular diseases. The target market includes pharmaceutical companies, biotechnology firms, and research institutions seeking to develop innovative treatments for these diseases.
CPC Classifications
| Section | Class | Group |
|---|---|---|
| A | A61 | A61K31/122 |
| A | A61 | A61K9/0053 |
| A | A61 | A61K9/0095 |
| A | A61 | A61K9/127 |
| A | A61 | A61K9/2009 |
| A | A61 | A61K9/2013 |
| A | A61 | A61K9/2018 |
| A | A61 | A61K9/2054 |
| A | A61 | A61K9/2095 |
| A | A61 | A61K9/282 |
| A | A61 | A61K9/2833 |
| A | A61 | A61K9/4833 |
| A | A61 | A61K9/4858 |
| A | A61 | A61K9/4866 |
| A | A61 | A61K31/198 |
| A | A61 | A61K31/222 |
| A | A61 | A61K31/381 |
| A | A61 | A61K31/40 |
| A | A61 | A61K31/422 |
| A | A61 | A61K31/433 |
| A | A61 | A61K31/454 |
| A | A61 | A61K31/513 |
| A | A61 | A61K31/536 |
| A | A61 | A61K36/30 |
| A | A61 | A61P31/14 |
| A | A61 | A61K2236/51 |
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical chemistry and drug development, specifically focusing on therapeutic compounds for treating various disease states, with expertise in molecular design, drug formulation, and therapeutic applications across multiple medical domains
Person of Ordinary Skill (PHOSITA) Profile
A pharmaceutical researcher with advanced degree (PhD/PharmD), extensive knowledge of medicinal chemistry, understanding of molecular structure-activity relationships, and experience in drug repurposing and therapeutic adaptation strategies
Obviousness Rationale
A PHOSITA would recognize that the compounds originally developed for coronavirus treatment possess inherent structural flexibility and potential multi-target therapeutic capabilities. The disclosed variations represent predictable extensions of the source patent's core molecular framework by systematically exploring alternative disease applications. The technical similarities in molecular structure and potential biological interactions suggest that adapting these compounds to new therapeutic contexts would be a routine optimization process for an experienced pharmaceutical researcher.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,517 |
|---|---|
| Title | Compounds for treating corona virus infection |
| Assignee(s) | NLC Pharma Ltd |