Novel Applications of Compounds for Treating Diverse Diseases

Publication ID: 24-11857517_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Novel Applications of Compounds for Treating Diverse Diseases,” Published Technical Disclosure No. 24-11857517_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857517_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,517.

Summary of the Inventive Concept

This inventive concept expands the therapeutic scope of compounds originally designed for treating coronavirus-associated diseases to address unmet needs in chronic obstructive pulmonary disease, skin conditions, gastrointestinal disorders, neurodegenerative diseases, and ocular diseases.

Background and Problem Solved

The original patent disclosed compounds effective against coronavirus-associated diseases. However, there remains a significant unmet need for effective treatments in various other disease areas. This inventive concept bridges this gap by applying the core technology to new therapeutic applications, leveraging the compounds' potential to address diverse diseases.

Detailed Description of the Inventive Concept

The inventive concept involves administering compounds represented by Formula I, wherein R1-R6 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and carbonyl, to patients suffering from chronic obstructive pulmonary disease, skin conditions, gastrointestinal disorders, neurodegenerative diseases, or ocular diseases. The compounds' unique properties enable them to interact with specific biological targets, leading to therapeutic benefits in these disease areas.

Novelty and Inventive Step

The novelty of this inventive concept lies in the unexpected application of the compounds to new disease areas, beyond their original indication for coronavirus-associated diseases. The inventive step is the recognition of the compounds' potential to address diverse diseases, which was not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept may involve modifying the compounds' structures, adjusting dosing regimens, or combining them with other therapeutic agents to enhance efficacy or minimize side effects. Variations may include using different formulations, such as topical creams or oral tablets, to target specific disease areas.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential, as it addresses unmet needs in multiple disease areas, including chronic obstructive pulmonary disease, skin conditions, gastrointestinal disorders, neurodegenerative diseases, and ocular diseases. The target market includes pharmaceutical companies, biotechnology firms, and research institutions seeking to develop innovative treatments for these diseases.

CPC Classifications

SectionClassGroup
A A61 A61K31/122
A A61 A61K9/0053
A A61 A61K9/0095
A A61 A61K9/127
A A61 A61K9/2009
A A61 A61K9/2013
A A61 A61K9/2018
A A61 A61K9/2054
A A61 A61K9/2095
A A61 A61K9/282
A A61 A61K9/2833
A A61 A61K9/4833
A A61 A61K9/4858
A A61 A61K9/4866
A A61 A61K31/198
A A61 A61K31/222
A A61 A61K31/381
A A61 A61K31/40
A A61 A61K31/422
A A61 A61K31/433
A A61 A61K31/454
A A61 A61K31/513
A A61 A61K31/536
A A61 A61K36/30
A A61 A61P31/14
A A61 A61K2236/51

Field of Art

Pharmaceutical chemistry and drug development, specifically focusing on therapeutic compounds for treating various disease states, with expertise in molecular design, drug formulation, and therapeutic applications across multiple medical domains

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical researcher with advanced degree (PhD/PharmD), extensive knowledge of medicinal chemistry, understanding of molecular structure-activity relationships, and experience in drug repurposing and therapeutic adaptation strategies

Obviousness Rationale

A PHOSITA would recognize that the compounds originally developed for coronavirus treatment possess inherent structural flexibility and potential multi-target therapeutic capabilities. The disclosed variations represent predictable extensions of the source patent's core molecular framework by systematically exploring alternative disease applications. The technical similarities in molecular structure and potential biological interactions suggest that adapting these compounds to new therapeutic contexts would be a routine optimization process for an experienced pharmaceutical researcher.

Obvious Combinations & Variations

Source Patent Element
Compounds with Formula I targeting coronavirus infection
PTD Variation
Applying identical molecular structure to treat chronic obstructive pulmonary disease
Obviousness Reasoning
Predictable result based on structural similarity and known respiratory disease mechanisms
Source Patent Element
Shikonin-based compounds with potential anti-inflammatory properties
PTD Variation
Topical administration for skin condition treatment
Obviousness Reasoning
Known anti-inflammatory mechanisms and established dermatological drug delivery techniques
Source Patent Element
Molecular framework with diverse substituent options (R1-R6)
PTD Variation
Modifying compound for neurodegenerative disease treatment
Obviousness Reasoning
Finite set of known molecular modifications and established drug repurposing strategies
Source Patent Element
Glycoside derivatives of original compounds
PTD Variation
Developing combination therapies for multiple disease states
Obviousness Reasoning
Routine pharmaceutical optimization using known chemical modification techniques
Source Patent Element
Original compound's broad structural adaptability
PTD Variation
Creating targeted formulations for different administration routes
Obviousness Reasoning
Predictable pharmaceutical engineering approach using standard drug development protocols
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857517, a person having ordinary skill in the art would find the variations disclosed herein to be obvious extensions of the original molecular framework. The systematic exploration of alternative therapeutic applications represents a predictable progression of the source patent's core technological contribution, thereby rendering subsequent claims involving similar molecular adaptations anticipated and non-patentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,517
TitleCompounds for treating corona virus infection
Assignee(s)NLC Pharma Ltd