Intranasal Analgesia for Veterinary and Aquatic Applications

Publication ID: 24-11857520_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Intranasal Analgesia for Veterinary and Aquatic Applications,” Published Technical Disclosure No. 24-11857520_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857520_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,520.

Summary of the Inventive Concept

The inventive concept extends the core technology of preservative-free intranasal lidocaine compositions to treat pain and discomfort in veterinary and aquatic applications, providing a rapid onset of analgesia and alleviating stress in animals.

Background and Problem Solved

The original patent disclosed a preservative-free intranasal composition for treating pain associated with trigeminal neuralgia, facial neuropathic pain, and other human conditions. However, there is a need for effective and safe analgesic solutions in veterinary and aquatic medicine, where current treatments often have limited efficacy or undesirable side effects. The new inventive concept addresses this gap by adapting the core technology to address pain and discomfort in animals, improving their welfare and quality of life.

Detailed Description of the Inventive Concept

The inventive concept comprises a preservative-free intranasal composition of lidocaine in a multi-dose spray container, administered to animals via a mechanical pump device. The composition provides a rapid onset of analgesia, alleviating pain and discomfort associated with various veterinary and aquatic conditions, such as respiratory diseases in livestock, stress in poultry, dental procedures in companion animals, exercise-induced muscle soreness in horses, and aquatic animal husbandry. The mechanical pump device ensures accurate dosing and minimizes waste, while the preservative-free composition reduces the risk of adverse reactions and promotes animal safety.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious in its application of preservative-free intranasal lidocaine compositions to veterinary and aquatic medicine, providing a unique solution for pain management in animals. The inventive step lies in the adaptation of the core technology to address specific challenges and needs in these industries, demonstrating a new and unexpected use of the original patent's composition and device.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include variations in the composition, such as different concentrations of lidocaine or the addition of other analgesic agents. The mechanical pump device could also be modified to accommodate different animal species or sizes. Furthermore, the inventive concept could be integrated with other veterinary or aquatic medical devices, such as inhalers or injectors, to provide a comprehensive pain management solution.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the veterinary and aquatic medicine markets, where there is a growing demand for effective and safe analgesic solutions. The market for veterinary pain management is projected to grow at a CAGR of 8% from 2023 to 2028, driven by increasing pet ownership and advances in veterinary care. The inventive concept could also find applications in aquatic animal husbandry, where pain management is critical for animal welfare and productivity. The target industries include veterinary pharmaceutical companies, animal health organizations, and aquatic animal husbandry operations.

CPC Classifications

SectionClassGroup
A A61 A61K31/167
A A61 A61K9/0043
A A61 A61M11/00
A A61 A61M2210/0618

Field of Art

Medical drug delivery systems, specifically intranasal anesthetic compositions and multi-dose spray delivery mechanisms for pain management across human and veterinary applications

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical formulation specialist with expertise in drug delivery systems, nasal spray technologies, and pain management compositions, holding advanced degrees in pharmacy, pharmacology, or biomedical engineering with knowledge of preservative-free formulations and mechanical spray devices

Obviousness Rationale

A PHOSITA would recognize that the core technological elements of preservative-free intranasal lidocaine compositions are readily adaptable across different medical domains, with the mechanical multi-dose spray device representing a universal delivery mechanism that can be applied to various therapeutic contexts. The source patent's fundamental innovation of a preservative-free lidocaine nasal spray provides a clear technological template that can be systematically extended to veterinary and aquatic applications by applying standard pharmaceutical engineering principles. The PTD's variations represent predictable extrapolations of the source patent's core technological concept, demonstrating how a skilled practitioner would naturally explore alternative implementation domains for an established medical delivery system.

Obvious Combinations & Variations

Source Patent Element
Preservative-free intranasal lidocaine composition in a multi-dose spray device
PTD Variation
Applying the same composition and delivery mechanism to veterinary pain management scenarios
Obviousness Reasoning
Known technique of adapting pharmaceutical formulations across medical domains, with predictable results of pain management efficacy
Source Patent Element
Mechanical multi-dose nasal spray pump providing 0.04 ml to 0.2 ml volume
PTD Variation
Modifying pump device dimensions to accommodate different animal species and sizes
Obviousness Reasoning
Routine engineering design variation with finite, predictable modifications based on target species' anatomical requirements
Source Patent Element
Lidocaine as a local sodium channel blocker for pain treatment
PTD Variation
Extending lidocaine's analgesic properties to veterinary respiratory and stress management applications
Obviousness Reasoning
Well-established pharmacological principle of applying consistent molecular mechanisms across biological systems
Source Patent Element
Treating neuropathic and neurological pain conditions
PTD Variation
Expanding pain management approach to exercise-induced muscle soreness and dental procedures in animals
Obviousness Reasoning
Logical extension of known pain management strategies using established pharmaceutical formulation
Source Patent Element
Unit dose providing 5-20 mg lidocaine per nasal spray application
PTD Variation
Adjusting dosage ranges to match different animal metabolic requirements
Obviousness Reasoning
Routine pharmaceutical optimization using standard dose-scaling methodologies
35 U.S.C. § 103 Summary: Based on US Patent 11857520's fundamental disclosure of a preservative-free intranasal lidocaine composition, the present publication demonstrates that the claimed variations in veterinary and aquatic pain management would have been obvious to a person having ordinary skill in the art at the time of invention, as the core technological elements represent predictable extensions of the source patent's innovative delivery mechanism and pharmaceutical composition.

Original Patent Information

Patent NumberUS 11,857,520
TitleTherapeutic composition of intranasal lidocaine
Assignee(s)Nortic Holdings Inc.