Applying Cholestasis Biomarkers to Industrial and Environmental Applications

Publication ID: 24-11857523_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Applying Cholestasis Biomarkers to Industrial and Environmental Applications,” Published Technical Disclosure No. 24-11857523_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857523_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,523.

Summary of the Inventive Concept

The present inventive concept leverages the core technology of cholestasis biomarkers to develop novel solutions for optimizing crop yields, detecting environmental pollutants, monitoring industrial processes, predicting corrosion, and identifying therapeutic compounds.

Background and Problem Solved

The original patent disclosed methods for treating cholestatic diseases, specifically PBC and PSC. However, the present inventive concept recognizes that cholestasis biomarkers have broader applications beyond medicine. By applying these biomarkers to industrial and environmental contexts, the inventive concept addresses the limitations of current methods in these fields, providing more accurate and efficient solutions.

Detailed Description of the Inventive Concept

The inventive concept comprises a range of systems and methods that utilize cholestasis biomarkers to drive innovation in various industries. For instance, a system for optimizing crop yields involves detecting cholestasis-related biomarkers in soil to adjust fertilizer application. Similarly, a method for detecting environmental pollutants involves analyzing samples for cholestasis biomarkers to generate reports on pollutant levels. The inventive concept also encompasses devices for monitoring industrial processes, predicting corrosion, and identifying novel therapeutic compounds.

Novelty and Inventive Step

The inventive concept introduces a novel application of cholestasis biomarkers to industrial and environmental contexts, departing from the original patent's focus on medical treatments. The inventive step lies in recognizing the broader potential of these biomarkers and adapting them to address specific challenges in these new fields.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include adapting the systems and methods to specific industries, such as oil and gas or aerospace, or integrating the biomarkers with existing technologies, like IoT sensors or machine learning algorithms. Variations could also involve using different types of biomarkers or developing new detection methods.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential across various industries, including agriculture, environmental monitoring, industrial process control, and pharmaceuticals. The market for these solutions is substantial, with potential customers including farmers, environmental agencies, manufacturers, and pharmaceutical companies.

CPC Classifications

SectionClassGroup
A A61 A61K31/192
A A61 A61K45/06
A A61 A61P37/06

Field of Art

Medical biotechnology, pharmaceutical research, and biomarker detection with expertise in cholestatic disease diagnostics and interdisciplinary applications of biological markers

Person of Ordinary Skill (PHOSITA) Profile

A researcher or scientist with advanced degree in biochemistry, pharmacology, or biomedical engineering, possessing knowledge of biomarker technologies, diagnostic methodologies, and cross-disciplinary applications of biological indicators

Obviousness Rationale

A PHOSITA would recognize that cholestasis biomarkers represent a versatile diagnostic tool with potential applications beyond medical treatment. The PTD's extension of cholestasis biomarkers into industrial and environmental contexts represents a predictable and logical progression of existing scientific knowledge, leveraging established detection methodologies to solve problems in diverse technological domains.

Obvious Combinations & Variations

Source Patent Element
Cholestasis biomarker detection method for medical diagnostics
PTD Variation
Applying cholestasis biomarker detection to soil analysis for agricultural optimization
Obviousness Reasoning
Known sensor and detection technologies can be readily adapted to measure biomarkers in different substrates, representing a predictable application of existing diagnostic techniques
Source Patent Element
Identification of biological indicators related to liver disease
PTD Variation
Using cholestasis biomarkers to detect environmental pollutants
Obviousness Reasoning
Biomarker sensitivity and specificity make them suitable for detecting molecular changes across different environmental contexts, a logical extension of existing diagnostic principles
Source Patent Element
Pharmaceutical compound screening methodology
PTD Variation
Screening compounds using cholestasis biomarkers for industrial and therapeutic applications
Obviousness Reasoning
Compound screening techniques are well-established and can be easily modified to detect molecular interactions across different research domains
Source Patent Element
Understanding molecular indicators of physiological disruption
PTD Variation
Monitoring industrial processes through biomarker detection in process fluids
Obviousness Reasoning
Translating molecular detection techniques from medical to industrial contexts represents a straightforward technological adaptation with predictable implementation strategies
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in the Published Technical Disclosure would have been obvious to a Person Having Ordinary Skill In The Art at the time of invention, based on the teachings of US Patent 11857523. The PTD demonstrates that cholestasis biomarker detection represents a versatile technological approach with predictable applications across multiple domains, rendering subsequent claims involving similar methodological extensions prima facie obvious.

Original Patent Information

Patent NumberUS 11,857,523
TitleMethods of treatment of cholestatic diseases
Assignee(s)Genfit