Synergistic Cholestatic Disease Management System

Publication ID: 24-11857523_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Cholestatic Disease Management System,” Published Technical Disclosure No. 24-11857523_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857523_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,523.

Summary of the Inventive Concept

A novel system integrating elafibranor treatment with AI, IoT, blockchain, and new materials to provide personalized, data-driven management of cholestatic diseases

Background and Problem Solved

The original patent addressed the treatment of cholestatic diseases, specifically PBC and PSC, with elafibranor. However, it did not provide a comprehensive solution for monitoring, predicting, and adapting to disease progression. The new inventive concept addresses this limitation by incorporating distinct technologies to create a more powerful system

Detailed Description of the Inventive Concept

The system comprises a wearable device for tracking patient biomarkers, an AI-powered analytics module for predicting disease progression, and a personalized treatment planner integrating elafibranor administration with lifestyle recommendations. Additionally, the system incorporates machine learning algorithms for optimizing elafibranor treatment, a blockchain-based platform for secure data management, a smart pillbox system for ensuring patient adherence, and a novel biomaterial composition for oral delivery of elafibranor

Novelty and Inventive Step

The new claims introduce a synergistic combination of distinct technologies, providing a holistic approach to cholestatic disease management. The inventive step lies in the integration of these technologies to create a more effective and personalized treatment system

Alternative Embodiments and Variations

Alternative embodiments could include different AI algorithms, various wearable devices, or alternative blockchain platforms. Variations could also include integrating the system with electronic health records or telemedicine platforms

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of personalized medicine, digital health, and disease management

CPC Classifications

SectionClassGroup
A A61 A61K31/192
A A61 A61K45/06
A A61 A61P37/06

Field of Art

Medical technology and pharmaceutical treatment systems, specifically focused on cholestatic disease management, involving pharmacological interventions, medical device integration, and personalized treatment technologies

Person of Ordinary Skill (PHOSITA) Profile

A skilled practitioner with expertise in pharmaceutical sciences, medical device engineering, data analytics, and clinical treatment protocols, possessing advanced knowledge of drug delivery systems, patient monitoring technologies, and computational healthcare solutions

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies with existing pharmaceutical treatments represents a predictable and logical extension of current medical management strategies. The combination of elafibranor treatment with AI-driven analytics, IoT monitoring, and advanced drug delivery systems follows established trends in personalized medicine. The technical variations disclosed represent incremental improvements using known technological approaches to enhance treatment effectiveness and patient outcomes.

Obvious Combinations & Variations

Source Patent Element
Elafibranor treatment for cholestatic diseases with specific administration protocols
PTD Variation
AI-powered treatment optimization using machine learning algorithms to customize elafibranor dosage and timing
Obviousness Reasoning
Personalized medicine techniques are well-established, and applying computational analysis to pharmaceutical treatment represents a predictable application of known data science techniques to medical management
Source Patent Element
Oral administration of cholestatic disease medication
PTD Variation
Nanoparticle-based biomaterial composition for enhanced elafibranor oral delivery with integrated microsensor monitoring
Obviousness Reasoning
Advanced drug delivery technologies are a standard approach in pharmaceutical research, and combining targeted delivery with monitoring represents an obvious technological progression
Source Patent Element
Treatment method for cholestatic diseases like PBC
PTD Variation
Blockchain-based clinical trial data management platform tracking elafibranor administration and patient responses
Obviousness Reasoning
Secure, transparent medical data tracking is a known technological solution, and applying blockchain to clinical research represents a straightforward technological integration
Source Patent Element
Pharmaceutical composition for treating cholestatic diseases
PTD Variation
IoT-enabled smart pillbox system for medication adherence tracking and patient monitoring
Obviousness Reasoning
Patient compliance technologies are well-established, and creating connected medical devices to support treatment protocols is a predictable technological evolution
35 U.S.C. § 103 Summary: Based on US Patent 11857523 and the accompanying Published Technical Disclosure, a person having ordinary skill in the art would find the disclosed technological variations obvious and non-inventive. The integration of digital technologies with existing pharmaceutical treatment protocols represents a predictable application of known techniques to enhance medical management, thereby rendering potential derivative claims obvious and non-patentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,523
TitleMethods of treatment of cholestatic diseases
Assignee(s)Genfit