Agricultural Applications of Cholestasis Treatment Technology

Publication ID: 24-11857523_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Agricultural Applications of Cholestasis Treatment Technology,” Published Technical Disclosure No. 24-11857523_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857523_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,523.

Summary of the Inventive Concept

The present invention applies the core technology of cholestasis treatment to agricultural fields, enabling the prevention of crop yield loss, treatment of fungal infections, and improvement of soil fertility.

Background and Problem Solved

The original patent addressed the treatment of cholestatic diseases, specifically PBC and PSC. However, the present invention recognizes that the underlying principles of cholestasis treatment can be applied to agricultural fields, where soil health issues and fungal infections significantly impact crop yields. The new inventive concept addresses these limitations by providing a system for predicting crop yields, treating fungal infections, monitoring soil health, improving soil fertility, and optimizing irrigation systems.

Detailed Description of the Inventive Concept

The new claims describe a system for predicting crop yields by detecting changes in soil pH and applying a treatment composition to prevent cholestasis-induced yield loss. Another embodiment involves treating fungal infections in agricultural fields using a composition comprising elafibranor and a fungicide. The device for monitoring soil health detects changes in bile acid precursor C4 levels and alerts farmers to potential soil health issues. The method for improving soil fertility administers a composition comprising elafibranor and a nutrient supplement to promote healthy microbial growth and increase crop yields. Finally, the system for optimizing irrigation systems adjusts schedules to prevent waterlogged soil and promote healthy plant growth.

Novelty and Inventive Step

The new claims introduce a novel application of cholestasis treatment technology to agricultural fields, which is non-obvious compared to the original patent's focus on human diseases. The use of elafibranor in agricultural contexts and the integration of sensors and modules for monitoring and treating soil health issues are innovative and unanticipated.

Alternative Embodiments and Variations

Alternative embodiments may include using different sensors or modules, varying the composition of the treatment composition, or adapting the system for use in different types of agricultural fields or crops. Variations may also include integrating the inventive concept with existing agricultural technologies or practices.

Potential Commercial Applications and Market

The agricultural applications of cholestasis treatment technology have significant commercial potential in the agricultural industry, particularly in the areas of crop yield management, soil health monitoring, and fungal infection treatment. The target market includes farmers, agricultural companies, and organizations focused on sustainable agriculture.

CPC Classifications

SectionClassGroup
A A61 A61K31/192
A A61 A61K45/06
A A61 A61P37/06

Field of Art

Pharmaceutical and agricultural biotechnology, with expertise in pharmacological compound applications, disease treatment methodologies, and agricultural biological interventions

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in biochemistry, pharmacology, or agricultural sciences, capable of understanding complex molecular interactions, drug repurposing strategies, and interdisciplinary technology transfer

Obviousness Rationale

A skilled practitioner would recognize the inherent potential for extending the molecular mechanisms of elafibranor beyond human cholestasis treatment to agricultural applications. The fundamental properties of the compound that interact with biological systems suggest predictable adaptations across different biological contexts. The PTD demonstrates a logical extension of the source patent's core technology by applying similar intervention strategies to soil and plant health management.

Obvious Combinations & Variations

Source Patent Element
Composition comprising elafibranor for treating cholestatic diseases
PTD Variation
Using elafibranor as a treatment component for agricultural fungal infections and soil health management
Obviousness Reasoning
Known pharmacological compounds often have broad biological activity, and a PHOSITA would recognize potential cross-domain applications based on molecular interaction principles
Source Patent Element
Method of administering therapeutic compositions in various formulations
PTD Variation
Developing agricultural application methods using similar delivery mechanisms for soil treatment
Obviousness Reasoning
Pharmaceutical formulation techniques are directly transferable to agricultural intervention strategies, representing a predictable technological adaptation
Source Patent Element
Detection of physiological changes related to cholestasis
PTD Variation
Implementing sensor technologies to monitor soil pH and bile acid precursor levels
Obviousness Reasoning
Diagnostic and monitoring techniques are universally applicable across biological systems, representing a known technique for technological translation
Source Patent Element
Treatment of specific pathological conditions through molecular intervention
PTD Variation
Preventing crop yield loss through targeted biological interventions
Obviousness Reasoning
Molecular-level disease prevention strategies are conceptually similar across biological domains, suggesting an obvious technological extension
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857523 and the published technical disclosure, a person of ordinary skill in the art would find the agricultural applications of cholestasis treatment technology obvious and non-inventive. The disclosed variations represent predictable extensions of known pharmaceutical intervention strategies into agricultural biotechnology, utilizing substantially identical molecular mechanisms and diagnostic principles.

Original Patent Information

Patent NumberUS 11,857,523
TitleMethods of treatment of cholestatic diseases
Assignee(s)Genfit