Baclofen-based Solutions for Diverse Industries

Publication ID: 24-11857524_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Baclofen-based Solutions for Diverse Industries,” Published Technical Disclosure No. 24-11857524_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857524_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,524.

Summary of the Inventive Concept

The present inventive concept leverages the core technology of stable oral suspensions of baclofen to address unmet needs in various industries, including veterinary medicine, aquaculture, and agriculture, offering novel solutions for chronic pain management, muscle spasticity reduction, and crop yield improvement.

Background and Problem Solved

The original patent disclosed stable oral suspensions of baclofen for human use, but its applications were limited to pharmaceutical compositions for oral administration. The present inventive concept expands the scope of the original technology to address pressing problems in new industries, where the need for effective, safe, and convenient solutions is evident.

Detailed Description of the Inventive Concept

The inventive concept comprises a system, method, or composition that utilizes the stable oral suspension of baclofen or a pharmaceutically acceptable salt thereof at a concentration of equal to or more than about 2 mg/mL. In the veterinary medicine field, the inventive concept provides a system for treating chronic pain in companion animals, featuring a veterinary-friendly administration device. In aquaculture, the composition includes a fish-friendly excipient, enabling the safe and effective administration of baclofen to fish. In agriculture, the inventive concept encompasses a device for delivering the stable oral suspension to a target area of a plant, incorporating a micro-irrigation system and a plant growth-promoting agent, as well as a method for improving crop yields by applying the suspension to the soil or foliage of a crop.

Novelty and Inventive Step

The new claims introduce novel applications and use cases for the stable oral suspension of baclofen, which are not obvious from the original patent. The inventive concept's value lies in its ability to adapt the core technology to address specific needs in diverse industries, thereby expanding the scope of the original invention.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include different administration devices, excipients, or delivery systems tailored to specific industries or applications. Variations of the composition may involve the use of different concentrations of baclofen or the incorporation of additional active ingredients to enhance efficacy or safety.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the veterinary medicine, aquaculture, and agriculture industries, where there is a growing demand for innovative, effective, and safe solutions. The market for these applications is substantial, with opportunities for partnerships, licensing agreements, and product development collaborations.

Field of Art

Pharmaceutical formulations, specifically liquid pharmaceutical suspensions with a focus on drug stability, delivery systems, and multi-industry applications of pharmaceutical compounds

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical scientist or formulation engineer with expertise in drug suspension preparation, excipient selection, and cross-industry drug delivery techniques, holding at least a master's degree with practical experience in pharmaceutical development

Obviousness Rationale

A PHOSITA would recognize that the stable baclofen suspension disclosed in the source patent provides a foundational technology that can be readily adapted to different application contexts. The core technological innovation of maintaining baclofen stability at specific concentrations enables predictable extensions into veterinary, aquaculture, and agricultural domains. The PTD's variations represent logical extrapolations of the original suspension technology by applying known formulation principles to solve industry-specific challenges.

Obvious Combinations & Variations

Source Patent Element
Stable liquid suspension of baclofen at concentrations of 2 mg/mL or more
PTD Variation
Veterinary administration system for chronic pain management in companion animals
Obviousness Reasoning
Adapting a pharmaceutical formulation to veterinary applications is a predictable variation using known drug delivery techniques, representing a standard design choice for expanding pharmaceutical utility
Source Patent Element
Pharmaceutically acceptable excipients including anti-foaming agents and pH adjusting agents
PTD Variation
Fish-friendly excipient for aquaculture applications of baclofen suspension
Obviousness Reasoning
Modifying excipient selection for specific biological environments is a routine optimization process for a PHOSITA, involving standard pharmaceutical formulation strategies
Source Patent Element
Stable aqueous suspension with pH range between 4 to 8
PTD Variation
Micro-irrigation delivery system for applying baclofen suspension to plant systems
Obviousness Reasoning
Translating a stable pharmaceutical suspension into an agricultural delivery mechanism represents a predictable extension of the original formulation technology using known drug delivery and agricultural application principles
Source Patent Element
Stable liquid pharmaceutical composition suitable for oral administration
PTD Variation
Method for improving crop yields by applying baclofen suspension to soil or plant foliage
Obviousness Reasoning
Exploring alternative biological applications of a stable pharmaceutical compound is a standard scientific approach, representing an obvious investigation of potential novel uses based on established formulation characteristics
35 U.S.C. § 103 Summary: Based on US Patent 11857524's disclosure of a stable baclofen suspension, the present publication demonstrates that a Person Having Ordinary Skill In The Art would find the disclosed variations obvious, as they represent predictable extensions of the fundamental suspension technology through routine pharmaceutical formulation techniques and standard cross-industry adaptation strategies.

Original Patent Information

Patent NumberUS 11,857,524
TitleStable oral suspensions of baclofen
Assignee(s)ANI Pharmaceuticals, Inc.