Personalized Cachexia Treatment and Monitoring System

Publication ID: 24-11857525_0006_PTD
Published: October 28, 2025
Category:Direct Improvements & Enhancements

Legal Citation

pr1or.art Inc., “Personalized Cachexia Treatment and Monitoring System,” Published Technical Disclosure No. 24-11857525_0006_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857525_0006_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,525.

Summary of the Inventive Concept

A comprehensive system for personalized treatment and real-time monitoring of cachexia in patients undergoing surgery, utilizing customized immunonutrition supplements, wearable sensors, and machine learning algorithms to optimize treatment outcomes and reduce healthcare costs.

Background and Problem Solved

Cachexia, a severe body wasting condition, is a common complication of surgery, cancer, and infection. The original patent disclosed compositions and methods for treating or preventing surgery-induced cachexia. However, the existing approach has limitations, including a one-size-fits-all treatment approach and lack of real-time monitoring. The new inventive concept addresses these limitations by providing a personalized treatment system that adapts to individual patient needs and continuously monitors cachexia biomarkers.

Detailed Description of the Inventive Concept

The system comprises a patient profiling module, a nutrition supplement selection module, and an administration module. The patient profiling module identifies a patient's cachexia risk level and medical history. The nutrition supplement selection module selects a customized immunonutrition supplement based on the patient's risk level and medical history. The administration module ensures timely and accurate administration of the supplement. Additionally, a wearable sensor and data processing unit monitor cachexia biomarkers in real-time, providing alerts to healthcare providers when biomarkers exceed predetermined thresholds. A machine learning algorithm analyzes patient data to generate personalized cachexia risk profiles and predict treatment outcomes.

Novelty and Inventive Step

The new inventive concept introduces a paradigm shift from a one-size-fits-all approach to personalized treatment and real-time monitoring. The use of machine learning algorithms, wearable sensors, and customized immunonutrition supplements represents a significant departure from the original patent's composition-based approach. The inventive step lies in the integration of these components to create a comprehensive system that adapts to individual patient needs and optimizes treatment outcomes.

Alternative Embodiments and Variations

Alternative embodiments of the system could include the use of different types of sensors, such as implantable or ingestible sensors, or the integration of additional data sources, such as electronic health records or genomic data. Variations of the system could be designed for specific patient populations, such as pediatric or geriatric patients, or for different types of surgery or medical conditions.

Potential Commercial Applications and Market

The personalized cachexia treatment and monitoring system has significant commercial potential in the healthcare industry, particularly in the areas of surgical care, oncology, and nutrition therapy. The system could be marketed to hospitals, clinics, and healthcare providers, offering a competitive advantage in terms of improved treatment outcomes, reduced healthcare costs, and enhanced patient care.

Field of Art

Medical nutrition, surgical oncology, and personalized medical technology with expertise in immunonutrition, patient monitoring systems, and data-driven treatment optimization

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced training in biomedical engineering, clinical nutrition, or medical informatics, possessing knowledge of nutritional interventions, medical device design, and data analysis techniques

Obviousness Rationale

A PHOSITA would recognize that the source patent's cachexia treatment approach using immunonutrition supplements naturally extends to a more comprehensive personalized monitoring system. The technical variations represent predictable combinations of known medical technologies, including sensor monitoring, machine learning risk assessment, and adaptive supplement dosing strategies.

Obvious Combinations & Variations

Source Patent Element
Specialized immunonutrition supplement with specific L-arginine, omega-3 fatty acids, and nucleotide compositions
PTD Variation
Customized supplement selection module that dynamically adjusts supplement composition based on patient risk profile
Obviousness Reasoning
Routine optimization of nutritional interventions using patient-specific data represents a predictable application of personalized medicine principles
Source Patent Element
Treatment method for surgery-induced cachexia in bladder cancer patients
PTD Variation
Integration of wearable sensors and machine learning algorithms to monitor and predict cachexia progression
Obviousness Reasoning
Applying real-time monitoring and predictive analytics to existing treatment protocols is a known technique in medical technology for improving patient outcomes
Source Patent Element
Fixed dosage ranges for immunonutrition supplement components
PTD Variation
Dynamic dosage adjustment method based on patient response and biomarker monitoring
Obviousness Reasoning
Adaptive dosing strategies are a standard approach in medical treatment, representing an obvious extension of fixed-dosage treatment protocols
Source Patent Element
Composition targeting myeloid-derived suppressor cells and pro-inflammatory cytokines
PTD Variation
Synergistic blend formulation with enhanced targeting of inflammatory markers
Obviousness Reasoning
Incremental improvements in nutritional supplement composition through synergistic ingredient combinations are predictable to a skilled practitioner
Source Patent Element
Surgical patient treatment method
PTD Variation
Comprehensive system integrating patient profiling, supplement selection, and real-time monitoring
Obviousness Reasoning
Systematic integration of existing medical technologies represents a logical and obvious approach to improving treatment protocols
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857525, a person of ordinary skill in the art would find the claimed variations in the published technical disclosure to be obvious extensions of existing cachexia treatment methodologies. The systematic integration of personalized monitoring, adaptive supplementation, and predictive analytics represents a predictable combination of known medical technologies that would be readily conceived by a skilled practitioner seeking to optimize patient treatment outcomes.

Original Patent Information

Patent NumberUS 11,857,525
TitleTreatment or prevention of surgery-induced cachexia and/or expression of myeloid-derived suppressor cells and pro-inflammatory cytokines
Assignee(s)SOCIÉTÉ DES PRODUITS NESTLÉ S.A.