Synergistic Treatment and Prevention of Surgery-Induced Cachexia through AI-Powered Personalized Nutrition and Advanced Technologies

Publication ID: 24-11857525_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Treatment and Prevention of Surgery-Induced Cachexia through AI-Powered Personalized Nutrition and Advanced Technologies,” Published Technical Disclosure No. 24-11857525_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857525_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,525.

Summary of the Inventive Concept

The present disclosure relates to a comprehensive system for treating and preventing surgery-induced cachexia, leveraging synergistic combinations of AI, IoT, blockchain, and nanotechnology with specialized immunonutrition supplements to provide personalized and targeted interventions.

Background and Problem Solved

Surgery-induced cachexia is a severe and debilitating condition that affects millions of patients worldwide. The original patent disclosed compositions and methods for treating or preventing cachexia using specialized immunonutrition supplements. However, these approaches have limitations, such as lack of personalization, limited efficacy, and inadequate data management. The present inventive concept addresses these limitations by integrating advanced technologies to provide a more effective and comprehensive solution.

Detailed Description of the Inventive Concept

The system comprises a specialized immunonutrition supplement administered to a patient, which is combined with an AI-powered personalized nutrition planning module that generates a customized dietary plan based on the patient's genomic profile and medical history. Additionally, the system incorporates IoT-enabled sensors to track the patient's nutritional intake and physiological responses, which are integrated with a blockchain-based health record system to ensure secure and transparent data management. Furthermore, the system includes a composition for preventing or treating surgery-induced cachexia, comprising a synergistic blend of L-arginine, omega-3 fatty acids, and vitamin A, and a nanocarrier system for targeted delivery of the nutrients to the affected tissues.

Novelty and Inventive Step

The present inventive concept introduces a novel and non-obvious combination of AI, IoT, blockchain, and nanotechnology with specialized immunonutrition supplements, providing a synergistic and personalized approach to treating and preventing surgery-induced cachexia. The inventive concept's novelty lies in its ability to integrate multiple advanced technologies to provide a comprehensive solution that addresses the limitations of existing approaches.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include using machine learning algorithms to predict the risk of cachexia, or incorporating decentralized blockchain-based networks to share and analyze data from multiple healthcare providers. Variations of the composition may include different ratios of L-arginine, omega-3 fatty acids, and vitamin A, or the use of alternative nanocarrier systems.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the healthcare industry, particularly in the fields of oncology, surgery, and nutrition. The system's ability to provide personalized and targeted interventions makes it an attractive solution for healthcare providers and patients seeking more effective and efficient treatments for surgery-induced cachexia.

Field of Art

Medical nutrition, oncological supportive care, and personalized medical technology with a focus on surgical patient nutritional interventions and cachexia management

Person of Ordinary Skill (PHOSITA) Profile

A medical nutritionist or clinical researcher with expertise in nutritional supplementation, surgical patient care, advanced medical technologies, and interdisciplinary approaches to patient treatment strategies

Obviousness Rationale

A PHOSITA would recognize that integrating advanced technologies with established nutritional intervention strategies represents a natural progression in personalized medical care. The core nutritional supplement composition remains substantially similar to the source patent, with technological augmentation providing enhanced monitoring and personalization. The fundamental scientific principles of targeted nutritional supplementation for surgery-induced cachexia remain consistent, with technological additions representing predictable evolutionary improvements.

Obvious Combinations & Variations

Source Patent Element
Specialized immunonutrition supplement containing L-arginine, omega-3 fatty acids, and specific dosage ranges
PTD Variation
Adding nanocarrier delivery system and AI-powered personalization of nutritional supplement
Obviousness Reasoning
Targeted drug delivery and personalized medicine are well-established techniques in medical research, representing a predictable application of known technological approaches to existing nutritional interventions
Source Patent Element
Method of treating surgery-induced cachexia in specific patient populations
PTD Variation
Incorporating IoT sensors and blockchain for comprehensive patient monitoring and data management
Obviousness Reasoning
Digital health technologies represent a logical extension of medical treatment protocols, providing enhanced tracking and personalization of existing medical interventions
Source Patent Element
Nutritional supplement targeting surgical patients with specific medical conditions
PTD Variation
Machine learning algorithms for predicting cachexia risk and generating personalized intervention plans
Obviousness Reasoning
Predictive analytics and personalized medical approaches are standard techniques in contemporary medical research, representing an obvious technological enhancement to existing treatment methodologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857525 and the comprehensive technological extensions disclosed herein, a person having ordinary skill in the art would find the proposed variations obvious and predictable. The combination of known nutritional supplement compositions with emerging digital health technologies represents a straightforward and non-inventive approach to enhancing surgical patient care and cachexia management.

Original Patent Information

Patent NumberUS 11,857,525
TitleTreatment or prevention of surgery-induced cachexia and/or expression of myeloid-derived suppressor cells and pro-inflammatory cytokines
Assignee(s)SOCIÉTÉ DES PRODUITS NESTLÉ S.A.