Personalized Surgery-Induced Cachexia Prevention and Reversal System

Publication ID: 24-11857525_0010_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Surgery-Induced Cachexia Prevention and Reversal System,” Published Technical Disclosure No. 24-11857525_0010_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857525_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,525.

Summary of the Inventive Concept

A next-generation system for personalized prevention and reversal of surgery-induced cachexia, leveraging machine learning, wearable devices, and tailored immunonutrition supplements to improve patient outcomes.

Background and Problem Solved

The original patent addressed the treatment or prevention of surgery-induced cachexia using specialized immunonutrition supplements. However, it did not provide personalized solutions for patients at risk, nor did it offer real-time monitoring and feedback. The new inventive concept addresses these limitations by integrating machine learning-based predictive models, wearable devices, and tailored supplements to provide a more effective and patient-centric approach.

Detailed Description of the Inventive Concept

The system comprises a machine learning-based predictive model that identifies patients at risk of surgery-induced cachexia. Based on the model's output, a tailored immunonutrition supplement is administered to the patient. The system further includes a wearable device that monitors muscle mass and provides real-time feedback to the patient. Additionally, the system can optimize supplement dosing based on a patient's genomic profile and medical history. The wearable device can also transmit data to a healthcare provider, enabling real-time monitoring and prevention of cachexia-induced muscle loss.

Novelty and Inventive Step

The new claims introduce a paradigm shift in the prevention and reversal of surgery-induced cachexia by incorporating machine learning, wearable devices, and personalized supplements. The inventive step lies in the integration of these components to provide a proactive, patient-centric approach that was not possible with the original patent's composition-based solution.

Alternative Embodiments and Variations

Alternative embodiments of the system could include the use of different machine learning algorithms, additional biomarkers for predicting cachexia risk, or alternative wearable devices for monitoring muscle mass. Variations of the system could also include different types of immunonutrition supplements or different dosing regimens.

Potential Commercial Applications and Market

The personalized surgery-induced cachexia prevention and reversal system has significant commercial potential in the healthcare industry, particularly in the fields of oncology, cardiology, and orthopedics. The system could be marketed as a premium service for patients undergoing high-risk surgeries, providing a competitive advantage for healthcare providers and improving patient outcomes.

Field of Art

Medical nutrition, oncology, and digital health technologies with expertise in patient-specific interventions for metabolic disorders and surgical recovery

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degrees in nutrition science, biomedical engineering, or clinical medicine, possessing knowledge of immunonutrition, machine learning applications in healthcare, and wearable medical monitoring technologies

Obviousness Rationale

A PHOSITA would recognize that integrating digital monitoring technologies with the existing immunonutrition supplement approach represents a predictable technological evolution. The source patent's foundational work on cachexia prevention provides a clear technical framework that naturally extends to personalized, data-driven interventions. The combination of known nutritional supplements with machine learning and wearable monitoring represents an incremental improvement consistent with standard medical technology development strategies.

Obvious Combinations & Variations

Source Patent Element
Specialized immunonutrition supplement with specific L-arginine, omega-3 fatty acids, and nucleotide compositions
PTD Variation
Machine learning-based personalized dosing of the same nutritional components based on patient genomic profile and medical history
Obviousness Reasoning
Personalized medicine approaches are a known technique for optimizing therapeutic interventions, and applying machine learning to existing nutritional supplement protocols represents a predictable technological extension
Source Patent Element
Method of treating surgery-induced cachexia in specific patient populations
PTD Variation
Adding real-time muscle mass monitoring through wearable device technology
Obviousness Reasoning
Continuous patient monitoring is a standard approach in medical interventions, and integrating sensor technologies with existing treatment protocols is a routine design optimization
Source Patent Element
Composition for preventing muscle wasting in surgical patients
PTD Variation
Cloud-based platform for tracking patient data and providing predictive risk assessment
Obviousness Reasoning
Digital health platforms that aggregate and analyze patient data are a well-established technological approach for enhancing medical interventions
Source Patent Element
Specific dosage ranges for nutritional supplements
PTD Variation
Dynamic dosage adjustment based on real-time physiological monitoring
Obviousness Reasoning
Adaptive dosing strategies are a known technique in precision medicine, representing an obvious extension of fixed-dosage pharmaceutical approaches
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857525, the claimed variations in personalized cachexia prevention represent obvious modifications to the existing nutritional intervention approach. A person of ordinary skill would recognize that integrating machine learning, wearable monitoring, and personalized dosing strategies constitutes a predictable technological evolution of the foundational nutritional supplement method, thereby rendering such variations obvious under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,525
TitleTreatment or prevention of surgery-induced cachexia and/or expression of myeloid-derived suppressor cells and pro-inflammatory cytokines
Assignee(s)SOCIÉTÉ DES PRODUITS NESTLÉ S.A.