Personalized BPH/LUTS Treatment Systems via Synergistic Combinations of Mast Cell Inhibition and Advanced Technologies

Publication ID: 24-11857531_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Personalized BPH/LUTS Treatment Systems via Synergistic Combinations of Mast Cell Inhibition and Advanced Technologies,” Published Technical Disclosure No. 24-11857531_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857531_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,531.

Summary of the Inventive Concept

The present inventive concept integrates mast cell inhibition with AI, IoT, blockchain, and nanotechnology to create personalized treatment systems for BPH/LUTS, enabling real-time monitoring, optimized treatment outcomes, and secure data management.

Background and Problem Solved

Benign prostatic hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS) are prevalent conditions affecting millions of men worldwide. The original patent disclosed combination therapies comprising mast cell inhibitors and histamine receptor antagonists, but lacked personalized treatment approaches and secure data management. The present inventive concept addresses these limitations by incorporating advanced technologies to create a more comprehensive and effective treatment system.

Detailed Description of the Inventive Concept

The inventive concept comprises a mast cell inhibitor, a histamine receptor antagonist, and a blockchain-based patient monitoring platform for personalized treatment optimization. The system utilizes machine learning algorithms trained on a dataset of patient responses to predict treatment outcomes and optimize dosages. Additionally, the system incorporates a wearable device for real-time symptom monitoring and an AI-powered analytics module for providing personalized treatment recommendations. The composition for treating BPH/LUTS includes a mast cell stabilizer, a histamine receptor antagonist, and nanoparticles for targeted delivery to the prostate gland.

Novelty and Inventive Step

The present inventive concept's novelty lies in the synergistic combination of mast cell inhibition with AI, IoT, blockchain, and nanotechnology, which enables personalized treatment approaches and secure data management. The inventive step is the integration of these distinct technologies to create a more comprehensive and effective treatment system for BPH/LUTS.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different machine learning algorithms, varying types of nanoparticles for targeted delivery, or the incorporation of additional advanced technologies such as augmented reality for patient education and engagement. Variations may also include different wearable device designs or the use of alternative blockchain platforms for secure data management.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the pharmaceutical and medical device industries, with a target market including healthcare providers, researchers, and patients suffering from BPH/LUTS. The system's ability to provide personalized treatment approaches and secure data management addresses a significant unmet need in the market, offering a competitive advantage over existing treatment options.

Field of Art

Medical therapeutics, specifically urology and pharmacological treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS), with expertise in pharmaceutical composition design, drug delivery systems, and patient monitoring technologies

Person of Ordinary Skill (PHOSITA) Profile

A medical researcher or pharmaceutical scientist with advanced degree (PhD/MD), specialized knowledge in urology, pharmacology, and digital health technologies, familiar with emerging treatment strategies for urological conditions

Obviousness Rationale

A PHOSITA would recognize that integrating digital monitoring technologies and advanced drug delivery systems with established pharmaceutical treatments represents a predictable evolution of BPH/LUTS management. The source patent's foundational combination therapy approach naturally suggests opportunities for technological enhancement and personalization. The proposed variations represent logical extensions of existing treatment paradigms using well-understood technological approaches.

Obvious Combinations & Variations

Source Patent Element
Combination therapy using mast cell inhibitors and histamine receptor antagonists
PTD Variation
Adding nanoparticle-based targeted drug delivery to enhance treatment precision
Obviousness Reasoning
Targeted drug delivery is a known technique in pharmaceutical science, representing a predictable optimization of existing treatment methods to improve localized therapeutic efficacy
Source Patent Element
Treatment method for BPH/LUTS using specific pharmaceutical compounds
PTD Variation
Incorporating machine learning algorithms to predict and optimize treatment outcomes
Obviousness Reasoning
Applying data analytics and predictive modeling to medical treatment is a standard approach for personalizing therapeutic interventions, representing an obvious technological enhancement
Source Patent Element
Pharmaceutical composition for treating urological conditions
PTD Variation
Implementing blockchain-based patient data management system
Obviousness Reasoning
Secure digital health data management is a recognized technological solution for improving patient care tracking and research collaboration, representing a logical technological progression
Source Patent Element
Treatment method targeting mast cell function
PTD Variation
Integrating wearable device technology for real-time symptom monitoring
Obviousness Reasoning
Remote patient monitoring is a well-established approach in medical technology, providing predictable benefits for chronic condition management
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857531 and the present technical disclosure, a person of ordinary skill in the art would find the proposed variations involving digital health technologies, personalized treatment optimization, and advanced drug delivery systems to be obvious extensions of existing pharmaceutical treatment strategies for BPH/LUTS, thereby rendering potential patent claims obvious under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,531
TitleCombination mast cell inhibition for treatment of BPH/LUTS
Assignee(s)Northwestern University