Personalized Friedreich Ataxia Treatment and Prediction System

Publication ID: 24-11857532_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Personalized Friedreich Ataxia Treatment and Prediction System,” Published Technical Disclosure No. 24-11857532_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857532_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,532.

Summary of the Inventive Concept

A synergistic combination of TfR1 palmitoylation-increasing drugs, wearable devices, blockchain-based platforms, AI-powered predictive models, and IoT-enabled devices to provide personalized treatment plans and optimize therapeutic responses for Friedreich ataxia patients.

Background and Problem Solved

Friedreich ataxia is a debilitating degenerative disease with limited treatment options. The original patent disclosed methods of treating and predicting therapeutic responses in Friedreich ataxia patients using TfR1 palmitoylation-increasing drugs. However, these methods have limitations in terms of personalized treatment and data management. The new inventive concept addresses these limitations by integrating distinct technologies to create a more powerful system.

Detailed Description of the Inventive Concept

The system comprises a wearable device that monitors a patient's gait and limb ataxia, a blockchain-based platform that securely stores and analyzes the patient's health data, and an AI-powered predictive model that forecasts therapeutic responses to TfR1 palmitoylation-increasing drugs. The platform is integrated with an IoT-enabled device that monitors and adjusts the patient's environment to optimize the therapeutic response. The system provides a personalized treatment plan based on the analysis of the patient's health data and forecasts therapeutic responses.

Novelty and Inventive Step

The new inventive concept introduces a synergistic combination of TfR1 palmitoylation-increasing drugs, wearable devices, blockchain-based platforms, AI-powered predictive models, and IoT-enabled devices, which is not obvious from the original patent. The integration of these distinct technologies provides a novel and non-obvious solution for personalized treatment and prediction of therapeutic responses in Friedreich ataxia patients.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of wearable devices, such as implantable sensors or mobile applications, or the integration of additional technologies, such as machine learning algorithms or natural language processing. Variations of the system could be designed for different types of degenerative diseases or patient populations.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the healthcare industry, particularly in the areas of personalized medicine and digital health. The system could be marketed to pharmaceutical companies, healthcare providers, and patients suffering from Friedreich ataxia and other degenerative diseases.

Original Patent Information

Patent NumberUS 11,857,532
TitleTreatment and prediction of therapeutic responses in patients suffering from Friedreich ataxia
Assignee(s)INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), The Assistance Publique—Hôpitaux de Paris (APHP), FONDATION IMAGINE