Personalized Obesity Prevention and Treatment System

Publication ID: 24-11857533_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Obesity Prevention and Treatment System,” Published Technical Disclosure No. 24-11857533_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857533_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,533.

Summary of the Inventive Concept

A next-generation system integrating steroid sulfatase inhibitors with machine learning algorithms and genomic data for tailored treatment of obesity and lipid-related metabolic disorders, offering a paradigm shift in personalized medicine.

Background and Problem Solved

The original patent disclosed a functional composition for preventing or treating obesity or lipid-related metabolic disease using irosustat. However, the treatment outcomes varied among individuals, and there was a need for a more personalized approach. The new inventive concept addresses this limitation by incorporating machine learning algorithms, genomic data, and wearable devices to provide real-time monitoring and tailored treatment.

Detailed Description of the Inventive Concept

The system comprises a steroid sulfatase inhibitor, a machine learning algorithm, and a genomic data repository. The algorithm predicts individualized treatment outcomes based on genomic data and real-time monitoring of lipid metabolism using wearable devices. The system also includes a composition for synergistic prevention or treatment of obesity and lipid-related metabolic disease, comprising a steroid sulfatase inhibitor and a gut microbiome modulator. Additionally, a device for non-invasive, transdermal delivery of the steroid sulfatase inhibitor is included. The computer-implemented method for predicting the efficacy of the steroid sulfatase inhibitor in treating obesity or lipid-related metabolic disease based on patient-specific data and machine learning algorithms completes the system.

Novelty and Inventive Step

The new claims introduce a paradigm shift by integrating machine learning algorithms, genomic data, and wearable devices to provide personalized treatment outcomes, which is not obvious from the original patent. The combination of these elements and the specific implementation details demonstrate a novel and non-obvious inventive concept.

Alternative Embodiments and Variations

Alternative embodiments may include using different types of machine learning algorithms, incorporating additional data sources such as electronic health records, or developing new formulations of the steroid sulfatase inhibitor. Variations of the system could include targeting specific populations, such as pediatric or geriatric patients, or integrating with existing healthcare infrastructure.

Potential Commercial Applications and Market

The personalized obesity prevention and treatment system has significant commercial potential in the healthcare industry, particularly in the fields of precision medicine and digital health. The target market includes pharmaceutical companies, healthcare providers, and patients seeking personalized treatment options for obesity and lipid-related metabolic disorders.

Field of Art

Pharmaceutical biotechnology, metabolic disease treatment, machine learning in personalized medicine, with expertise in steroid sulfatase inhibitors and metabolic disorder interventions

Person of Ordinary Skill (PHOSITA) Profile

A researcher or clinician with advanced degrees in pharmaceutical sciences, biotechnology, or computational biology, possessing knowledge of drug development, machine learning algorithms, and personalized treatment strategies

Obviousness Rationale

A PHOSITA would recognize that integrating machine learning with existing pharmaceutical interventions for metabolic disorders represents a predictable extension of current personalized medicine approaches. The combination of steroid sulfatase inhibitors with computational predictive methods follows established trends in precision medicine. The technical elements disclosed in the PTD represent incremental improvements that would be obvious to a skilled practitioner seeking to optimize treatment outcomes.

Obvious Combinations & Variations

Source Patent Element
Pharmaceutical composition for treating obesity using steroid sulfatase inhibitor (irosustat)
PTD Variation
Adding machine learning algorithm for predicting individualized treatment outcomes
Obviousness Reasoning
Applying machine learning to personalize pharmaceutical interventions is a known technique in precision medicine, representing a predictable application of computational methods to existing pharmaceutical treatments
Source Patent Element
Method for treating lipid-related metabolic diseases
PTD Variation
Incorporating wearable device for real-time metabolic monitoring
Obviousness Reasoning
Using wearable technology for continuous health monitoring is a well-established approach in medical technology, providing a predictable enhancement to existing treatment methodologies
Source Patent Element
Pharmaceutical composition for metabolic disorder treatment
PTD Variation
Adding gut microbiome modulator to steroid sulfatase inhibitor
Obviousness Reasoning
Combining pharmaceutical agents with complementary mechanisms is a standard approach in drug development, representing an obvious optimization strategy for treatment efficacy
Source Patent Element
Pharmaceutical composition administered to treat obesity
PTD Variation
Developing non-invasive transdermal delivery device
Obviousness Reasoning
Alternative drug delivery methods are routinely explored by pharmaceutical researchers as a means of improving patient compliance and treatment effectiveness
Source Patent Element
Method of treating metabolic disorders
PTD Variation
Implementing genomic data-based predictive algorithms
Obviousness Reasoning
Utilizing genetic information to predict treatment outcomes is a standard approach in personalized medicine, representing an obvious application of computational techniques to pharmaceutical interventions
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857533 and the subsequent Published Technical Disclosure, a person of ordinary skill in the art would find the claimed variations obvious, as they represent predictable combinations of known pharmaceutical, computational, and medical monitoring technologies. The disclosed system integrates steroid sulfatase inhibition with machine learning and personalized monitoring techniques through a series of obvious technological extensions that would be apparent to a skilled practitioner in the field of metabolic disease treatment.

Original Patent Information

Patent NumberUS 11,857,533
TitleComposition for preventing or treating obesity or lipid-related metabolic disorders
Assignee(s)Nexyon Biotech Co., Ltd.