Synergistic Ocular Pain Management System

Publication ID: 24-11857537_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Ocular Pain Management System,” Published Technical Disclosure No. 24-11857537_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857537_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,537.

Summary of the Inventive Concept

The present inventive concept integrates prostacyclin antagonists with advanced technologies, such as AI, IoT, blockchain, and novel materials, to create a comprehensive system for treating and managing ocular pain, offering enhanced efficacy, personalized treatment, and improved patient outcomes.

Background and Problem Solved

The original patent disclosed the use of prostacyclin antagonists for treating ocular surface nociception. However, the existing approaches lack the ability to provide personalized treatment regimens, real-time monitoring, and secure data tracking. The present inventive concept addresses these limitations by combining the prostacyclin antagonists with cutting-edge technologies to create a more powerful and effective system.

Detailed Description of the Inventive Concept

The synergistic ocular pain management system comprises a prostacyclin antagonist, an AI-powered diagnostic module, a blockchain-secured platform, and IoT-enabled communication modules. The system enables personalized treatment regimens based on patient-specific data, real-time monitoring of ocular surface nociception, and secure tracking of patient responses to therapy. The system can be integrated with wearable devices, novel material compositions for ocular implants, and smart contact lenses to provide a comprehensive solution for ocular pain management.

Novelty and Inventive Step

The present inventive concept introduces a novel combination of prostacyclin antagonists with advanced technologies, providing a synergistic effect that enhances the efficacy and personalization of ocular pain treatment. The integration of AI, IoT, blockchain, and novel materials with prostacyclin antagonists is new and non-obvious compared to the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include integrating the prostacyclin antagonists with other technologies, such as machine learning algorithms, virtual reality, or 3D printing. Variations of the system could be designed for specific ocular conditions, such as dry eye disease or glaucoma, or for use in different patient populations, such as pediatric or geriatric patients.

Potential Commercial Applications and Market

The synergistic ocular pain management system has significant commercial potential in the ophthalmology and healthcare industries. The system could be marketed to pharmaceutical companies, medical device manufacturers, and healthcare providers, offering a comprehensive solution for ocular pain management and improved patient outcomes.

Field of Art

Ophthalmology and pharmaceutical formulations, specifically focused on ocular surface pain management and drug delivery technologies

Person of Ordinary Skill (PHOSITA) Profile

A medical researcher or pharmaceutical scientist with expertise in ophthalmological treatments, drug delivery systems, and emerging medical technologies, holding advanced degrees in pharmacology, biomedical engineering, or related fields

Obviousness Rationale

A person skilled in the art would recognize that integrating advanced technologies with existing pharmaceutical treatments is a predictable approach to enhancing medical interventions. The combination of prostacyclin antagonists with AI, IoT, and monitoring technologies represents a logical extension of existing treatment paradigms. The PTD's proposed system builds upon the foundational drug delivery method described in the source patent by adding technological layers that improve patient monitoring and treatment personalization.

Obvious Combinations & Variations

Source Patent Element
Topical ophthalmic formulation for treating dry eye disease using prostacyclin antagonists
PTD Variation
AI-powered diagnostic module for identifying optimal treatment regimens based on patient-specific data
Obviousness Reasoning
Personalized medicine and data-driven treatment selection are well-established techniques in pharmaceutical research, making the integration of AI diagnostic tools with existing drug delivery methods a predictable and obvious improvement
Source Patent Element
Method of administering prostacyclin antagonists in various formulations
PTD Variation
Wearable device with integrated prostacyclin antagonist dispenser and IoT communication module
Obviousness Reasoning
Smart drug delivery systems that enable real-time monitoring and controlled release are known techniques in medical technology, representing an obvious technological progression for improving patient treatment
Source Patent Element
Topical ophthalmic formulation for ocular surface treatment
PTD Variation
Blockchain-secured platform for tracking patient responses and generating predictive treatment models
Obviousness Reasoning
Secure data tracking and predictive analytics are standard approaches in medical research, making the blockchain integration a logical and obvious extension of existing treatment monitoring practices
Source Patent Element
Pharmaceutical composition for ocular surface treatment
PTD Variation
Novel material composition for ocular implants with controlled-release prostacyclin antagonist
Obviousness Reasoning
Controlled-release drug delivery systems are well-known in pharmaceutical research, and adapting the existing drug formulation to an implantable format represents a predictable technological advancement
Source Patent Element
Topical administration of prostacyclin antagonists
PTD Variation
Smart contact lens with integrated prostacyclin antagonist and monitoring microchip
Obviousness Reasoning
Combining drug delivery with smart medical devices is a recognized trend in medical technology, making the integration of drug-coated surfaces with monitoring capabilities an obvious technological progression
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857537 and the published technical disclosure, a person having ordinary skill in the art would find the proposed variations obvious and predictable extensions of existing ocular pain management technologies. The combination of prostacyclin antagonists with advanced diagnostic, monitoring, and delivery technologies represents a logical progression that would be apparent to a skilled practitioner, thereby rendering potential claims to such combinations unpatentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,537
TitleUse of prostacyclin antagonists for treating ocular surface nociception
Assignee(s)JENIVISION INC.