Personalized Ocular Pain Management System

Publication ID: 24-11857537_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Ocular Pain Management System,” Published Technical Disclosure No. 24-11857537_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857537_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,537.

Summary of the Inventive Concept

A next-generation system for personalized ocular pain management, integrating wearable sensors, micro-dosing devices, and AI-driven analytics to provide targeted and sustained relief from ocular pain.

Background and Problem Solved

The original patent disclosed the use of prostacyclin antagonists for treating ocular surface nociception, but it had limitations in terms of personalized treatment and real-time monitoring. The present inventive concept addresses these limitations by introducing a wearable sensor and micro-dosing device that work in tandem to detect and respond to ocular surface nociception in real-time, providing a more effective and personalized treatment approach.

Detailed Description of the Inventive Concept

The system comprises a portable, wearable sensor that detects changes in ocular surface nociception and transmits data to a micro-dosing device, which delivers a tailored amount of a prostacyclin antagonist to the affected eye. The system can be integrated with AI-driven analytics to predict and prevent ocular pain, and can be used in conjunction with novel formulations of prostacyclin antagonists that release the antagonist in response to changes in ocular surface pH. Additionally, the system can be expanded to include smart contact lenses and neural interfaces that provide real-time relief from ocular discomfort.

Novelty and Inventive Step

The present inventive concept introduces a novel combination of wearable sensors, micro-dosing devices, and AI-driven analytics to provide personalized ocular pain management, which is not disclosed in the original patent. The use of wearable sensors and micro-dosing devices to detect and respond to ocular surface nociception in real-time is a significant departure from the original patent's approach, and the integration of AI-driven analytics provides an additional layer of sophistication and personalization.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different types of sensors, such as electroencephalography (EEG) or functional near-infrared spectroscopy (fNIRS), to detect changes in ocular surface nociception. The system could also be adapted for use in veterinary medicine, or integrated with other therapeutic modalities, such as electrical stimulation or phototherapy, to provide a more comprehensive treatment approach.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the ophthalmic industry, with potential applications in the treatment of dry eye disease, ocular surface injuries, and other conditions characterized by ocular pain. The system's ability to provide personalized and targeted relief from ocular pain could make it an attractive option for patients and clinicians alike, and its potential integration with AI-driven analytics could provide a competitive advantage in the market.

Field of Art

Ophthalmology and pharmaceutical drug delivery, specifically focused on ocular surface pain management and targeted drug delivery systems for treating dry eye disease and nociception

Person of Ordinary Skill (PHOSITA) Profile

A medical researcher or pharmaceutical engineer with expertise in ophthalmology, drug formulation, medical device design, and sensor technologies, holding advanced degrees in biomedical engineering, pharmacology, or related fields

Obviousness Rationale

A person of ordinary skill would recognize that the PTD's personalized ocular pain management system represents a predictable technological evolution of the source patent's prostacyclin antagonist treatment method. The integration of wearable sensors, micro-dosing devices, and AI-driven analytics provides a natural extension of the original patent's therapeutic approach by enhancing targeted drug delivery and real-time monitoring of ocular surface conditions. The technical variations demonstrate incremental improvements using known technologies and design principles within the field of ocular therapeutics.

Obvious Combinations & Variations

Source Patent Element
Topical ophthalmic formulation of prostacyclin antagonist for treating dry eye disease
PTD Variation
Wearable sensor and micro-dosing device for real-time detection and targeted drug delivery
Obviousness Reasoning
A PHOSITA would recognize that adding sensor-based monitoring and precision dosing represents a predictable technological improvement in drug administration, using known sensor and microfluidic technologies
Source Patent Element
Administering prostacyclin antagonist in various formulations
PTD Variation
Bioresponsive polymer formulation that releases antagonist based on ocular surface pH changes
Obviousness Reasoning
Smart drug delivery systems using responsive polymers are well-known in pharmaceutical engineering, making this variation an obvious design choice for improving targeted drug release
Source Patent Element
Topical administration of ocular pain treatment
PTD Variation
Smart contact lens with integrated sensor and drug-eluting layer
Obviousness Reasoning
Combining drug delivery mechanisms with wearable medical devices is a predictable solution for improving patient compliance and treatment effectiveness
Source Patent Element
Method of treating ocular surface nociception
PTD Variation
AI-driven analytics for predicting and preventing ocular pain based on sensor data
Obviousness Reasoning
Applying machine learning and predictive analytics to medical monitoring is a known technique for enhancing personalized treatment strategies
Source Patent Element
Pharmaceutical composition for ocular pain management
PTD Variation
Neural interface with brain-computer interaction for real-time pain detection and treatment
Obviousness Reasoning
Integrating neural monitoring technologies with drug delivery represents an incremental advancement using established neurotechnology principles
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857537 and the present published technical disclosure, a person of ordinary skill in the art would find the claimed variations obvious and anticipated, as the disclosed personalized ocular pain management system represents a predictable combination of known technologies in sensor-based drug delivery, responsive polymers, and AI-driven medical monitoring, thereby rendering subsequent patent claims obvious and non-patentable.

Original Patent Information

Patent NumberUS 11,857,537
TitleUse of prostacyclin antagonists for treating ocular surface nociception
Assignee(s)JENIVISION INC.