Pilocarpine-Brimonidine Compositions for Novel Applications
Legal Citation
Summary of the Inventive Concept
The present inventive concept expands the scope of pilocarpine-brimonidine compositions beyond ophthalmic applications, unlocking new possibilities for improving crop yields, reducing water evaporation, monitoring plant water stress, enhancing bioremediation, and improving skin hydration.
Background and Problem Solved
The original patent disclosed pilocarpine-brimonidine compositions for treating ophthalmic conditions. However, the limitations of these compositions in addressing other pressing problems in agriculture, environmental sustainability, and skin care remained unexplored. The present inventive concept addresses these limitations by applying the core technology to entirely new fields, providing innovative solutions to pressing problems.
Detailed Description of the Inventive Concept
The newly generated claims describe compositions and methods that leverage the synergistic effects of pilocarpine and brimonidine compounds in novel applications. For instance, claim 1 discloses a system for improving crop yield by enhancing photosynthesis and increasing water uptake. Claim 2 describes a method for reducing water evaporation from soil, while claim 3 outlines a device for monitoring plant water stress. Claims 4 and 5 detail compositions for bioremediation and skin hydration, respectively. These inventive concepts involve the administration of pilocarpine-brimonidine compositions to plants, soil, or skin, resulting in improved outcomes.
Novelty and Inventive Step
The novelty of the present inventive concept lies in the unexpected application of pilocarpine-brimonidine compositions to non-ophthalmic fields. The inventive step resides in the recognition of the compositions' potential to address specific problems in agriculture, environmental sustainability, and skin care, and the development of new methods and systems that realize this potential.
Alternative Embodiments and Variations
Alternative embodiments may include varying the ratio of pilocarpine to brimonidine compounds, using different salts or derivatives of these compounds, or combining them with other active ingredients. Variations may also involve modifying the composition's formulation, delivery method, or dosage to optimize its performance in different applications.
Potential Commercial Applications and Market
The present inventive concept has significant commercial potential in various industries, including agriculture, environmental sustainability, and skin care. The market for these applications is substantial, with the global agricultural technology market projected to reach $22.5 billion by 2025, the environmental remediation market expected to reach $123.8 billion by 2027, and the global skin care market forecasted to reach $131.8 billion by 2027.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical and biotechnology compositions, with expertise in drug delivery systems, formulation chemistry, and multi-compound biological interactions
Person of Ordinary Skill (PHOSITA) Profile
A professional with advanced degree in pharmaceutical sciences or chemistry, familiar with drug composition techniques, compound interactions, and cross-disciplinary applications of pharmaceutical compounds
Obviousness Rationale
A PHOSITA would recognize the inherent versatility of pilocarpine-brimonidine compositions beyond ophthalmic applications by understanding their fundamental molecular properties and biological interactions. The source patent establishes the compounds' efficacy and compatibility, which naturally suggests potential broader applications. The PTD's variations represent predictable extensions of the original compositional framework by applying known pharmacological principles to alternative domains.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,539 |
|---|---|
| Title | Gel ophthalmic formulations of pilocarpine and brimonidine compounds and related methods |
| Assignee(s) | Somerset Therapeutics, LLC |