Specialized Ophthalmic Formulations for Niche Environments

Publication ID: 24-11857539_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Specialized Ophthalmic Formulations for Niche Environments,” Published Technical Disclosure No. 24-11857539_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857539_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,539.

Summary of the Inventive Concept

The inventive concept relates to novel ophthalmic formulations of pilocarpine and brimonidine compounds tailored for specific, narrow market segments or unique operational environments, such as high-altitude, extreme temperatures, disaster relief, high-security, and space exploration.

Background and Problem Solved

The original patent disclosed gel ophthalmic formulations of pilocarpine and brimonidine compounds for treating ophthalmic conditions. However, these formulations may not be suitable for use in specialized environments, such as high-altitude or extreme temperatures, where the efficacy of the formulation may be compromised. The present inventive concept addresses this limitation by providing novel formulations adapted for use in these niche environments.

Detailed Description of the Inventive Concept

The inventive concept comprises a series of specialized ophthalmic formulations of pilocarpine and brimonidine compounds, each tailored for a specific niche environment. For example, a formulation for high-altitude environments may be designed to maintain efficacy at elevations above 10,000 feet, while a formulation for extreme temperatures may be adapted for use in temperatures below -20°C or above 40°C. The formulations may include specific combinations and concentrations of pilocarpine and brimonidine compounds, as well as additional components to enhance stability and efficacy in these environments.

Novelty and Inventive Step

The new claims provide a novel and non-obvious solution by adapting the original formulations for use in specialized environments, which was not contemplated in the original patent. The inventive step lies in the recognition of the need for specialized formulations and the development of specific compositions that address the unique challenges of these environments.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept may include formulations adapted for use in other niche environments, such as high-humidity or high-dust environments. Variations of the formulations may also include different concentrations or combinations of pilocarpine and brimonidine compounds, or the inclusion of additional components to enhance efficacy or stability.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the ophthalmic industry, particularly in the areas of high-altitude, extreme temperatures, disaster relief, high-security, and space exploration. The market for these specialized formulations is likely to be niche, but significant, and may include government agencies, military organizations, and private companies operating in these environments.

Original Patent Information

Patent NumberUS 11,857,539
TitleGel ophthalmic formulations of pilocarpine and brimonidine compounds and related methods
Assignee(s)Somerset Therapeutics, LLC