Adaptive Pemafibrate Dosing Regimens for Personalized Medicine

Publication ID: 24-11857540_0005_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Adaptive Pemafibrate Dosing Regimens for Personalized Medicine,” Published Technical Disclosure No. 24-11857540_0005_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857540_0005_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,540.

Summary of the Inventive Concept

A next-generation system for pemafibrate treatment, leveraging machine learning, artificial intelligence, and real-time biosensing to optimize dosing regimens for individual patients, ensuring safer and more effective treatment of dyslipidemia.

Background and Problem Solved

The original patent disclosed pemafibrate dosing regimens, but these were limited by a one-size-fits-all approach, neglecting individual patient differences and potential drug-drug interactions. The new inventive concept addresses this limitation by introducing adaptive dosing regimens that account for patient-specific OATP1B inhibitor interactions and utilize AI-driven predictive analytics.

Detailed Description of the Inventive Concept

The inventive concept comprises a database of patient-specific OATP1B inhibitor interactions, a machine learning algorithm to predict optimal pemafibrate doses, and a wearable device for real-time pemafibrate dosing monitoring. The system utilizes artificial intelligence to analyze patient medical histories, identify potential drug-drug interactions, and provide personalized treatment planning. A computer-implemented simulation engine enables healthcare providers to input patient-specific parameters and visualize dosing outcomes, while a cloud-based platform facilitates collaborative dosing decision support.

Novelty and Inventive Step

The new claims introduce a paradigm shift in pemafibrate treatment by integrating machine learning, artificial intelligence, and real-time biosensing to create adaptive dosing regimens. This approach is novel and non-obvious compared to the original patent, which relied on fixed dosing regimens.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, incorporation of additional patient data sources, or integration with electronic health records. Variations may involve adapting the system for other diseases or medications, or developing a mobile application for patient engagement and dosing reminders.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the personalized medicine market, with applications in dyslipidemia treatment, pharmacogenomics, and precision medicine. The target industries include pharmaceutical companies, healthcare providers, and medical technology firms.

Original Patent Information

Patent NumberUS 11,857,540
TitlePemafibrate dosing regimens
Assignee(s)KOWA COMPANY, LTD.