Synergistic Anemia Treatment Systems

Publication ID: 24-11857543_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Anemia Treatment Systems,” Published Technical Disclosure No. 24-11857543_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857543_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,543.

Summary of the Inventive Concept

Integrating HIF prolyl hydroxylase inhibitors with AI, IoT, blockchain, and nanomaterial technologies to create more effective and personalized anemia treatment systems.

Background and Problem Solved

The original patent disclosed compositions and methods for treating anemia using HIF prolyl hydroxylase inhibitors. However, the existing treatment methods have limitations in terms of dosing accuracy, patient data management, and treatment efficacy monitoring. The new inventive concept addresses these limitations by combining HIF prolyl hydroxylase inhibitors with distinct technologies to create a more powerful and personalized anemia treatment system.

Detailed Description of the Inventive Concept

The new inventive concept comprises four main components: (1) a HIF prolyl hydroxylase inhibitor, (2) an AI-powered dosing algorithm, (3) an IoT-enabled wearable device, and (4) a blockchain-based patient data management platform. The AI-powered dosing algorithm adjusts the dosage of the HIF prolyl hydroxylase inhibitor based on real-time patient data stored on the blockchain-based platform. The IoT-enabled wearable device monitors patient vital signs and transmits the data to a cloud-based server for analysis and personalized treatment recommendations. Additionally, the system can integrate a nanomaterial-based delivery system to enhance the bioavailability of the HIF prolyl hydroxylase inhibitor and a biomarker for monitoring treatment efficacy.

Novelty and Inventive Step

The new claims introduce the concept of integrating HIF prolyl hydroxylase inhibitors with AI, IoT, blockchain, and nanomaterial technologies, which is not disclosed in the original patent. The inventive step lies in the synergistic combination of these distinct technologies to create a more effective and personalized anemia treatment system.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include integrating the HIF prolyl hydroxylase inhibitor with other AI-powered algorithms, such as machine learning algorithms for predicting treatment outcomes or genomic analysis platforms for personalized treatment planning. Other variations could include using different types of IoT-enabled devices or blockchain-based platforms.

Potential Commercial Applications and Market

The synergistic anemia treatment systems have significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of personalized medicine and precision healthcare. The target market includes patients with chronic kidney disease, chemotherapy-induced anemia, and AIDS-related anemia, as well as healthcare providers and pharmaceutical companies.

Original Patent Information

Patent NumberUS 11,857,543
TitleCompositions and methods for treating anemia
Assignee(s)Akebia Therapeutics, Inc.