Synergistic Combinations for Corneal Endothelial Disease Treatment and Management

Publication ID: 24-11857544_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Combinations for Corneal Endothelial Disease Treatment and Management,” Published Technical Disclosure No. 24-11857544_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857544_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,544.

Summary of the Inventive Concept

A novel system integrating (T)EW-7197 with AI, IoT, blockchain, and new materials to provide a more effective and personalized treatment and management approach for corneal endothelial diseases

Background and Problem Solved

The original patent disclosed the use of (T)EW-7197 for treating or preventing corneal endothelial diseases. However, it had limitations in terms of tracking, monitoring, and personalizing treatment. The new inventive concept addresses these limitations by integrating (T)EW-7197 with distinct technologies to create a more powerful system

Detailed Description of the Inventive Concept

The new inventive concept comprises a pharmaceutical composition including (T)EW-7197, which is integrated with a blockchain-based tracking module, a wearable device for monitoring corneal endothelial cell density, and machine learning algorithms for predicting treatment efficacy. Additionally, the system incorporates a deep learning-based image analysis module, an AI-powered decision support system, and a decentralized IoT network for real-time monitoring. The system also enables personalized treatment through 3D-printed customized corneal implants with micro-sensors for real-time monitoring

Novelty and Inventive Step

The new claims introduce the synergistic combination of (T)EW-7197 with AI, IoT, blockchain, and new materials, which provides a non-obvious and novel solution for treating and managing corneal endothelial diseases

Alternative Embodiments and Variations

Alternative embodiments may include integrating the system with electronic health records, using different types of wearable devices, or incorporating additional AI-powered analytics modules. Variations may include using different pharmaceutical compositions or adapting the system for other ocular diseases

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the ophthalmology industry, particularly in the areas of personalized medicine, disease management, and medical device development. Target industries may include pharmaceutical companies, medical device manufacturers, and healthcare providers

Original Patent Information

Patent NumberUS 11,857,544
TitleComposition or method including (t)ew-7197 for treating or preventing corneal endothelial diseases
Assignee(s)SENJU PHARMACEUTICAL CO., LTD., THE DOSHISHA