FLT3 Mutation-Based Solutions for Industrial, Agricultural, and Environmental Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages the core technology of crenolanib to address novel applications in industrial air quality control, agricultural fungal infection prevention, water contamination removal, veterinary disease treatment, and pest population management.
Background and Problem Solved
The original patent focused on treating FLT3 mutated proliferative disorders in humans. However, the limitations of this approach lie in its narrow scope and lack of consideration for other industries and fields where FLT3 mutations could be exploited. This inventive concept addresses these limitations by applying the core technology to entirely new domains.
Detailed Description of the Inventive Concept
The inventive concept comprises novel systems and methods that utilize crenolanib or its salts to target FLT3 mutated particles, fungal strains, contaminants, pathogens, or pest populations in various industries. For instance, the air quality monitoring system detects FLT3 mutated particles and employs a crenolanib-based air purification unit to reduce their presence. Similarly, the agricultural fungicide applies a crenolanib-based solution to target FLT3 mutated fungal strains, preventing crop infections. The water supply system detects and removes FLT3 mutated contaminants using a crenolanib-based detection unit and removal unit. The veterinary therapeutic administers a crenolanib-based treatment to animals infected with FLT3 mutated pathogens. Lastly, the pest population management system monitors and controls FLT3 mutated pest populations in agricultural fields using a crenolanib-based detection unit and population control unit.
Novelty and Inventive Step
The novelty of this inventive concept lies in its application of crenolanib to entirely new industries and fields, which was not considered in the original patent. The inventive step is the recognition of the potential of crenolanib to address FLT3 mutations in these novel contexts, leading to the development of innovative systems and methods that provide significant benefits over existing solutions.
Alternative Embodiments and Variations
Alternative embodiments of this inventive concept could include the use of different detection methods, varying concentrations of crenolanib, or combinations with other therapeutic agents. Variations could also involve adapting the systems and methods for use in other industries or fields where FLT3 mutations are relevant.
Potential Commercial Applications and Market
This inventive concept has significant commercial potential in various industries, including industrial air quality control, agricultural fungicides, water treatment, veterinary therapeutics, and pest population management. The target market includes companies and organizations operating in these industries, as well as government agencies responsible for environmental regulation and public health.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Pharmaceutical biotechnology, specifically targeted molecular therapies for cellular mutations and kinase inhibition, with expertise in molecular targeting, drug repurposing, and mutation-specific therapeutic strategies
Person of Ordinary Skill (PHOSITA) Profile
A researcher or practitioner with advanced degrees in molecular biology, pharmacology, or biochemistry, possessing knowledge of tyrosine kinase inhibitors, mutation detection techniques, and interdisciplinary therapeutic applications
Obviousness Rationale
A PHOSITA would recognize that crenolanib's core mechanism of targeting FLT3 mutations provides a versatile platform for addressing similar molecular targeting challenges across multiple domains. The source patent establishes crenolanib's fundamental capability to interact with mutated cellular structures, which naturally suggests potential applications beyond oncological treatments. Given the patent's emphasis on FLT3 mutation detection and targeted intervention, extending this approach to other fields represents a logical and predictable technological progression.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,546 |
|---|---|
| Title | Crenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment |
| Assignee(s) | Arog Pharmaceuticals, Inc. |