Synergistic FLT3 Cancer Treatment System

Publication ID: 24-11857546_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic FLT3 Cancer Treatment System,” Published Technical Disclosure No. 24-11857546_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857546_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,546.

Summary of the Inventive Concept

A comprehensive system integrating crenolanib with AI, IoT, blockchain, and nanomaterials to treat FLT3 mutated proliferative disorders, enhancing treatment outcomes and patient monitoring.

Background and Problem Solved

The original patent disclosed the use of crenolanib for treating FLT3 mutated proliferative disorders. However, it lacked a comprehensive system for personalized treatment, real-time monitoring, and secure data storage. The new inventive concept addresses these limitations by integrating distinct technologies to create a more powerful system.

Detailed Description of the Inventive Concept

The system comprises a crenolanib administration module, a patient monitoring module utilizing artificial intelligence to predict treatment outcomes, and a blockchain-based data storage module to securely store patient data. Additionally, the system may include a genomics analysis module using next-generation sequencing to identify FLT3 mutations, an IoT-based patient monitoring system to track treatment efficacy, and a nanomaterial-based delivery system to enhance bioavailability and target FLT3-positive cancer cells.

Novelty and Inventive Step

The new inventive concept combines crenolanib with AI, IoT, blockchain, and nanomaterials to create a synergistic system, which is not obvious from the original patent. The integration of these distinct technologies provides a non-obvious solution to the problem of personalized FLT3 cancer treatment.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, IoT devices, blockchain platforms, or nanomaterials. Variations may include the integration of additional technologies, such as machine learning or gene editing, to further enhance treatment outcomes.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and biotechnology industries, particularly in the area of personalized cancer treatment. The system may be marketed to healthcare providers, pharmaceutical companies, and research institutions, offering a comprehensive solution for FLT3 cancer treatment.

Original Patent Information

Patent NumberUS 11,857,546
TitleCrenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment
Assignee(s)Arog Pharmaceuticals, Inc.