Crenolanib-Based Solutions for Niche Markets and Extreme Environments

Publication ID: 24-11857546_0004_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Crenolanib-Based Solutions for Niche Markets and Extreme Environments,” Published Technical Disclosure No. 24-11857546_0004_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857546_0004_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,546.

Summary of the Inventive Concept

The inventive concept adapts crenolanib-based treatments for FLT3 mutated proliferative disorders to address specific, narrow market needs and unique operational environments, such as disaster relief, extreme weather conditions, high-security settings, and areas with limited access to medical resources.

Background and Problem Solved

The original patent disclosed crenolanib-based treatments for FLT3 mutated proliferative disorders, but these treatments may not be suitable for niche markets or extreme environments. This inventive concept addresses the limitations of the original patent by providing specialized solutions for these specific contexts.

Detailed Description of the Inventive Concept

The inventive concept comprises four main areas of innovation: (1) a system for treating hematological malignancies in remote disaster relief areas, featuring a crenolanib-based pharmaceutical composition and a portable, solar-powered refrigeration unit; (2) a method for treating FLT3 mutated proliferative disorders in extreme weather conditions, utilizing a wind-resistant, waterproof shelter for administration; (3) a high-security, tamper-evident container for storing and transporting crenolanib-based pharmaceutical compositions in high-security environments; and (4) a method for treating hematological malignancies in areas with limited access to medical resources, leveraging a telemedicine platform for remote monitoring and consultation. Additionally, a portable, battery-powered diagnostic device for detecting FLT3 mutations in subjects suffering from hematological malignancies in disaster relief areas is disclosed.

Novelty and Inventive Step

The inventive concept's novelty lies in its adaptation of crenolanib-based treatments to specific, narrow market needs and unique operational environments, which is non-obvious compared to the original patent. The inventive step is the combination of crenolanib-based pharmaceutical compositions with specialized equipment, infrastructure, and logistical solutions tailored to these niche contexts.

Alternative Embodiments and Variations

Alternative embodiments may include modifications to the portable refrigeration unit, wind-resistant shelter, or high-security container to accommodate different environmental conditions or security requirements. Variations may also involve integrating the crenolanib-based treatment with other diagnostic tools or telemedicine platforms to enhance patient care.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in niche markets, such as disaster relief, extreme weather conditions, high-security settings, and areas with limited access to medical resources. Target industries include pharmaceutical companies, medical device manufacturers, and telemedicine service providers.

Original Patent Information

Patent NumberUS 11,857,546
TitleCrenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment
Assignee(s)Arog Pharmaceuticals, Inc.