Synergistic FLT3 Mutated Proliferative Disorder Treatment System

Publication ID: 24-11857546_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic FLT3 Mutated Proliferative Disorder Treatment System,” Published Technical Disclosure No. 24-11857546_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857546_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,546.

Summary of the Inventive Concept

The present inventive concept integrates crenolanib with AI, IoT, blockchain, and new materials to create a more effective and personalized treatment system for FLT3 mutated proliferative disorders.

Background and Problem Solved

The original patent disclosed the use of crenolanib for treating FLT3 mutated proliferative disorders, but its efficacy was limited by the lack of personalized treatment regimens, inefficient patient data management, and inadequate disease progression monitoring. The new inventive concept addresses these limitations by incorporating distinct technologies to create a more powerful system.

Detailed Description of the Inventive Concept

The new system comprises a crenolanib administration module, an AI-powered disease progression monitoring module, and a blockchain-based patient data management module. This integration enables personalized treatment regimens, real-time monitoring, and secure data management. Additionally, IoT-enabled sensors track patient response, and AI-driven analytics predict optimal dosing and treatment schedules. The composition incorporates nanoparticle-based delivery systems using new materials such as graphene, nanocellulose, or nanostructured lipid carriers, enhancing crenolanib's efficacy and bioavailability.

Novelty and Inventive Step

The new inventive concept is novel and non-obvious because it combines crenolanib with distinct technologies, creating a synergistic system that overcomes the limitations of the original patent. The integration of AI, IoT, blockchain, and new materials provides a unique solution for FLT3 mutated proliferative disorder treatment.

Alternative Embodiments and Variations

Alternative embodiments may include variations in the AI-powered disease progression monitoring module, such as using machine learning algorithms or natural language processing. Other variations may include different nanoparticle-based delivery systems or the incorporation of additional distinct technologies, such as gene editing or immunotherapy.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the treatment of FLT3 mutated proliferative disorders. The system's ability to provide personalized treatment regimens, real-time monitoring, and secure data management addresses a significant unmet need in the market.

Original Patent Information

Patent NumberUS 11,857,546
TitleCrenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment
Assignee(s)Arog Pharmaceuticals, Inc.