Crenolanib-based Solutions for Specialized Treatment Environments

Publication ID: 24-11857546_0009_PTD
Published: October 28, 2025
Category:Specialized Variations & Niche Solutions

Legal Citation

pr1or.art Inc., “Crenolanib-based Solutions for Specialized Treatment Environments,” Published Technical Disclosure No. 24-11857546_0009_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857546_0009_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,546.

Summary of the Inventive Concept

The present invention provides novel crenolanib-based systems, methods, and compositions tailored for treating FLT3 mutated proliferative disorders in high-security facilities, disaster relief settings, extreme weather conditions, remote or isolated locations, and areas with limited access to medical facilities.

Background and Problem Solved

The original patent disclosed the use of crenolanib for treating FLT3 mutated proliferative disorders. However, the existing solutions do not adequately address the unique challenges and constraints of specialized treatment environments. The present inventive concept addresses these limitations by providing targeted solutions for specific operational environments, ensuring effective treatment and improved patient outcomes.

Detailed Description of the Inventive Concept

The inventive concept encompasses a range of novel systems, methods, and compositions that adapt crenolanib-based treatment to distinct operational environments. For instance, the system for high-security facilities features a secure storage unit, dispensing unit, and monitoring unit to ensure controlled and monitored treatment. The method for disaster relief settings involves administering crenolanib through a portable, self-contained treatment unit. The composition for extreme weather conditions incorporates weather-resistant packaging to protect the formulation from environmental degradation. The kit for remote or isolated locations includes instructional materials and a container holding a therapeutically effective amount of crenolanib. The system for areas with limited access to medical facilities leverages telemedicine and remote dispensing units to facilitate treatment.

Novelty and Inventive Step

The inventive concept's novelty lies in its tailored approach to addressing the specific challenges of specialized treatment environments. The new claims introduce non-obvious features, such as secure storage units, portable treatment units, weather-resistant packaging, and remote dispensing units, which differentiate the inventive concept from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include modifying the dispensing unit for high-security facilities to accommodate varying levels of security clearance. Variations of the method for disaster relief settings could involve integrating the portable treatment unit with existing emergency response systems. Other embodiments might focus on adapting the composition for extreme weather conditions to specific environmental stressors, such as high temperatures or humidity.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the pharmaceutical and healthcare industries, particularly in the areas of oncology and rare disease treatment. Target markets include government agencies, disaster relief organizations, and healthcare providers operating in specialized environments. The inventive concept's tailored solutions can improve patient outcomes, reduce treatment costs, and enhance the overall efficiency of healthcare services in these unique settings.

Field of Art

Pharmaceutical oncology, specifically targeted cancer therapies for hematological malignancies with a focus on FLT3 tyrosine kinase inhibitors and treatment delivery systems

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical researcher or clinical oncologist with expertise in targeted cancer therapies, molecular diagnostics, drug delivery systems, and experience with developing treatment protocols for specialized medical environments

Obviousness Rationale

A person having ordinary skill in the art would recognize that the PTD represents predictable variations of the source patent's core invention by adapting the crenolanib treatment methodology to specific operational contexts. The fundamental therapeutic approach remains consistent, with the PTD merely extending the treatment paradigm through logical environmental and logistical modifications. These variations represent standard design adaptations that would be apparent to a skilled practitioner seeking to optimize drug delivery across diverse medical scenarios.

Obvious Combinations & Variations

Source Patent Element
Method for treating FLT3 mutated proliferative disorders using crenolanib
PTD Variation
Specialized treatment systems for high-security facilities, disaster relief, extreme weather, remote locations
Obviousness Reasoning
Adapting drug delivery to specific environments represents a predictable design variation using known pharmaceutical engineering techniques, with no unexpected results
Source Patent Element
Therapeutically effective dosage ranges of 50-500 mg per day
PTD Variation
Portable self-contained treatment units with integrated dosage management
Obviousness Reasoning
Implementing controlled drug delivery mechanisms is a standard engineering solution for maintaining consistent therapeutic dosing across varied environments
Source Patent Element
Treatment of hematological malignancies with FLT3 mutations
PTD Variation
Telemedicine and remote monitoring systems for treatment administration
Obviousness Reasoning
Integrating digital health technologies with established pharmaceutical protocols represents an obvious technological progression for improving patient care and treatment accessibility
Source Patent Element
Pharmaceutical composition for cancer treatment
PTD Variation
Weather-resistant packaging to protect drug formulation
Obviousness Reasoning
Developing protective packaging for pharmaceutical compounds is a routine engineering task with predictable solutions based on known material science principles
Source Patent Element
Method of administering tyrosine kinase inhibitors
PTD Variation
Secure storage and dispensing units with monitoring capabilities
Obviousness Reasoning
Creating controlled distribution systems for specialized medical treatments represents a standard approach to managing high-security or sensitive pharmaceutical interventions
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857546, the present publication demonstrates that the claimed variations in treatment delivery systems for crenolanib represent obvious extensions of the prior art, employing standard pharmaceutical engineering techniques to adapt the core therapeutic methodology to diverse operational environments. A person having ordinary skill in the art would find the disclosed variations to be predictable modifications that do not rise to the level of non-obvious innovation required for patent protection.

Original Patent Information

Patent NumberUS 11,857,546
TitleCrenolanib for treating FLT3 mutated proliferative disorders relapsed/refractory to prior treatment
Assignee(s)Arog Pharmaceuticals, Inc.