Diversified Applications of Hydrocortisone Sodium Phosphate and Monothioglycerol Formulations

Publication ID: 24-11857555_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Diversified Applications of Hydrocortisone Sodium Phosphate and Monothioglycerol Formulations,” Published Technical Disclosure No. 24-11857555_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857555_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,555.

Summary of the Inventive Concept

The inventive concept leverages the core technology of the original patent to expand into new industries, including agriculture, food preservation, cosmetics, textiles, and water purification, by utilizing the unique properties of hydrocortisone sodium phosphate and monothioglycerol formulations.

Background and Problem Solved

The original patent focused on the development of an aqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol for human therapeutic use. However, the formulation's potential applications extend far beyond pharmaceuticals. The inventive concept addresses the limitations of the original patent by exploring new industries and use cases that can benefit from the unique properties of these formulations.

Detailed Description of the Inventive Concept

The new claims describe the application of hydrocortisone sodium phosphate and monothioglycerol formulations in various industries. For instance, the formulation can be used in agriculture to enhance soil fertility and reduce soil erosion, in food preservation as a natural antimicrobial agent, in cosmetics to reduce skin inflammation and promote skin hydration, in textiles to improve fabric softness and durability, and in water purification to remove impurities and contaminants. The formulations' unique properties, such as their ability to reduce inflammation and promote hydration, make them ideal for these new applications.

Novelty and Inventive Step

The new claims introduce a significant inventive step by applying the core technology of the original patent to entirely new industries and use cases, which were not originally considered. The novelty of the inventive concept lies in the unexpected application of hydrocortisone sodium phosphate and monothioglycerol formulations in these new areas, which provides a unique solution to specific problems in each industry.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include varying the concentration of hydrocortisone sodium phosphate and monothioglycerol, adding additional ingredients to enhance the formulations' properties, or modifying the manufacturing process to improve scalability and cost-effectiveness. These variations could further expand the potential applications of the inventive concept across different industries.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential across various industries, including agriculture, food preservation, cosmetics, textiles, and water purification. The market for these applications is substantial, with potential customers including farmers, food manufacturers, cosmetic companies, textile producers, and water treatment facilities. The inventive concept's unique value proposition lies in its ability to provide sustainable, effective, and natural solutions to specific problems in each industry, making it an attractive option for companies looking to innovate and differentiate themselves.

Field of Art

Pharmaceutical formulations, specifically aqueous compositions with active pharmaceutical ingredients and stabilizing agents, with expertise in chemical engineering, pharmaceutical chemistry, and biotechnology

Person of Ordinary Skill (PHOSITA) Profile

A professional with advanced degree (MS/PhD) in pharmaceutical sciences or chemical engineering, 3-5 years industrial experience in drug formulation, familiar with pharmaceutical excipients, stability testing, and cross-industry applications of chemical compounds

Obviousness Rationale

A PHOSITA would recognize that the unique properties of hydrocortisone sodium phosphate and monothioglycerol - specifically their anti-inflammatory, stabilizing, and interaction characteristics - naturally suggest broader applications beyond pharmaceutical contexts. The formulation's core chemical attributes inherently enable versatile uses across multiple industries by leveraging known properties of its constituent compounds. The disclosed variations represent predictable extensions of the original patent's fundamental technological insights.

Obvious Combinations & Variations

Source Patent Element
Aqueous pharmaceutical formulation with hydrocortisone sodium phosphate and monothioglycerol
PTD Variation
Agricultural soil treatment application
Obviousness Reasoning
Known anti-inflammatory properties suggest potential soil interaction and nutrient modulation, representing a predictable technological transfer between domains
Source Patent Element
Stabilizing pharmaceutical composition with antimicrobial components
PTD Variation
Food preservation antimicrobial application
Obviousness Reasoning
Monothioglycerol's inherent preservation characteristics make cross-domain antimicrobial use an obvious technical adaptation
Source Patent Element
Hydrocortisone's skin interaction mechanisms
PTD Variation
Cosmetic inflammation reduction and skin hydration
Obviousness Reasoning
Well-established dermatological properties of hydrocortisone make cosmetic applications a straightforward, predictable extension
Source Patent Element
Chemical formulation with surface interaction capabilities
PTD Variation
Textile treatment for softness and durability
Obviousness Reasoning
Molecular properties suggesting surface modification represent a known technique for enhancing material characteristics
Source Patent Element
Aqueous pharmaceutical composition with purification potential
PTD Variation
Water purification contaminant removal
Obviousness Reasoning
Inherent chemical interaction and binding properties suggest obvious application in filtration and purification contexts
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed herein would have been obvious to a person of ordinary skill in the art at the time of invention, based on the teachings of US Patent 11857555. The published technical disclosure demonstrates that the claimed innovations represent predictable technological extensions employing known techniques, chemical interactions, and domain-transferable properties, thus rendering subsequent claims obvious and anticipatable as a matter of law.

Original Patent Information

Patent NumberUS 11,857,555
TitleAqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol
Assignee(s)Antares Pharma, Inc.