Synergistic Hydrocortisone Sodium Phosphate Combinations for Enhanced Therapeutic Outcomes

Publication ID: 24-11857555_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Hydrocortisone Sodium Phosphate Combinations for Enhanced Therapeutic Outcomes,” Published Technical Disclosure No. 24-11857555_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857555_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,555.

Summary of the Inventive Concept

This inventive concept integrates hydrocortisone sodium phosphate with cutting-edge technologies like AI, IoT, blockchain, and novel materials to create powerful systems for personalized medicine, co-administration, wearable devices, implants, and predictive dosing regimens, enhancing therapeutic outcomes for allergic reactions and inflammatory skin conditions.

Background and Problem Solved

The original patent disclosed an aqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol. However, it lacked the integration with distinct technologies to create more powerful systems. This inventive concept addresses the limitation by combining the formulation with AI, IoT, blockchain, and novel materials to provide more effective and personalized treatments.

Detailed Description of the Inventive Concept

The synergistic combinations comprise a hydrocortisone sodium phosphate aqueous pharmaceutical formulation integrated with AI-driven dosing algorithms for customized treatment, blockchain-secured supply chain management systems for ensuring authenticity and trackability, IoT-enabled sensors for real-time monitoring of skin conditions, micro-needling systems for enhanced drug delivery, biocompatible polymer matrices for implantable devices, and machine learning algorithms for predicting optimal dosing regimens. These combinations enable personalized medicine, co-administration, wearable devices, implants, and predictive dosing regimens.

Novelty and Inventive Step

The novelty of this inventive concept lies in the integration of the hydrocortisone sodium phosphate formulation with distinct technologies, creating powerful systems that were not obvious from the original patent. The inventive step is the recognition of the potential of these synergistic combinations to enhance therapeutic outcomes.

Alternative Embodiments and Variations

Alternative embodiments may include varying the AI-driven dosing algorithms, blockchain protocols, IoT sensor configurations, and novel material compositions to accommodate different patient populations, disease states, or treatment regimens. Variations may also involve integrating additional technologies, such as nanotechnology or gene editing, to further enhance the therapeutic outcomes.

Potential Commercial Applications and Market

The synergistic combinations have significant commercial potential in the pharmaceutical, biotechnology, and healthcare industries, particularly in the areas of personalized medicine, dermatology, and immunology. The market demand for more effective and personalized treatments for allergic reactions and inflammatory skin conditions is substantial, and these combinations are poised to capture a significant share of this market.

Original Patent Information

Patent NumberUS 11,857,555
TitleAqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol
Assignee(s)Antares Pharma, Inc.