Synergistic Hydrocortisone Sodium Phosphate Combinations for Enhanced Therapeutic Outcomes

Publication ID: 24-11857555_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic Hydrocortisone Sodium Phosphate Combinations for Enhanced Therapeutic Outcomes,” Published Technical Disclosure No. 24-11857555_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857555_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,555.

Summary of the Inventive Concept

This inventive concept integrates hydrocortisone sodium phosphate with cutting-edge technologies like AI, IoT, blockchain, and novel materials to create powerful systems for personalized medicine, co-administration, wearable devices, implants, and predictive dosing regimens, enhancing therapeutic outcomes for allergic reactions and inflammatory skin conditions.

Background and Problem Solved

The original patent disclosed an aqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol. However, it lacked the integration with distinct technologies to create more powerful systems. This inventive concept addresses the limitation by combining the formulation with AI, IoT, blockchain, and novel materials to provide more effective and personalized treatments.

Detailed Description of the Inventive Concept

The synergistic combinations comprise a hydrocortisone sodium phosphate aqueous pharmaceutical formulation integrated with AI-driven dosing algorithms for customized treatment, blockchain-secured supply chain management systems for ensuring authenticity and trackability, IoT-enabled sensors for real-time monitoring of skin conditions, micro-needling systems for enhanced drug delivery, biocompatible polymer matrices for implantable devices, and machine learning algorithms for predicting optimal dosing regimens. These combinations enable personalized medicine, co-administration, wearable devices, implants, and predictive dosing regimens.

Novelty and Inventive Step

The novelty of this inventive concept lies in the integration of the hydrocortisone sodium phosphate formulation with distinct technologies, creating powerful systems that were not obvious from the original patent. The inventive step is the recognition of the potential of these synergistic combinations to enhance therapeutic outcomes.

Alternative Embodiments and Variations

Alternative embodiments may include varying the AI-driven dosing algorithms, blockchain protocols, IoT sensor configurations, and novel material compositions to accommodate different patient populations, disease states, or treatment regimens. Variations may also involve integrating additional technologies, such as nanotechnology or gene editing, to further enhance the therapeutic outcomes.

Potential Commercial Applications and Market

The synergistic combinations have significant commercial potential in the pharmaceutical, biotechnology, and healthcare industries, particularly in the areas of personalized medicine, dermatology, and immunology. The market demand for more effective and personalized treatments for allergic reactions and inflammatory skin conditions is substantial, and these combinations are poised to capture a significant share of this market.

Field of Art

Pharmaceutical formulations, specifically aqueous pharmaceutical compositions for corticosteroid delivery, with expertise in drug formulation, pharmaceutical engineering, and advanced drug delivery technologies

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical scientist or chemical engineer with advanced degree, experience in drug formulation, knowledge of pharmaceutical technologies, understanding of drug delivery systems, and familiarity with emerging medical technologies

Obviousness Rationale

A PHOSITA would recognize that integrating digital technologies with pharmaceutical formulations is a predictable extension of modern pharmaceutical research. The source patent's hydrocortisone sodium phosphate formulation provides a foundational composition that naturally invites technological enhancement for improved patient outcomes. The PTD's proposed variations represent logical technological progressions using well-established techniques in personalized medicine and digital health monitoring.

Obvious Combinations & Variations

Source Patent Element
Aqueous pharmaceutical formulation of hydrocortisone sodium phosphate with specific concentration ranges
PTD Variation
AI-driven dosing algorithms for customized treatment using the same hydrocortisone sodium phosphate formulation
Obviousness Reasoning
Personalized dosing is a known technique in pharmaceutical research, and applying machine learning to optimize drug delivery represents a predictable application of existing computational technologies
Source Patent Element
Pharmaceutical composition with monothioglycerol
PTD Variation
Blockchain-secured supply chain management for tracking pharmaceutical product authenticity
Obviousness Reasoning
Supply chain tracking is a standard practice in pharmaceutical distribution, and blockchain represents a known technological solution for ensuring product integrity and traceability
Source Patent Element
Hydrocortisone sodium phosphate for treating inflammatory conditions
PTD Variation
IoT-enabled sensors for real-time monitoring of skin conditions with transdermal delivery systems
Obviousness Reasoning
Remote patient monitoring and enhanced drug delivery are well-established trends in medical technology, representing a logical extension of existing pharmaceutical research
Source Patent Element
Aqueous pharmaceutical formulation with specific chemical composition
PTD Variation
Biocompatible polymer matrices and hydrogel-based delivery systems for sustained drug release
Obviousness Reasoning
Advanced drug delivery systems using polymers and hydrogels are known techniques in pharmaceutical engineering for improving drug absorption and patient compliance
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857555 and the published technical disclosure, a person having ordinary skill in the art would find the proposed technological variations obvious and predictable extensions of existing pharmaceutical formulation and delivery technologies. The integration of digital monitoring, personalized dosing, and advanced delivery mechanisms represents a logical progression that would be apparent to a skilled practitioner in pharmaceutical engineering and digital health technologies.

Original Patent Information

Patent NumberUS 11,857,555
TitleAqueous pharmaceutical formulation of hydrocortisone sodium phosphate and monothioglycerol
Assignee(s)Antares Pharma, Inc.