Self-Healing Bioactive Dental Compositions
Legal Citation
Summary of the Inventive Concept
Next-generation dental and medical compositions featuring multiparticulate crystalline multimetallic silicates with self-healing capabilities, designed to stimulate tissue regeneration and promote remineralization of tooth enamel.
Background and Problem Solved
The original patent introduced bioceramic compositions for endodonic applications, but these compositions had limitations in terms of their ability to stimulate tissue regeneration and promote remineralization. The new inventive concept addresses these limitations by incorporating self-healing capabilities and controlled release of metallic ions, enabling more effective treatment of dental caries and bone tissue engineering.
Detailed Description of the Inventive Concept
The new inventive concept comprises a multiparticulate crystalline multimetallic silicate with a self-healing capability, which is designed to release metallic ions at a predetermined rate to stimulate tissue regeneration. The composition can be formulated as a powder phase and an aqueous liquid carrier, and may incorporate additional components such as biodegradable polymers and bioactive glasses. The self-healing capability is achieved through the controlled release of calcium ions, which promotes remineralization of tooth enamel and bone regeneration. The composition can be delivered to a dental cavity using a syringe-based applicator and a removable tip, ensuring precise control over the amount of composition released.
Novelty and Inventive Step
The new claims introduce the concept of self-healing capabilities and controlled release of metallic ions, which is a significant departure from the original patent's composition. The use of multiparticulate crystalline multimetallic silicates with self-healing capabilities is novel and non-obvious, and provides a significant improvement over existing dental and medical compositions.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include variations in the type and amount of metallic ions released, the formulation of the composition, and the method of delivery. For example, the composition could be formulated as a paste or gel, or could be delivered using a different type of applicator. Additionally, the composition could be adapted for use in bone tissue engineering or other medical applications.
Potential Commercial Applications and Market
The new inventive concept has significant commercial potential in the dental and medical industries, particularly in the areas of dental caries treatment and bone tissue engineering. The composition's self-healing capabilities and controlled release of metallic ions make it an attractive solution for clinicians and researchers looking for more effective and sustainable treatments.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Dental and medical biomaterials, specifically bioceramic compositions for dental restoration and tissue regeneration, with expertise in materials science, inorganic chemistry, and biomedical engineering
Person of Ordinary Skill (PHOSITA) Profile
A professional with advanced degree (MS/PhD) in materials science or biomedical engineering, experienced in developing dental and medical compositions, familiar with metallic ion-based regenerative materials, and skilled in understanding material interactions and controlled release mechanisms
Obviousness Rationale
A PHOSITA would recognize that the PTD's self-healing and controlled release variations are logical extensions of the source patent's multiparticulate crystalline multimetallic silicate composition. The fundamental structural and compositional elements are substantially similar, with the PTD introducing predictable enhancements in ion release and tissue regeneration strategies. The modifications represent incremental improvements using known techniques in biomaterial design, which would be obvious to a skilled practitioner seeking to optimize dental restoration materials.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,558 |
|---|---|
| Title | Dental and medical compositions having a multiple source of metallic ions |
| Assignee(s) | ANGELUS INDUSTRIA DE PRODUTOS ODONTOLOGICOS S/A |