Novel Applications of Sulfur-Containing Nucleotides in Agriculture, Aquaculture, Cosmetics, and Diagnostics

Publication ID: 24-11857560_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Novel Applications of Sulfur-Containing Nucleotides in Agriculture, Aquaculture, Cosmetics, and Diagnostics,” Published Technical Disclosure No. 24-11857560_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857560_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,560.

Summary of the Inventive Concept

This inventive concept discloses novel applications of sulfur-containing nucleotides and nucleosides, originally developed for treating viral infections, in entirely new industries and fields, including agricultural pest control, treatment of fungal diseases in aquatic organisms, cosmetic compositions for skin care, diagnostic kits for detecting viral infections in animals, and treatment of bacterial infections in food products.

Background and Problem Solved

The original patent disclosed sulfur-containing nucleotides and nucleosides for treating viral infections. However, the patent's scope was limited to pharmaceutical compositions for human viral infections. This inventive concept addresses the need for innovative solutions in other industries, where the unique properties of sulfur-containing nucleotides and nucleosides can be leveraged to provide effective and targeted solutions.

Detailed Description of the Inventive Concept

The inventive concept comprises novel applications of sulfur-containing nucleotides and nucleosides in various industries. In agricultural pest control, these compositions can be used to target fungal infections in plants. In aquaculture, they can be used to treat fungal diseases in aquatic organisms. In cosmetics, they can be used to reduce skin inflammation. In diagnostics, they can be used to detect viral infections in animals. In food products, they can be used to treat bacterial infections. The sulfur-containing base is effective against a range of microorganisms, making it a versatile solution for various industries.

Novelty and Inventive Step

The novelty of this inventive concept lies in the application of sulfur-containing nucleotides and nucleosides to entirely new industries and fields, which was not originally considered in the original patent. The inventive step is the recognition of the potential of these compositions to provide effective solutions in these new areas, and the development of new claims that capture this expanded scope.

Alternative Embodiments and Variations

Alternative embodiments of this inventive concept could include the use of different sulfur-containing bases, different conjugate compounds, or different formulations for specific industries. Variations could include the use of these compositions in combination with other compounds or treatments, or the development of new methods for administering these compositions.

Potential Commercial Applications and Market

This inventive concept has significant commercial potential in various industries, including agriculture, aquaculture, cosmetics, diagnostics, and food products. The market for these applications is substantial, with a growing need for innovative solutions to address specific problems in each industry.

Field of Art

Pharmaceutical chemistry, specifically nucleotide and nucleoside composition design with applications in biotechnology, medical, and agricultural domains

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degree in pharmaceutical chemistry or molecular biology, experienced in nucleotide modification, conjugation techniques, and interdisciplinary application of molecular compounds

Obviousness Rationale

A PHOSITA would recognize the inherent versatility of sulfur-containing nucleotides based on their broad molecular interactions and potential for cross-industry applications. The source patent's comprehensive description of nucleotide compositions provides a clear framework for exploring alternative uses beyond viral treatment. The structural flexibility and demonstrated biological activity of these compounds would naturally suggest potential applications in adjacent fields like agriculture, diagnostics, and cosmetics.

Obvious Combinations & Variations

Source Patent Element
Sulfur-containing nucleosides with phosphorus oxide conjugation
PTD Variation
Agricultural pest control application targeting fungal infections in plants
Obviousness Reasoning
Known antimicrobial properties of sulfur-containing nucleotides make agricultural fungal treatment a predictable extension of existing molecular design
Source Patent Element
Pharmaceutical composition with excipients like glucose and starch
PTD Variation
Cosmetic formulations for skin inflammation reduction
Obviousness Reasoning
Established pharmaceutical compounding techniques directly translate to cosmetic product development, representing a routine design modification
Source Patent Element
Nucleotide compositions with potential viral interaction mechanisms
PTD Variation
Diagnostic kit for detecting RNA-dependent RNA polymerase activity
Obviousness Reasoning
Molecular recognition principles underlying viral detection are consistent with the source patent's core technological framework
Source Patent Element
Conjugate compounds involving phosphorus oxide linkages
PTD Variation
Aquaculture treatment for fungal diseases in aquatic organisms
Obviousness Reasoning
Broad-spectrum antimicrobial potential suggests predictable efficacy across different biological environments
Source Patent Element
Pharmaceutical compositions with diverse base modifications
PTD Variation
Bacterial infection treatment in food products
Obviousness Reasoning
Generalized antimicrobial mechanism implies straightforward adaptation to different infection contexts
35 U.S.C. § 103 Summary: Based on the comprehensive disclosure of US Patent 11857560, a person having ordinary skill in the art would find the variations disclosed herein to be obvious extensions of the existing nucleotide composition technology. The structural similarities, established molecular interaction principles, and demonstrated versatility of sulfur-containing nucleotides render the proposed alternative applications predictable and non-inventive under standard obviousness analysis.

Original Patent Information

Patent NumberUS 11,857,560
TitlePharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
Assignee(s)Emory University