Nucleotide-based Pathogen Treatment Systems for Water, Agriculture, and Surfaces

This inventive concept expands the application of nucleotide and nucleoside compositions to treat waterborne pathogens, agricultural pathogens, and surface pathogens, leveraging the core technology of the original patent to address critical problems in these new fields.

The original patent disclosed pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections. However, the growing concern about waterborne, agricultural, and surface pathogens necessitates innovative solutions. The new inventive concept addresses these pressing issues by adapting the core technology to develop nucleotide-based treatment systems for these new applications.

The inventive concept involves the use of nucleotide or nucleoside compositions of Formula Im, wherein R1 is:, R2 is alkyl or cycloalkyl, and R3 is aryl, wherein the aryl is optionally substituted with one or more substituents. These compositions can be applied to water treatment systems to reduce the concentration of waterborne pathogens, to crops to reduce the concentration of agricultural pathogens, or to surfaces to reduce the concentration of pathogens. The compositions can be prepared using various methods, including conjugation with amino acid esters, lipids, or sphingolipids, and can be formulated with pharmaceutically acceptable excipients.

The new claims introduce a novel application of the nucleotide and nucleoside compositions, extending their use beyond pharmaceutical compositions for treating viral infections to treating waterborne, agricultural, and surface pathogens. The inventive step lies in the recognition of the potential of these compositions to address critical problems in these new fields and the adaptation of the core technology to develop effective treatment systems.

Alternative embodiments of the inventive concept could include the use of different nucleotide or nucleoside compositions, varying the type and amount of substituents, or modifying the formulation to enhance efficacy or stability. Additionally, the treatment systems could be integrated with existing infrastructure, such as water treatment plants or agricultural irrigation systems, to enhance their effectiveness.

The inventive concept has significant commercial potential in the water treatment, agriculture, and surface disinfection industries, where the need for effective pathogen treatment solutions is pressing. The market for these solutions is substantial, with potential applications in municipal water treatment, agricultural crop protection, and surface disinfection for healthcare and food processing facilities.