Intelligent Autoimmune Disease Prevention and Treatment System

Publication ID: 24-11857563_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Intelligent Autoimmune Disease Prevention and Treatment System,” Published Technical Disclosure No. 24-11857563_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857563_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,563.

Summary of the Inventive Concept

A synergistic system integrating AI, IoT, blockchain, and nanomaterials to diagnose, predict, and treat autoimmune diseases by targeting pathogenic age-associated B cells, providing personalized medicine and improving treatment outcomes.

Background and Problem Solved

The original patent addressed the limitations of current autoimmune disease treatments by targeting pathogenic age-associated B cells. However, it lacked a comprehensive approach to diagnose, predict, and treat autoimmune diseases. This new inventive concept addresses these limitations by integrating distinct technologies to provide a more effective and personalized solution.

Detailed Description of the Inventive Concept

The system consists of a machine learning module trained on a dataset of pathogenic age-associated B cell characteristics, a blockchain-based data storage module for secure storage of patient data, and IoT-enabled wearable devices for monitoring patient health metrics. The AI-powered personalized medicine analyzes the health metrics and provides treatment recommendations. The system also includes a nanomaterial-based delivery system for targeted delivery of nucleic acids encoding human DEF6 protein and human SWAP-70 protein to pathogenic age-associated B cells. Additionally, the system features an AI-powered diagnostic module for real-time monitoring of treatment efficacy and a blockchain-based simulation platform for validating novel therapeutic targets.

Novelty and Inventive Step

The new claims introduce a synergistic combination of AI, IoT, blockchain, and nanomaterials, which is novel and non-obvious compared to the original patent. The integration of these distinct technologies provides a more comprehensive and effective solution for autoimmune disease diagnosis, prediction, and treatment.

Alternative Embodiments and Variations

Alternative embodiments include using different machine learning algorithms, varying the type of IoT-enabled devices, or incorporating additional technologies such as robotics or 3D printing. Variations of the system could be tailored to specific autoimmune diseases or patient populations, further expanding its applicability.

Potential Commercial Applications and Market

The Intelligent Autoimmune Disease Prevention and Treatment System has significant commercial potential in the healthcare industry, particularly in the fields of personalized medicine, precision health, and digital therapeutics. The system could be marketed to pharmaceutical companies, healthcare providers, and medical research institutions, offering a competitive advantage in autoimmune disease diagnosis and treatment.

Original Patent Information

Patent NumberUS 11,857,563
TitleInhibition of expansion and function of pathogenic age-associated B cells and use for the prevention and treatment of autoimmune disease
Assignee(s)NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY