Synergistic Combinations for Autoimmune Disease Prevention and Treatment
Legal Citation
Summary of the Inventive Concept
The inventive concept integrates the original patented method for targeting pathogenic age-associated B cells with distinct technologies such as AI, IoT, blockchain, and new materials to create a more powerful system for diagnosing, preventing, and treating autoimmune diseases.
Background and Problem Solved
The original patent provides a method for treating autoimmune diseases by targeting pathogenic age-associated B cells. However, the patent has limitations in terms of diagnosis, prevention, and treatment. The new inventive concept addresses these limitations by combining the original method with advanced technologies to create a more comprehensive and effective system.
Detailed Description of the Inventive Concept
The inventive concept comprises five synergistic combinations: 1) a machine learning model and blockchain-based secure data storage system for diagnosing autoimmune diseases, 2) a method for preventing autoimmune disease using IoT-enabled wearable devices, 3) a nanoparticle-based delivery system and graphene-based sensor for treating lymphoproliferative disorders, 4) a deep learning model and cloud-based computing platform for predicting autoimmune disease risk, and 5) a natural language processing-based AI system and CRISPR-Cas9-based gene editing system for identifying novel therapeutic targets.
Novelty and Inventive Step
The new claims introduce novel combinations of the original patented method with advanced technologies, providing a more comprehensive and effective system for diagnosing, preventing, and treating autoimmune diseases. The inventive step lies in the unexpected integration of these distinct technologies to create a synergistic system that overcomes the limitations of the original patent.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include using different machine learning models, blockchain platforms, or IoT devices. Variations could include applying the system to different autoimmune diseases or using different nanoparticle-based delivery systems.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the healthcare industry, particularly in the fields of autoimmune disease diagnosis, prevention, and treatment. The market for autoimmune disease treatments is projected to grow significantly in the coming years, and the inventive concept is well-positioned to capitalize on this trend.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical engineering and immunology, with expertise in autoimmune disease diagnostics, genetic therapies, and advanced computational methods for medical research
Person of Ordinary Skill (PHOSITA) Profile
A researcher or medical technologist with advanced degrees in biomedical sciences, proficient in molecular biology techniques, machine learning, genomic analysis, and biotechnology innovation
Obviousness Rationale
A PHOSITA would recognize that integrating computational technologies with the source patent's genetic targeting method represents a natural progression in personalized medical research. The combination of machine learning, blockchain, and IoT technologies with genetic therapies is a predictable extension of existing biomedical research strategies. The PTD's variations demonstrate standard technological convergence in precision medicine approaches.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,563 |
|---|---|
| Title | Inhibition of expansion and function of pathogenic age-associated B cells and use for the prevention and treatment of autoimmune disease |
| Assignee(s) | NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY |