Next-Generation Hemostatic Compositions and Systems
Legal Citation
Summary of the Inventive Concept
This inventive concept envisions a paradigm shift in hemostatic compositions and systems, integrating advanced materials, personalized medicine, and wearable technologies to revolutionize bleeding control and management.
Background and Problem Solved
The original patent disclosed hemostatic compositions comprising an anion exchanger and a calcium salt. However, these compositions have limitations in terms of efficacy, specificity, and user convenience. The new inventive concept addresses these limitations by introducing nanofibrous matrices, personalized formulations, wearable devices, and targeted delivery mechanisms.
Detailed Description of the Inventive Concept
The next-generation hemostatic compositions and systems comprise nanofibrous matrices incorporating an anion exchanger and a calcium salt, which can self-assemble into hierarchical structures. Additionally, the concept includes personalized formulations tailored to individual bleeding profiles, wearable devices with sensors for detecting bleeding, and targeted delivery mechanisms using conjugated targeting moieties. These advancements enable enhanced hemostatic efficacy, improved user experience, and expanded applications in various medical fields.
Novelty and Inventive Step
The new claims introduce a significant inventive step by integrating advanced materials, personalized medicine, and wearable technologies, which are not obvious from the original patent. The use of nanofibrous matrices, conjugated targeting moieties, and wearable devices with sensors for detecting bleeding are novel and non-obvious features that distinguish the new inventive concept from the original patent.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different types of nanofibrous matrices, various targeting moieties, or alternative wearable device designs. Additionally, the concept could be adapted for use in veterinary medicine or in combination with other therapeutic agents.
Potential Commercial Applications and Market
The next-generation hemostatic compositions and systems have significant commercial potential in the medical device and pharmaceutical industries, with potential applications in trauma care, surgical settings, and emergency response situations. The market for these innovative products is expected to be substantial, driven by the growing need for effective bleeding control and management solutions.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biomedical engineering and hemostatic composition design, focusing on materials science, polymer chemistry, and medical device technologies with expertise in anion exchange materials and blood interaction mechanisms
Person of Ordinary Skill (PHOSITA) Profile
A researcher or engineer with advanced degrees in biomedical engineering or materials science, possessing knowledge of polymer chemistry, medical device design, and hemostatic material development, with understanding of ion exchange principles and blood interaction mechanisms
Obviousness Rationale
A person having ordinary skill in the art would recognize that the published technical disclosure represents predictable variations and extensions of the source patent's core hemostatic composition technology. The PTD's claims leverage known materials science techniques and design principles to enhance the original hemostatic composition concept. The modifications represent incremental improvements using standard engineering approaches within the established technological framework of the source patent.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,564 |
|---|---|
| Title | Hemostatic composition comprising an anion exchanger and a calcium salt |
| Assignee(s) | Omrix Biopharmaceuticals Ltd. |