Advanced Ozonized Olive Oil Formulations for Enhanced Vulvovaginitis Treatment

Publication ID: 24-11857570_0010_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Advanced Ozonized Olive Oil Formulations for Enhanced Vulvovaginitis Treatment,” Published Technical Disclosure No. 24-11857570_0010_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857570_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,570.

Summary of the Inventive Concept

The present inventive concept envisions next-generation ozonized olive oil formulations that overcome the limitations of traditional treatments for vulvovaginitis, providing enhanced efficacy, convenience, and patient comfort.

Background and Problem Solved

Vulvovaginitis remains a prevalent and recurring problem for women, with existing treatments often being inadequate or inconvenient. The original patent disclosed ozonized olive oil compositions with natural extracts, but these may not provide sustained relief or address the root causes of the infection. The new inventive concept addresses these limitations by introducing novel formulations and delivery systems that enhance the antimicrobial activity, bioavailability, and user experience of ozonized olive oil treatments.

Detailed Description of the Inventive Concept

The new inventive concept encompasses four key aspects: 1) encapsulation of ozonized olive oil in biodegradable nanoparticles for controlled release and targeted delivery; 2) pH-level maintenance in the vulvovaginal area to create an environment inhospitable to microbial growth; 3) synergistic blending of antimicrobial peptides and prebiotic fibers to enhance the antimicrobial activity of ozonized olive oil; and 4) development of devices such as vaginal rings or pessaries for sustained release and convenient administration. These advancements enable more effective, convenient, and patient-centric treatments for vulvovaginitis.

Novelty and Inventive Step

The new claims introduce significant innovations over the original patent, including the use of nanoparticles, pH-level control, and synergistic blending of antimicrobial peptides and prebiotic fibers. These advancements provide a paradigm shift in the treatment of vulvovaginitis, offering improved efficacy, convenience, and patient comfort.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different nanoparticle materials, varying the pH-level range, or incorporating additional natural extracts or antimicrobial agents. Variations may also involve different device designs or administration routes, such as creams, gels, or foams.

Potential Commercial Applications and Market

The advanced ozonized olive oil formulations and delivery systems have significant commercial potential in the women's health and gynecology markets, offering a novel solution for the treatment and prevention of vulvovaginitis. The target industries include pharmaceutical companies, medical device manufacturers, and healthcare providers.

Field of Art

Pharmaceutical and medical compositions for gynecological treatments, specifically focusing on topical antimicrobial formulations for vulvovaginitis management

Person of Ordinary Skill (PHOSITA) Profile

A pharmaceutical formulation specialist with expertise in natural product chemistry, drug delivery systems, and microbial infection treatments, holding at least a master's degree in pharmaceutical sciences or related field

Obviousness Rationale

A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core technology, utilizing standard pharmaceutical engineering techniques to enhance the delivery and efficacy of ozonized olive oil compositions for vulvovaginitis treatment. The proposed modifications involve well-known strategies in drug delivery and formulation optimization that would be immediately apparent to a skilled practitioner in the field. These variations demonstrate incremental improvements that leverage existing knowledge about antimicrobial compositions and targeted drug delivery mechanisms.

Obvious Combinations & Variations

Source Patent Element
Ozonized olive oil composition with natural extracts from Calendula officinalis and Melaleuca spp.
PTD Variation
Encapsulation of ozonized olive oil in biodegradable nanoparticles for controlled release
Obviousness Reasoning
Nanoparticle encapsulation is a standard pharmaceutical technique for improving drug delivery, and a PHOSITA would find it obvious to apply this known method to enhance the existing ozonized olive oil composition's efficacy and targeted delivery
Source Patent Element
Topical treatment composition for vulvovaginitis
PTD Variation
pH-level maintenance to create an environment inhospitable to microbial growth
Obviousness Reasoning
Controlling local pH to inhibit microbial growth is a well-established strategy in antimicrobial treatment, and a PHOSITA would recognize this as a predictable optimization of the existing treatment approach
Source Patent Element
Natural extract-based composition with antimicrobial properties
PTD Variation
Synergistic blending of antimicrobial peptides and prebiotic fibers
Obviousness Reasoning
Combining multiple antimicrobial agents to enhance efficacy is a standard pharmaceutical approach, and a PHOSITA would find it obvious to augment the existing natural composition with additional antimicrobial components
Source Patent Element
Topical ointment, cream, gel, or foam formulation
PTD Variation
Vaginal ring or pessary device for sustained release
Obviousness Reasoning
Alternative drug delivery devices are well-known in pharmaceutical engineering, and a PHOSITA would recognize the vaginal ring as a predictable modification of existing topical treatment methods
Source Patent Element
Ozonized olive oil composition with natural extracts
PTD Variation
Color-changing formulation to indicate microbial presence
Obviousness Reasoning
Diagnostic indicators are common in medical compositions, and a PHOSITA would find it obvious to incorporate a visual detection mechanism into an existing antimicrobial treatment
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857570, the variations disclosed in the Published Technical Disclosure would be obvious to a Person Having Ordinary Skill In The Art, as they represent predictable extensions of existing pharmaceutical formulation techniques applied to the treatment of vulvovaginitis. The proposed modifications utilize standard strategies in drug delivery, composition optimization, and antimicrobial treatment that would be immediately apparent to a skilled practitioner, thereby rendering any claims to these variations unpatentable under 35 U.S.C. Section 103.

Original Patent Information

Patent NumberUS 11,857,570
TitleNatural composition for use in gynecology
Assignee(s)ORGANICARE LLC