Anti-MICA Antigen Binding Fragments for Environmental and Health Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages the core technology of anti-MICA antigen binding fragments to develop novel solutions for environmental monitoring, health diagnostics, and food safety.
Background and Problem Solved
The original patent disclosed anti-MICA antigen binding fragments for immunotherapy applications. However, the limitations of the original patent lie in its narrow focus on cancer treatment. The new inventive concept addresses the need for innovative solutions in environmental monitoring, health diagnostics, and food safety by applying the core technology to these entirely new fields.
Detailed Description of the Inventive Concept
The new inventive concept comprises systems and methods utilizing anti-MICA antigen binding fragments for detecting and quantifying pollutants in air, waterborne pathogens, biomarkers for neurological disorders, heavy metals in soil, and contaminants in food products. These fragments can be engineered to bind specifically to target molecules, facilitating their detection and removal. The inventive concept's components include the anti-MICA antigen binding fragments, detection systems, and methods for sample preparation and analysis.
Novelty and Inventive Step
The new claims introduce novel applications and use cases for anti-MICA antigen binding fragments, which were not originally considered in the patent. The inventive step lies in the unexpected use of these fragments in environmental monitoring, health diagnostics, and food safety, demonstrating a non-obvious extension of the original technology.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different antigen binding fragments, detection systems, or sample preparation methods. Variations could also involve the integration of machine learning algorithms for data analysis or the development of portable detection devices.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the environmental monitoring, health diagnostics, and food safety industries. The market for these applications is substantial, with growing demands for innovative solutions to address pressing environmental and health concerns.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Biotechnology and molecular biology, specifically focused on antigen binding fragments, chimeric antigen receptors (CARs), and diagnostic/detection technologies involving protein engineering
Person of Ordinary Skill (PHOSITA) Profile
A skilled practitioner with advanced degrees in molecular biology or biotechnology, experienced in protein engineering, antibody fragment design, and diagnostic technology development, familiar with techniques for adapting molecular binding technologies to various detection and monitoring applications
Obviousness Rationale
A person having ordinary skill in the art would recognize that the anti-MICA antigen binding fragments disclosed in the source patent possess inherent versatility for detection and binding applications across multiple domains. The specific molecular characteristics of these fragments naturally lend themselves to adaptation in environmental monitoring, diagnostic, and detection technologies. The core binding mechanism of the anti-MICA fragments can be readily translated into diverse detection systems with predictable and expected results.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,571 |
|---|---|
| Title | Anti-mica antigen binding fragments, fusion molecules, cells which express and methods of using |
| Assignee(s) | The Trustees of Dartmouth College |