Anti-MICA Antigen Binding Fragments for Environmental and Health Applications

Publication ID: 24-11857571_0007_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Anti-MICA Antigen Binding Fragments for Environmental and Health Applications,” Published Technical Disclosure No. 24-11857571_0007_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857571_0007_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,571.

Summary of the Inventive Concept

This inventive concept leverages the core technology of anti-MICA antigen binding fragments to develop novel solutions for environmental monitoring, health diagnostics, and food safety.

Background and Problem Solved

The original patent disclosed anti-MICA antigen binding fragments for immunotherapy applications. However, the limitations of the original patent lie in its narrow focus on cancer treatment. The new inventive concept addresses the need for innovative solutions in environmental monitoring, health diagnostics, and food safety by applying the core technology to these entirely new fields.

Detailed Description of the Inventive Concept

The new inventive concept comprises systems and methods utilizing anti-MICA antigen binding fragments for detecting and quantifying pollutants in air, waterborne pathogens, biomarkers for neurological disorders, heavy metals in soil, and contaminants in food products. These fragments can be engineered to bind specifically to target molecules, facilitating their detection and removal. The inventive concept's components include the anti-MICA antigen binding fragments, detection systems, and methods for sample preparation and analysis.

Novelty and Inventive Step

The new claims introduce novel applications and use cases for anti-MICA antigen binding fragments, which were not originally considered in the patent. The inventive step lies in the unexpected use of these fragments in environmental monitoring, health diagnostics, and food safety, demonstrating a non-obvious extension of the original technology.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different antigen binding fragments, detection systems, or sample preparation methods. Variations could also involve the integration of machine learning algorithms for data analysis or the development of portable detection devices.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the environmental monitoring, health diagnostics, and food safety industries. The market for these applications is substantial, with growing demands for innovative solutions to address pressing environmental and health concerns.

Original Patent Information

Patent NumberUS 11,857,571
TitleAnti-mica antigen binding fragments, fusion molecules, cells which express and methods of using
Assignee(s)The Trustees of Dartmouth College