Synergistic CAR-T Cell Therapy System

Publication ID: 24-11857572_0003_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “Synergistic CAR-T Cell Therapy System,” Published Technical Disclosure No. 24-11857572_0003_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857572_0003_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,572.

Summary of the Inventive Concept

A novel system integrating CAR-T cell therapy with AI, IoT, blockchain, and nanomaterials to enhance T cell potency, optimize treatment protocols, and ensure secure patient data management.

Background and Problem Solved

The original patent discloses a method for preparing CAR-T cells with TCM as the main active component. However, the existing method lacks real-time monitoring, personalized treatment, and secure data management. The new inventive concept addresses these limitations by incorporating cutting-edge technologies to create a more powerful and efficient CAR-T cell therapy system.

Detailed Description of the Inventive Concept

The Synergistic CAR-T Cell Therapy System consists of a blockchain-based decentralized storage unit for storing T cell subset data, an AI-powered processing module for analyzing and optimizing T cell differentiation protocols, a wearable IoT device for real-time monitoring of T cell activity, and a cloud-based data analytics platform for tracking patient response and optimizing treatment protocols. Additionally, the system integrates a genetic testing module for identifying patient-specific genetic markers, a nanomaterial-based delivery system for targeted delivery of T cell stimulants, and an AI-powered optimization module for identifying optimal stimulant dosages and delivery protocols.

Novelty and Inventive Step

The new claims introduce the synergistic integration of AI, IoT, blockchain, and nanomaterials with CAR-T cell therapy, providing a novel and non-obvious solution for enhancing T cell potency, optimizing treatment protocols, and ensuring secure patient data management.

Alternative Embodiments and Variations

Alternative embodiments may include the use of different AI algorithms, IoT devices, or blockchain platforms. Variations may also involve the integration of additional technologies, such as CRISPR gene editing or synthetic biology, to further enhance the CAR-T cell therapy system.

Potential Commercial Applications and Market

The Synergistic CAR-T Cell Therapy System has significant commercial potential in the cancer treatment market, with potential applications in personalized medicine, precision oncology, and regenerative medicine.

Original Patent Information

Patent NumberUS 11,857,572
TitleMethod for preparing CAR-T cell with TCM as main active component and use thereof
Assignee(s)Xuanwu Hospital Capital Medical University