Synergistic CAR-T Cell Therapy System
Legal Citation
Summary of the Inventive Concept
A novel system integrating CAR-T cell therapy with AI, IoT, blockchain, and nanomaterials to enhance T cell potency, optimize treatment protocols, and ensure secure patient data management.
Background and Problem Solved
The original patent discloses a method for preparing CAR-T cells with TCM as the main active component. However, the existing method lacks real-time monitoring, personalized treatment, and secure data management. The new inventive concept addresses these limitations by incorporating cutting-edge technologies to create a more powerful and efficient CAR-T cell therapy system.
Detailed Description of the Inventive Concept
The Synergistic CAR-T Cell Therapy System consists of a blockchain-based decentralized storage unit for storing T cell subset data, an AI-powered processing module for analyzing and optimizing T cell differentiation protocols, a wearable IoT device for real-time monitoring of T cell activity, and a cloud-based data analytics platform for tracking patient response and optimizing treatment protocols. Additionally, the system integrates a genetic testing module for identifying patient-specific genetic markers, a nanomaterial-based delivery system for targeted delivery of T cell stimulants, and an AI-powered optimization module for identifying optimal stimulant dosages and delivery protocols.
Novelty and Inventive Step
The new claims introduce the synergistic integration of AI, IoT, blockchain, and nanomaterials with CAR-T cell therapy, providing a novel and non-obvious solution for enhancing T cell potency, optimizing treatment protocols, and ensuring secure patient data management.
Alternative Embodiments and Variations
Alternative embodiments may include the use of different AI algorithms, IoT devices, or blockchain platforms. Variations may also involve the integration of additional technologies, such as CRISPR gene editing or synthetic biology, to further enhance the CAR-T cell therapy system.
Potential Commercial Applications and Market
The Synergistic CAR-T Cell Therapy System has significant commercial potential in the cancer treatment market, with potential applications in personalized medicine, precision oncology, and regenerative medicine.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Immunotherapy, cellular engineering, specifically CAR-T cell development and optimization with focus on central memory T cell (Tcm) subset manipulation
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or immunologist with advanced degree, expertise in cellular therapy, familiarity with AI/machine learning applications in biotechnology, understanding of computational biology techniques
Obviousness Rationale
A PHOSITA would recognize that integrating computational technologies with CAR-T cell development represents a natural progression in personalized medicine. The source patent's foundational work on Tcm cell manipulation provides a clear technological framework that can be extended through emerging digital technologies. The proposed variations represent predictable applications of known computational techniques to an established cellular engineering methodology.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,572 |
|---|---|
| Title | Method for preparing CAR-T cell with TCM as main active component and use thereof |
| Assignee(s) | Xuanwu Hospital Capital Medical University |