CAR-T Cell Therapy for Diverse Disease Treatment

The inventive concept leverages the core technology of CAR-T cells with TCM as the main active component to treat various diseases beyond the original application, including respiratory, cardiovascular, neurodegenerative, inflammatory, and autoimmune diseases.

The original patent disclosed a method for preparing CAR-T cells with TCM as the main active component. However, the patent's scope was limited to a specific application. This inventive concept addresses the limitation by applying the core technology to diverse disease areas, providing a novel solution for unmet medical needs.

The inventive concept involves administering CAR-T cells with TCM as the main active component to patients in need of treatment for various diseases. The TCM is targeted to specific antigens associated with the respective diseases. This approach enables the CAR-T cells to selectively target and eliminate disease-causing cells, offering a promising therapeutic strategy. The system and composition embodiments encompass various administration routes, dosing regimens, and antigen targets, ensuring flexibility and adaptability across different disease indications.

The new claims introduce a significant inventive step by expanding the application of CAR-T cells with TCM beyond the original scope, demonstrating a non-obvious connection between the core technology and the newly targeted disease areas.

Alternative embodiments may involve modifying the CAR-T cell composition, such as using different antigen targets or incorporating additional therapeutic molecules. Variations may include combining the CAR-T cell therapy with other treatment modalities, like chemotherapy or gene therapy, to enhance therapeutic efficacy.

The inventive concept has significant commercial potential in the pharmaceutical and biotechnology industries, with a target market encompassing various disease areas, including respiratory, cardiovascular, neurodegenerative, inflammatory, and autoimmune diseases. The market size is substantial, with an estimated value in the billions of dollars.