CAR-T Cell Preparation Systems for Niche Environments
Legal Citation
Summary of the Inventive Concept
This inventive concept discloses specialized systems and methods for preparing CAR-T cells with TCM as the main active component, tailored for specific, high-demand niches such as disaster relief, high-security environments, and extreme weather conditions.
Background and Problem Solved
The original patent disclosed a method for preparing CAR-T cells with TCM as the main active component. However, these methods were not adapted for use in specialized environments, limiting their applicability. This inventive concept addresses the need for CAR-T cell preparation systems that can operate effectively in remote, high-security, or extreme weather conditions.
Detailed Description of the Inventive Concept
The inventive concept encompasses a range of systems and methods for preparing CAR-T cells with TCM as the main active component. Specifically, it includes a portable and compact device for use in remote or disaster relief areas, designed to store and preserve TCM cells at controlled temperatures and humidity levels. It also includes methods for preparing CAR-T cells with tamper-evident mechanisms, additional markers for tracking and identification in high-security environments, and specialized containers for transportation and storage in extreme weather conditions. Furthermore, the inventive concept comprises modular and scalable devices for use in temporary or mobile medical facilities, with interchangeable components for adapting to different operational environments.
Novelty and Inventive Step
The inventive concept's novelty lies in its adaptation of CAR-T cell preparation systems for specific, high-demand niches. The inventive step resides in the combination of features such as portability, tamper-evidence, and environmental resistance, which enable the systems and methods to operate effectively in challenging environments.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include the use of different materials or designs for the portable device, alternative tamper-evident mechanisms, or variations in the specialized container's insulation and temperature control systems.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the fields of disaster relief, high-security environments, and extreme weather conditions. Target industries include emergency medical services, government agencies, and specialized medical facilities.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Immunotherapy, specifically CAR-T cell engineering and preparation techniques, with expertise in cell manipulation, immunological marker identification, and biomedical device design
Person of Ordinary Skill (PHOSITA) Profile
A biomedical engineer or immunologist with advanced degree, familiar with CAR-T cell technologies, cell preservation techniques, and medical device engineering, capable of understanding complex cellular modification strategies
Obviousness Rationale
A PHOSITA would recognize that the PTD's variations represent predictable extensions of the source patent's core CAR-T cell technology, applying standard engineering principles to adapt the cellular preparation process for specialized environments. The disclosed modifications represent logical adaptations of existing CAR-T cell preparation methods to address practical deployment challenges. These variations demonstrate routine problem-solving within the field of cellular immunotherapy engineering.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,572 |
|---|---|
| Title | Method for preparing CAR-T cell with TCM as main active component and use thereof |
| Assignee(s) | Xuanwu Hospital Capital Medical University |