Cryopreserved Cell Restimulation for Enhanced Metabolic Performance
Legal Citation
Summary of the Inventive Concept
A novel approach to restimulate cryopreserved immune cells, microorganisms, and plant cells to enhance metabolic performance, applicable to various industries including sports, medicine, agriculture, and bioremediation.
Background and Problem Solved
The original patent focused on restimulating cryopreserved tumor infiltrating lymphocytes for cancer treatment. However, the limitations of this approach lie in its specificity to cancer therapy. The new inventive concept addresses this limitation by applying the core technology to entirely different industries, leveraging the potential of cryopreserved cell restimulation to enhance metabolic performance.
Detailed Description of the Inventive Concept
The new inventive concept involves restimulating cryopreserved cells to enhance specific metabolic pathways, depending on the target application. For instance, in athletic performance, cryopreserved immune cells are restimulated to enhance anaerobic metabolism, increasing endurance and reducing fatigue. In neurodegenerative diseases, cryopreserved immune cells are restimulated to promote mitochondrial metabolism, reducing oxidative stress and inflammation. Similarly, in agriculture, cryopreserved plant immune cells are restimulated to enhance glycolytic metabolism, increasing resistance to pathogens and environmental stressors.
Novelty and Inventive Step
The new claims introduce a paradigm shift in the application of cryopreserved cell restimulation, moving beyond cancer treatment to address unmet needs in diverse industries. The inventive step lies in recognizing the potential of this technology to enhance metabolic performance and developing specific methods for each target application.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include restimulating cryopreserved cells for enhanced lipid metabolism in cosmetic applications, or for improved ATP production in bioenergy generation. Variations of the method could involve using different types of cryopreserved cells, such as stem cells or dendritic cells, or combining restimulation with other therapies, like gene editing or small molecule inhibitors.
Potential Commercial Applications and Market
The inventive concept has far-reaching commercial potential, with applications in sports medicine, pharmaceuticals, agriculture, bioremediation, and cosmetics. The target market includes athletes, patients with neurodegenerative diseases, farmers, bioremediation companies, and cosmetic manufacturers, among others.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Cellular immunotherapy, specifically tumor infiltrating lymphocyte (TIL) manipulation, cell cryopreservation, and metabolic restimulation techniques in oncological and translational research
Person of Ordinary Skill (PHOSITA) Profile
A PhD-level researcher with expertise in immunology, cell biology, and cancer therapeutics, familiar with cell expansion, cryopreservation protocols, and metabolic engineering techniques
Obviousness Rationale
The PTD extends the source patent's core methodology of cryopreserved TIL restimulation by generalizing the technique across multiple cellular systems and metabolic contexts. A PHOSITA would recognize that the fundamental principles of cell revival, metabolic enhancement, and preservation demonstrated in the cancer TIL context are directly transferable to other cellular systems with predictable and reproducible outcomes.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,573 |
|---|---|
| Title | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| Assignee(s) | Iovance Biotherapeutics, Inc. |