Intelligent Restimulation of Cryopreserved Tumor Infiltrating Lymphocytes for Enhanced Adoptive Cell Therapy

This invention integrates AI, IoT, and blockchain technologies with the patented restimulation of cryopreserved tumor infiltrating lymphocytes (TILs) to create a more powerful system for adoptive cell therapy, enabling personalized cancer treatment with improved efficacy and reduced costs.

The original patent disclosed a method for restimulating cryopreserved TILs for adoptive cell therapy, but it had limitations in terms of scalability, data tracking, and treatment optimization. This new inventive concept addresses these limitations by incorporating advanced technologies to create a more efficient, secure, and effective system.

The system comprises a blockchain-based data storage module for secure tracking of patient-specific TIL expansion, a machine learning-based predictive analytics module for optimizing restimulation protocols, and an IoT-enabled cell expansion monitoring system for real-time tracking. The system also integrates an AI-driven biomarker analysis module for identifying predictive biomarkers of treatment response and a decentralized blockchain-based platform for secure sharing of patient data. This integrated system enables personalized cancer treatment with improved efficacy, reduced costs, and enhanced patient outcomes.

The new claims introduce the novel combination of AI, IoT, and blockchain technologies with the patented restimulation of cryopreserved TILs, providing a non-obvious solution to the limitations of the original patent. The inventive step lies in the integration of these advanced technologies to create a more powerful system for adoptive cell therapy.

Alternative embodiments of the inventive concept could include the use of different AI algorithms, IoT devices, or blockchain platforms. Variations could also include the integration of additional technologies, such as natural language processing or computer vision, to further enhance the system's capabilities.

The inventive concept has significant commercial potential in the field of adoptive cell therapy, with potential applications in cancer treatment centers, hospitals, and pharmaceutical companies. The market for adoptive cell therapy is growing rapidly, and this invention could capture a significant share of the market with its enhanced efficacy, reduced costs, and improved patient outcomes.