Metabolic Shift-Enabled Industrial Applications
Legal Citation
Summary of the Inventive Concept
This inventive concept leverages the core technology of restimulating cryopreserved tumor infiltrating lymphocytes to develop novel solutions for various industries, including solar panel manufacturing, electric vehicle batteries, food preservation, skincare, and fuel cells.
Background and Problem Solved
The original patent focused on the treatment of bulky, refractory cancers using adoptive transfer of tumor infiltrating lymphocytes (TILs). However, the metabolic shift principles and restimulation protocol disclosed in the patent have broader implications. This inventive concept addresses the limitations of existing solutions in various industries by applying the core technology to enhance performance, efficiency, and shelf life.
Detailed Description of the Inventive Concept
The newly generated claims describe methods and systems that adapt the restimulation protocol to improve the efficiency of solar panel manufacturing, monitor and optimize electric vehicle battery health, increase the shelf life of perishable food products, develop personalized skincare products, and enhance fuel cell performance. These applications capitalize on the metabolic shift principles to optimize the performance of photovoltaic cells, microorganisms, skin cells, and fuel cells. The inventive concept involves the restimulation of cryopreserved cells or microorganisms to enhance their metabolic activity, leading to improved outcomes in the respective industries.
Novelty and Inventive Step
The novelty of this inventive concept lies in the unexpected application of the restimulation protocol to industries unrelated to cancer treatment. The inventive step involves the recognition of the broader potential of the metabolic shift principles and the adaptation of the restimulation protocol to address specific problems in various industries.
Alternative Embodiments and Variations
Alternative embodiments may include variations in the restimulation protocol, such as adjustments to the cryopreservation process, changes in the composition of the dissociated tumor materials, or modifications to the metabolic shift principles. Additionally, the inventive concept could be applied to other industries, such as agriculture, biotechnology, or environmental remediation.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in various industries, including renewable energy, electric vehicles, food technology, cosmetics, and energy storage. The market for these applications is substantial, with potential customers ranging from manufacturers and suppliers to consumers and end-users.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Cellular biotechnology, specifically cell expansion, cryopreservation, and metabolic engineering techniques with expertise in cell culture, preservation protocols, and cross-industry cellular optimization strategies
Person of Ordinary Skill (PHOSITA) Profile
A PhD-level biotechnologist with advanced training in cell biology, experience in cell expansion techniques, familiarity with cryopreservation methods, and knowledge of metabolic engineering principles across multiple scientific domains
Obviousness Rationale
The published technical disclosure represents a predictable extension of the source patent's core methodology of cellular restimulation and metabolic shift principles. A skilled practitioner would readily recognize that the fundamental cellular manipulation techniques disclosed in the tumor infiltrating lymphocyte patent could be analogously applied to other cell types and industrial contexts. The metabolic shift principles are sufficiently generalizable that a PHOSITA would understand their potential for broad technological translation.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,573 |
|---|---|
| Title | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| Assignee(s) | Iovance Biotherapeutics, Inc. |