Adaptive Restimulation of Cryopreserved Tumor Infiltrating Lymphocytes for Specialized Environments
Legal Citation
Summary of the Inventive Concept
This inventive concept adapts the restimulation of cryopreserved tumor infiltrating lymphocytes for specific, narrow market or unique operational environments, addressing high-security needs, disaster relief, extreme weather conditions, and resource-constrained areas.
Background and Problem Solved
The original patent disclosed a method for restimulating cryopreserved tumor infiltrating lymphocytes, but it did not address the limitations and challenges of implementing this technology in specialized environments. This inventive concept solves the problem of adapting the restimulation process for unique operational environments, ensuring the effective treatment of bulky, refractory cancers in a variety of settings.
Detailed Description of the Inventive Concept
The inventive concept comprises four specialized variations of the restimulation method: 1) a secure, isolated environment for high-security needs; 2) a portable cryopreservation unit and restimulation protocol module for disaster relief; 3) a thermally insulated container and temperature-resistant bioreactor for extreme weather conditions; and 4) a low-power, portable thawing device and simplified cocktail of cytokines and growth factors for remote, resource-constrained areas. These variations ensure the effective restimulation of cryopreserved tumor infiltrating lymphocytes in diverse environments.
Novelty and Inventive Step
The new claims introduce novel and non-obvious adaptations of the restimulation method for specialized environments, including the use of secure, isolated environments, portable cryopreservation units, thermally insulated containers, and low-power, portable thawing devices. These adaptations provide a significant improvement over the original patent by enabling the effective treatment of bulky, refractory cancers in a variety of settings.
Alternative Embodiments and Variations
Other embodiments of the inventive concept could include adaptations for use in high-altitude or high-radiation environments, or for treating specific types of cancer. Additionally, the restimulation method could be integrated with other immunotherapies or cancer treatments to enhance its effectiveness.
Potential Commercial Applications and Market
The inventive concept has significant commercial potential in the fields of immunotherapy and cancer treatment, particularly in high-security, disaster relief, and resource-constrained settings. The market for this technology is expected to grow as the need for adaptable and effective cancer treatments increases.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Immunotherapy and cell processing, specifically tumor infiltrating lymphocyte (TIL) manipulation and cryopreservation techniques, requiring advanced knowledge of cell biology, immunology, and biomedical engineering
Person of Ordinary Skill (PHOSITA) Profile
A researcher or biomedical engineer with advanced degree (PhD/MD), expertise in cell culture techniques, immunotherapy protocols, cryopreservation methods, and experience with cancer treatment cell processing
Obviousness Rationale
A PHOSITA would recognize that the disclosed variations represent predictable adaptations of the source patent's core TIL restimulation method, applying standard engineering problem-solving techniques to address environmental and operational constraints. The fundamental scientific principles of TIL expansion and cryopreservation remain consistent across the variations. The modifications represent routine engineering design choices that would be apparent to a skilled practitioner seeking to implement the core technology in diverse operational contexts.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,573 |
|---|---|
| Title | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| Assignee(s) | Iovance Biotherapeutics, Inc. |