Personalized Skin Therapy and Neurogenic Inflammation Management System

Publication ID: 24-11857578_0010_PTD
Published: October 28, 2025
Category:Future Evolutions & Paradigm Shifts

Legal Citation

pr1or.art Inc., “Personalized Skin Therapy and Neurogenic Inflammation Management System,” Published Technical Disclosure No. 24-11857578_0010_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857578_0010_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,578.

Summary of the Inventive Concept

A comprehensive system for personalized skin therapy and neurogenic inflammation management, leveraging machine learning, metagenomics, and wearable devices to provide tailored treatments and real-time monitoring.

Background and Problem Solved

The original patent disclosed a novel bacterial extract for treating sensitive skin, but it had limitations in terms of personalized treatment and real-time monitoring. The new inventive concept addresses these limitations by introducing a system that integrates machine learning, metagenomics, and wearable devices to provide a more effective and personalized approach to skin therapy and neurogenic inflammation management.

Detailed Description of the Inventive Concept

The system comprises a bacterial extract from a non-pathogenic Gram-negative bacterium belonging to the class Betaproteobacteria, subfamily Neisseriaceae, and a neural network-based algorithm for predicting individual skin responses to said extract. The system also includes a wearable device for real-time monitoring of skin neurogenic inflammation, which transmits data to a cloud-based server for analysis and recommendation of a personalized treatment regimen. Furthermore, the system incorporates a composition of matter comprising a novel bacterial strain engineered to produce a specific neurogenic inflammation-modulating compound. The cloud-based platform for crowdsourced skin health data enables users to upload their skin health metrics and receive personalized recommendations for treating cutaneous neurogenic inflammation based on machine learning-driven analysis of aggregated data.

Novelty and Inventive Step

The new claims introduce a paradigm shift in skin therapy and neurogenic inflammation management by integrating machine learning, metagenomics, and wearable devices. The inventive concept's novelty lies in the combination of these technologies to provide a personalized and real-time approach to skin health management, which is not obvious from the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of different machine learning algorithms, wearable devices with varying sensor configurations, or the integration of additional data sources such as environmental or lifestyle factors. Variations of the system could also be developed for specific skin conditions or demographics.

Potential Commercial Applications and Market

The inventive concept has significant commercial potential in the skincare and pharmaceutical industries, with a target market of individuals seeking personalized and effective solutions for skin health management. The system's ability to provide real-time monitoring and tailored treatments could revolutionize the way skin conditions are managed, offering a competitive advantage in the market.

Field of Art

Microbiological and dermatological biotechnology, with expertise in bacterial extract development, skin inflammation research, and computational biology

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in microbiology or biotechnology, familiar with bacterial genomics, machine learning techniques, and skin inflammation treatment methodologies

Obviousness Rationale

A PHOSITA would recognize that integrating machine learning, wearable sensor technology, and personalized medicine approaches with the existing bacterial extract technology represents a predictable and logical extension of the source patent's core innovations. The combination of computational analysis with bacterial extract treatment is a natural progression in personalized medical technologies. The technical elements disclosed in the PTD represent incremental improvements that would be obvious to a skilled practitioner seeking to enhance the utility and precision of the original bacterial extract invention.

Obvious Combinations & Variations

Source Patent Element
Bacterial extract from non-pathogenic Gram-negative bacterium with specific 16S rRNA sequence
PTD Variation
Neural network-based algorithm for predicting individual skin responses to bacterial extract
Obviousness Reasoning
Applying machine learning to biological data is a well-established technique, and developing predictive models for biological responses is a known approach in personalized medicine
Source Patent Element
Method for treating cutaneous neurogenic inflammation
PTD Variation
Wearable device for real-time monitoring of skin neurogenic inflammation with cloud-based analysis
Obviousness Reasoning
Integrating continuous monitoring technologies with existing treatment methodologies is a predictable technological progression in medical diagnostics
Source Patent Element
Bacterial strain LMB64 with specific genetic characteristics
PTD Variation
Engineered bacterial strain producing specific neurogenic inflammation-modulating compound
Obviousness Reasoning
Genetic engineering of bacterial strains to enhance therapeutic properties is a standard technique in biotechnology with expected and predictable outcomes
Source Patent Element
Bacterial extract composition for skin treatment
PTD Variation
Cloud-based platform for crowdsourced skin health data and personalized recommendations
Obviousness Reasoning
Leveraging aggregated user data for personalized medical insights is a known approach in digital health technologies
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857578 and the published technical disclosure, a person of ordinary skill in the art would find the claimed variations obvious, as they represent predictable combinations of known techniques in bacterial extract technology, machine learning, and personalized medical monitoring. The disclosed system extends the original invention through standard technological integration methods that would be apparent to a skilled practitioner in the field of dermatological biotechnology.

Original Patent Information

Patent NumberUS 11,857,578
TitleExtract and dermatological composition comprising same, for treating sensitive skin
Assignee(s)PIERRE FABRE DERMO-COSMETIQUE