Microbial FGF21-based Solutions for Environmental Sustainability

Publication ID: 24-11857579_0002_PTD
Published: October 28, 2025
Category:New Applications & Use Cases

Legal Citation

pr1or.art Inc., “Microbial FGF21-based Solutions for Environmental Sustainability,” Published Technical Disclosure No. 24-11857579_0002_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857579_0002_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,579.

Summary of the Inventive Concept

The present inventive concept leverages the core technology of the original patent to develop novel applications in environmental sustainability, utilizing Bifidobacterium breve M-16V to promote the secretion of FGF21, which enhances plant growth, degrades pollutants, improves biogas production, reduces greenhouse gas emissions, and optimizes water purification.

Background and Problem Solved

The original patent focused on modulating palatability and maintaining body temperature in humans. However, the technology's potential extends beyond human health. Environmental sustainability is a pressing global issue, with challenges including inefficient plant growth, soil contamination, inadequate biogas production, and ineffective water purification. The present inventive concept addresses these limitations by applying the core technology to novel applications in environmental sustainability.

Detailed Description of the Inventive Concept

The inventive concept involves utilizing Bifidobacterium breve M-16V to promote the secretion of FGF21, which is then applied to various environmental sustainability applications. In plant growth promotion, FGF21 enhances nutrient uptake and root development, leading to improved crop yields. For soil remediation, FGF21 stimulates microbial degradation of pollutants, restoring soil health. In biogas production, FGF21 optimizes fermentation conditions, increasing energy output. By reducing methane production in agricultural settings, FGF21 contributes to greenhouse gas emission reduction. Finally, FGF21 enhances the removal of contaminants from water, improving purification efficiency.

Novelty and Inventive Step

The novelty of the present inventive concept lies in the unexpected application of Bifidobacterium breve M-16V to promote FGF21 secretion in environmental sustainability contexts. The inventive step resides in the recognition of FGF21's potential to address pressing environmental challenges and the development of novel compositions and methods to harness this potential.

Alternative Embodiments and Variations

Alternative embodiments of the inventive concept could include the use of other Bifidobacterium strains or microbial species to promote FGF21 secretion. Variations may involve different application methods, such as soil injection or foliar spraying, or the development of FGF21-based bioproducts for environmental remediation.

Potential Commercial Applications and Market

The present inventive concept has significant commercial potential in the environmental sustainability sector, with target industries including agriculture, biotechnology, and water treatment. The market for microbial-based environmental solutions is rapidly growing, and the inventive concept's novel applications and benefits position it for strong market penetration and adoption.

Field of Art

Microbial biotechnology, specifically probiotics, microbial metabolic engineering, and environmental biotechnology with a focus on fibroblast growth factors and microbial interactions

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced degrees in microbiology, biotechnology, or environmental science, possessing expertise in microbial strain characterization, metabolic pathway analysis, and applied biotechnological applications

Obviousness Rationale

A person having ordinary skill in the art would recognize that the FGF21 secretion properties of Bifidobacterium breve M-16V inherently suggest broader applications beyond the original physiological context. The molecular mechanisms underlying FGF21 production and its signaling properties would naturally motivate exploration of environmental and industrial applications as disclosed in the published technical disclosure.

Obvious Combinations & Variations

Source Patent Element
Bifidobacterium breve M-16V with ability to modulate physiological processes through FGF21 secretion
PTD Variation
Applying FGF21 secretion mechanisms to environmental sustainability applications like plant growth and soil remediation
Obviousness Reasoning
Predictable extension of known microbial metabolic capabilities, representing a logical application of established biotechnological principles
Source Patent Element
Method of administering Bifidobacterium breve M-16V in food or pharmaceutical compositions
PTD Variation
Developing environmental application compositions using the same bacterial strain for soil, water, and agricultural interventions
Obviousness Reasoning
Known technique of repurposing microbial strains across different application domains, representing a standard approach in biotechnological research
Source Patent Element
Understanding of FGF21's role in metabolic signaling
PTD Variation
Leveraging FGF21's signaling properties to enhance biological processes in environmental contexts
Obviousness Reasoning
Finite set of predictable applications based on molecular signaling characteristics, representing an obvious technological progression
Source Patent Element
Bacterial strain with specific metabolic capabilities
PTD Variation
Expanding strain's utility to address environmental sustainability challenges
Obviousness Reasoning
Systematic exploration of microbial potential across different domains, representing a standard scientific methodology
Source Patent Element
Method of modulating physiological processes through bacterial administration
PTD Variation
Applying similar administration strategies to environmental and industrial biotechnology contexts
Obviousness Reasoning
Known technique of translating biological mechanisms across different technological domains, representing a predictable scientific approach
35 U.S.C. § 103 Summary: Based on the teachings of US Patent 11857579 and the published technical disclosure, a person having ordinary skill in the art would find the environmental applications of Bifidobacterium breve M-16V and its FGF21 secretion mechanisms to be obvious variations of the prior art, thereby rendering potential claims to such applications unpatentable under 35 U.S.C. ยง 103 due to the predictable extension of known microbial biotechnological principles.

Original Patent Information

Patent NumberUS 11,857,579
TitleComposition for promoting the secretion of FGF21
Assignee(s)Morinaga Milk Industry Co., Ltd.