FGF21 Secretion Enhancement System via Synergistic Combinations

Publication ID: 24-11857579_0008_PTD
Published: October 28, 2025
Category:Synergistic Combinations

Legal Citation

pr1or.art Inc., “FGF21 Secretion Enhancement System via Synergistic Combinations,” Published Technical Disclosure No. 24-11857579_0008_PTD, Published October 28, 2025, available at https://archive.pr1or.art/24-11857579_0008_PTD
This technical disclosure describes improvements that would be readily apparent to a Person Having Ordinary Skill In The Art (PHOSITA) when considered in combination with the foundational architecture disclosed in U.S. Patent No. 11,857,579.

Summary of the Inventive Concept

A novel system integrating a Bifidobacterium bacterium with distinct technologies such as AI, IoT, blockchain, and new materials to enhance FGF21 secretion, offering improved efficacy and personalized health management.

Background and Problem Solved

The original patent disclosed a composition for promoting FGF21 secretion, but it had limitations in terms of efficacy and customization. The new inventive concept addresses these limitations by combining the Bifidobacterium bacterium with advanced technologies to create a more powerful and personalized system.

Detailed Description of the Inventive Concept

The system comprises a Bifidobacterium bacterium, which promotes FGF21 secretion, integrated with various technologies. For instance, an AI-powered personalized nutrition planning module provides customized dietary plans based on the subject's genetic profile, enhancing the bacterium's efficacy. A blockchain-based health data management system tracks and analyzes the subject's health data to optimize the bacterium's administration and dosage. A novel, edible, graphene-based material enhances the bacterium's bioavailability and promotes its colonization in the gut. A wearable IoT device tracks the subject's physiological parameters, and the bacterium promotes FGF21 secretion in response to the tracked parameters. Machine learning algorithms analyze the subject's genetic profile, health data, and lifestyle factors to provide a personalized prediction of the bacterium's efficacy.

Novelty and Inventive Step

The new inventive concept introduces a synergistic combination of distinct technologies with the Bifidobacterium bacterium, creating a novel system that enhances FGF21 secretion and provides personalized health management. The integration of these technologies with the bacterium is non-obvious and represents a significant advancement over the original patent.

Alternative Embodiments and Variations

Alternative embodiments of the system could include integrating the Bifidobacterium bacterium with other AI-powered modules, such as personalized exercise planning or stress management. Variations could also include using different types of bacteria or combining the system with other health monitoring devices.

Potential Commercial Applications and Market

The FGF21 secretion enhancement system has significant commercial potential in the health and wellness industry, particularly in the areas of personalized nutrition, health monitoring, and disease prevention. Target markets could include health-conscious consumers, athletes, and individuals with chronic diseases.

Field of Art

Microbiome biotechnology, specifically probiotics and metabolic health interventions involving bacterial strains and their physiological interactions

Person of Ordinary Skill (PHOSITA) Profile

A researcher with advanced training in microbiology, biotechnology, or medical sciences, possessing expertise in probiotic strain characterization, metabolic pathway modulation, and interdisciplinary health technology integration

Obviousness Rationale

A person of ordinary skill would recognize that integrating advanced technologies with known probiotic mechanisms represents a predictable extension of existing microbiome research. The source patent's foundational work on Bifidobacterium breve M-16V provides a clear technological platform for exploring enhanced delivery and personalization strategies. The PTD's proposed technological integrations represent logical, incremental improvements that would be apparent to a skilled practitioner seeking to optimize probiotic interventions.

Obvious Combinations & Variations

Source Patent Element
Bifidobacterium breve M-16V bacterial strain for modulating physiological parameters
PTD Variation
AI-powered personalized nutrition planning module integrated with bacterial administration
Obviousness Reasoning
Combining computational analysis with probiotic interventions is a known technique in precision medicine, representing a predictable application of existing technological capabilities
Source Patent Element
Method of administering Bifidobacterium bacterium for metabolic modulation
PTD Variation
Blockchain-based health data tracking to optimize bacterial administration
Obviousness Reasoning
Systematic data management for biological interventions is a standard approach in biotechnology, representing an obvious design choice for improving treatment protocols
Source Patent Element
Composition involving Bifidobacterium bacterium for physiological modulation
PTD Variation
Graphene-based material enhancing bacterial bioavailability
Obviousness Reasoning
Material science techniques for improving biological delivery are well-established, representing a finite set of predictable engineering solutions
Source Patent Element
Method of promoting metabolic responses using bacterial strains
PTD Variation
IoT device tracking physiological parameters to guide bacterial intervention
Obviousness Reasoning
Real-time physiological monitoring integrated with biological interventions is a logical extension of existing precision health technologies
35 U.S.C. § 103 Summary: Pursuant to 35 U.S.C. ยง 103, the variations disclosed in this published technical disclosure would have been obvious to a person having ordinary skill in the art at the time of invention, with a reasonable expectation of success, based on the foundational teachings of US Patent 11857579 and the predictable integration of known technological approaches in microbiome biotechnology.

Original Patent Information

Patent NumberUS 11,857,579
TitleComposition for promoting the secretion of FGF21
Assignee(s)Morinaga Milk Industry Co., Ltd.