Adapted Lactobacillus Composition for Specialized Vaginal Health Applications
Legal Citation
Summary of the Inventive Concept
The present inventive concept relates to adapted Lactobacillus compositions for specialized vaginal health applications, providing targeted solutions for high-altitude, emergency response, extreme cold, resource-constrained, and high-humidity environments.
Background and Problem Solved
The original patent disclosed a Lactobacillus composition with antimicrobial effects on Gardnerella vaginalis and Candida albicans. However, this composition may not be suitable for specific, niche environments where vaginal infections are more prevalent or challenging to treat. The present inventive concept addresses this limitation by adapting the composition for these unique settings, ensuring effective prevention and treatment of vaginal infections in diverse operational environments.
Detailed Description of the Inventive Concept
The adapted Lactobacillus composition comprises a cell-free supernatant of Lactobacillus paracasei MG4272 strain, which is formulated to remain stable and effective in specific environments. For high-altitude environments, the composition is designed to withstand low oxygen levels. In emergency response situations, the composition is part of a kit that includes easy-to-administer formulations. For extreme cold environments, the composition is formulated to remain stable at temperatures below -20°C. In resource-constrained environments, the composition is designed for ease of administration and minimal logistical requirements. Finally, for high-humidity environments, the composition is formulated to remain stable in humid conditions. The composition's antifungal and antimicrobial activities against Gardnerella vaginalis and Candida albicans remain unaffected in these adapted formulations.
Novelty and Inventive Step
The novelty of the present inventive concept lies in the adaptation of the Lactobacillus composition for specific, niche environments, which requires a deep understanding of the interplay between the composition's stability, the environment's challenges, and the target pathogens. The inventive step involves the formulation of the composition to address these unique challenges, ensuring effective prevention and treatment of vaginal infections in diverse operational environments.
Alternative Embodiments and Variations
Alternative embodiments of the inventive concept could include adapting the composition for other specialized environments, such as high-radiation or high-temperature settings. Variations of the composition could also be developed for different vaginal health applications, such as prevention of sexually transmitted infections or treatment of vaginal dryness.
Potential Commercial Applications and Market
The adapted Lactobacillus composition has significant commercial potential in the feminine hygiene and healthcare industries, particularly in niche markets focused on specialized environments. The composition could be marketed as a targeted solution for women working or living in high-altitude, emergency response, extreme cold, resource-constrained, or high-humidity environments, providing a competitive advantage in these underserved markets.
Section 103 Obviousness Analysis (PHOSITA)
Field of Art
Microbiology, specifically probiotic compositions for vaginal health and microbiome management, requiring expertise in microbial strain characterization, environmental stability testing, and therapeutic formulation development
Person of Ordinary Skill (PHOSITA) Profile
A microbiologist or biotechnologist with advanced degree, experience in probiotic strain isolation, characterization of bacterial metabolites, and understanding of microbial adaptation to environmental conditions
Obviousness Rationale
A person having ordinary skill would recognize that adapting the Lactobacillus paracasei MG4272 strain's cell-free supernatant for specialized environments represents a predictable engineering variation based on known microbial stability principles. The source patent establishes the strain's fundamental antimicrobial properties, making environmental adaptation a logical extension of the original research. The PTD's variations demonstrate routine optimization techniques familiar to skilled practitioners in microbial formulation design.
Obvious Combinations & Variations
Original Patent Information
| Patent Number | US 11,857,580 |
|---|---|
| Title | Lactobacillus having antimicrobial effect on Gardnerella vaginalis and Candida albicans |
| Assignee(s) | Mediogen Co., Ltd. |